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1281por Cao, Zhen, Kuhne, Wendy W., Steeb, Jennifer, Merkley, Mark A., Zhou, Yunfeng, Janata, Jiri, Dynan, William S.“…We demonstrate the use of this system for tracking assembly of individual repair foci in real time in live U2OS human osteosarcoma cells. Results indicate that there is a subset of foci that appear and disappear rapidly, before a plateau level is reached ∼30 min post-exposure. …”
Publicado 2010
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1282“…In the crystal structure of the title compound, [U(2)(NO(3))(2)O(4)(O(2))(C(4)H(7)NO)(4)], two UO(2) (2+) ions are connected by a μ-η(2):η(2)-O(2) unit. …”
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1283“…To elucidate these properties, we visualized the actomyosin dynamics and organization in U2OS cells over a broad range of forces. At low forces, contractile lamellar networks predominate and force generation is strongly correlated to actomyosin retrograde flow dynamics with nominal change in organization. …”
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1284por Paronetto, Maria Paola, Messina, Valeria, Barchi, Marco, Geremia, Raffaele, Richard, Stéphane, Sette, Claudio“…RNA and chromatin crosslink immunoprecipitation experiments showed that Sam68 binds in vivo to sequences surrounding the intron 7/exon 8 boundary, thereby affecting the recruitment of the phosphorylated RNAPII and of the general splicing factor U2AF65. These results suggest that Sam68 regulates alternative splicing at transcriptionally active sites in differentiating germ cells and provide new insights into the regulation of Sam68 expression during spermatogenesis.…”
Publicado 2011
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1285“…Knock-down of PDGFR-β in U2OS osteosarcoma cells also inhibited cell migration which, could not be further inhibited in the presence of E7080. …”
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1286“…RESULTS: We inactivated Aurora-A in human U2OS osteosarcoma cells either by RNA-interference-mediated silencing or treating cultures with the specific inhibitor MLN8237. …”
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1287por Muñoz, Ivan M., MacArtney, Thomas, Sanchez-Pulido, Luis, Ponting, Chris P., Rocha, Sonia, Rouse, John“…FAM60A expression peaks during G(1) and S phases of the cell cycle in U2OS cells, in a manner similar to the G(1) regulator cyclin D1, which is a known target of SIN3-HDAC. …”
Publicado 2012
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1288por Kammel, Christine, Thomaier, Maren, Sørensen, Brian B., Schubert, Thomas, Längst, Gernot, Grasser, Marion, Grasser, Klaus D.“…The DEAD-box protein UAP56 (U2AF65-associcated protein) is an RNA helicase that in yeast and metazoa is critically involved in mRNA splicing and export. …”
Publicado 2013
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1289por Li, Xu-Wen, Herrmann, Jennifer, Zang, Yi, Grellier, Philippe, Prado, Soizic, Müller, Rolf, Nay, Bastien“…The loss of mitochondrial membrane potential induced by aurachins in human U-2 OS osteosarcoma cells was studied, showing the best activity for aurachin D and a naphthalene analogue, yet without totally explaining the observed cytotoxic activity of the compounds. …”
Publicado 2013
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1290por Tessereau, Chloé, Buisson, Monique, Monnet, Nastasia, Imbert, Marine, Barjhoux, Laure, Schluth-Bolard, Caroline, Sanlaville, Damien, Conseiller, Emmanuel, Ceppi, Maurizio, Sinilnikova, Olga M., Mazoyer, Sylvie“…Although the breast cancer susceptibility gene BRCA1 is one of the most extensively characterized genetic loci, much less is known about its upstream variable number tandem repeat element, the RNU2 locus. RNU2 encodes the U2 small nuclear RNA, an essential splicing element, but this locus is missing from the human genome assembly due to the inherent difficulty in the assembly of repetitive sequences. …”
Publicado 2013
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1291por Rahman, Mohammad Alinoor, Masuda, Akio, Ohe, Kenji, Ito, Mikako, Hutchinson, David O., Mayeda, Akila, Engel, Andrew G., Ohno, Kinji“…Interaction of hnRNP L with PTB inhibits association of U2AF(65) and U1 snRNP with the upstream and downstream of P3A, respectively, which causes a defect in exon P3A definition. …”
Publicado 2013
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1292por Lan, Li, Nakajima, Satoshi, Wei, Leizhen, Sun, Luxi, Hsieh, Ching-Lung, Sobol, Robert W., Bruchez, Marcel, Van Houten, Bennett, Yasui, Akira, Levine, Arthur S.“…TetR-KR or TA-KR, bound to a TRE cassette (∼90 kb) integrated at a defined genomic locus in U2OS cells, was used to induce ROS damage in hetero- or euchromatin, respectively. …”
Publicado 2014
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1293“…We show that the large GTPase dynamin2 is enriched in the distal lamellipod where it regulates lamellipodial actin networks as they form and flow in U2-OS cells. Within lamellipodia, dynamin2 regulated the spatiotemporal distributions of α-actinin and cortactin, two actin-binding proteins that specify actin network architecture. …”
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1294por CHEN, BINGPENG, LIU, JINGJING, WU, DANKAI, QIN, YANGUO, PENG, CHUANGANG, LI, CHEN, WANG, JINCHENG“…Furthermore, NOB1 inhibition decreased cell migration and increased E-cadherin and β-catenin expression in U2OS cells. In conclusion, the present study suggested that NOB1 depletion may inhibit osteosarcoma development by increasing E-cadherin and β-catenin expression and, for the first time, indicated the potential of NOB1 as a target in osteosarcoma treatment.…”
Publicado 2014
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1295por Zhang, Ning, Ying, Mei-Dan, Wu, Yong-Ping, Zhou, Zhi-Hong, Ye, Zhao-Ming, Li, Hang, Lin, Ding-Sheng“…In the present study, we investigated the effect of hyperoside, a flavonoid compound, on the osteoblastic differentiation of U2OS and MG63 osteosarcoma cells in vitro. Our results demonstrated that hyperoside inhibits the proliferation of osteosarcoma cells by inducing G(0)/G(1) arrest in the cell cycle, without causing obvious cell death. …”
Publicado 2014
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1296por Mouden, Charlotte, de Tayrac, Marie, Dubourg, Christèle, Rose, Sophie, Carré, Wilfrid, Hamdi-Rozé, Houda, Babron, Marie-Claude, Akloul, Linda, Héron-Longe, Bénédicte, Odent, Sylvie, Dupé, Valérie, Giet, Régis, David, Véronique“…STIL has a role in centriole formation and has previously been described in rare cases of microcephaly. Rescue experiments in U2OS cells showed that the STIL p.Gly717Glu mutation was not able to fully restore the centriole duplication failure following depletion of endogenous STIL protein indicating the deleterious role of the mutation. …”
Publicado 2015
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1297“…To understand the mechanism of action of COX-2 in the pathogenesis of osteosarcoma, we compared gene expression patterns between three stable COX-2-overexpressing cell lines and three control cell lines derived from U2OS human osteosarcoma cells. The data showed that 56 genes were upregulated, whereas 20 genes were downregulated, in COX-2-overexpressed cell lines, with an average fold-change > 1.5. …”
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1298por Musibay, Evidio Domingo, Allen, Cory, Kurokawa, Cheyne, Hardcastle, Jayson J., Aderca, Ileana, Msaouel, Pavlos, Bansal, Aditya, Jiang, Huailei, DeGrado, Timothy R., Galanis, Evanthia“…Cell lines derived from pediatric patients with osteosarcoma (HOS, MG63, 143B, KHOS-312H, U2-OS and SJSA1) were examined for MV-GFP and MV-NIS gene expression and cytotoxicity as defined by syncytial formation, cell death, and eradication of cell monolayers: significant antitumor activity was demonstrated. …”
Publicado 2014
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1299“…In addition, although HeLa cells regulate cyclin C in a manner similar to MEF cells, U2OS osteosarcoma cultures display constitutively cytoplasmic cyclin C and semifragmented mitochondria. …”
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1300por Shirley, Ben C., Mucaki, Eliseos J., Whitehead, Tyson, Costea, Paul I., Akan, Pelin, Rogan, Peter K.“…Mutations and rare SNPs were predicted in genomes of three cancer cell lines (U2OS, U251 and A431), which were supported by expression analyses. …”
Publicado 2013
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