“…We utilize the X10 method for tenfold expansion of U2OS cells with concurrent DNA staining. A custom 3D-printed gel cutter and chambered slides minimize gel drift, facilitating analysis of the components of nuclear structures at nanoscale resolution by conventional microscopy or Airyscan confocal imaging. …”
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“…Then we describe the uptake of conjugated PFFs by U2OS cells plated on Permanox 8-well chamber slides. …”
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“…CCK-8 and cell apoptosis assay were performed to evaluate the function of MFNG in U2OS cells. RESULTS: Among the obtained genes, Manic Fringe (MFNG) had the closest relevance to prognosis and clinical traits, thus becoming the research object herein. …”
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“…Correlations were identified between IF aberrancies and mutations, including positive Ogata>2 and mutations in SRSF2 (p=0.035), CD15 and U2AF1 (0.032), CD56 and DNMT3A (p=0.042), and CD38 and TP53 (p=0.026). …”
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“…The impact of INHBA silencing on OS development was then explored by transfecting the OS cell lines U2OS and MG63 with INHBA-small interfering RNA (siRNA). …”
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“…DNA damage response activation was also shown in both p53-defective HeLa cells and p53-proficient U2OS cells by the detection of the phosphorylated form of H2AX after peptide treatment. …”
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“…Incremental AUC(120min) PG also significantly decreased, and β-cell function assessed by IGI(30min), AUC(120min) insulin, and the AUC(120min) SUIT index significantly increased (0.16 ± 0.05 vs. 0.28 ± 0.06, 2692 ± 333 µU·2h/mL vs. 3537 ± 361 µU·2h/mL, and 4261 ± 442 vs. 8290 ± 1147, respectively; all p < 0.05). …”
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“…These 11 patients required an average of 10 U of R, 11 U of P, 14 U of F and 10 U of C pretreatment compared to an average of 1 U, 2 U, 2 U and 0 U of R, P, F, and C respectively, post-treatment. …”
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“…In contrast, other multigene families (45S rDNA and U2 snRNA) have conserved distribution among individuals. …”
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“…Self-rated emotional (U = 2,730.0, z = −6.169) and hyperactivity (U = 3,445.0, z = −4.506) SDQ subscale as well as informant (U = 188.5, z = −3.916) and self-rated (U = 3,178.5, z = −5.083) total scores were significantly worse for patients compared to healthy participants (p < 0.001). …”
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“…However, an increase of apoptosis was seen in p53-positive U2OS and 143B after CXCR4 inhibitor incubation, while no changes were seen in treated SAOS-2 cells which also present a different labeling profile. …”
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“…Therefore, the aim of the present study was to evaluate the preclinical antitumor activity of dDAVP in osteosarcoma. Human MG-63 and U-2 OS osteosarcoma cell lines were used to assess in vitro and in vivo therapeutic effects of dDAVP. …”
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“…For this purpose, two human osteosarcoma cell lines (143B and U2OS) were introduced in this study and treated with PHA-665752. …”
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“…Acute high glucose activated STAT3, driving the subsequent expression of XRCC1 in U2OS and HEK293T cells through increased STAT3 occupancy at the XRCC1 promoter. …”
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“…METHODS: We examined the combined effect of PIP and DOX on U2OS and 143B osteosarcoma cells. CCK-8 assays, scratch assays, flow cytometry analysis, and western blotting were performed. …”
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“…Chapter 5 describes non-Abelian gauge theories from a classical, geometric point of view, in analogy to Maxwell theory as a prototype, and culminates in an application to the U(2) theory relevant for electroweak interactions. …”
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“…Finally, we will address the main background and the measurement feasibility with dimuons at forward rapidity for the future LHCb U2 set-up.…”
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“…According to branching formulae, which are obtained by composing representations and $\ast$-endomorphisms, it is shown that a KMS state of the CAR algebra is obtained through the above even-CAR endomorphisms from the Fock representation. A $U(2^p)$ action on ${\mathcal O}_{2^p}$ induces $\ast$-automorphisms of the CAR algebra, which are given by nonlinear transformations expressed in terms of polynomials in generators. …”
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“…According to branching formulae, which are obtained by composing representations and $\ast$-endomorphisms, it is shown that a KMS state of the CAR algebra is obtained through the above even-CAR endomorphisms from the Fock representation. A $U(2^p)$ action on ${\mathcal O}_{2^p}$ induces $\ast$-automorphisms of the CAR algebra, which are given by nonlinear transformations expressed in terms of polynomials in generators. …”
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“…All the new compounds exhibited moderate to good antiproliferative activity against the human osteosarcoma U2OS cell line. NMR and docking experiments revealed that the recently synthesized compounds interact with the Pu22 G-quadruplex in the c-MYC promoter region, establishing a 2:1 complex, with each molecule positioned over the tetrads at the 3′- and 5′-ends.…”
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