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  1. 121
    “…During splicing of pre-mRNA, 5′ and 3′ splice sites are brought within proximity by interactions between the pre-mRNA bound U1 and U2 snRNPs, followed by recruitment of the tri-snRNP for assembly of the mature spliceosome. …”
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    Identification of a noncanonical RNA binding domain in the U2 snRNP protein SF3A1
  2. 122
    “…U2 auxiliary factor 1 (U2AF1) functions in 3′-splice site selection during pre-mRNA processing. …”
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    mTOR-regulated U2af1 tandem exon splicing specifies transcriptome features for translational control
  3. 123
    “…MATERIAL/METHODS: U2OS cells with CNE9 knockout and U2OS cells with CNE10 knockout were established via the CRISPR/Cas9 system. …”
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    SHOX CNE9/10 Knockout in U2OS Osteosarcoma Cells and Its Effects on Cell Growth and Apoptosis
  4. 124
    “…U2 and U6 small nuclear (sn)RNAs are the only snRNAs directly implicated in catalyzing the splicing of pre-mRNA, but assembly and rearrangement steps prior to catalysis require numerous proteins. …”
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    Role of the central junction in folding topology of the protein-free human U2–U6 snRNA complex
  5. 125
    por Li, Sheng, Cui, Zhengli, Meng, Xianfeng
    Publicado 2016
    “…In this study, the results showed that knockdown of PARP-1 resulted in decreased cell proliferation, increased cell apoptosis, and G(0)/G(1) phase arrest in U2OS cells. In addition, increased expression of active caspase 3 and Bax, but reduced Bcl-2, cyclin D1, and phosphorylated extracellular signal regulated kinase 1/2 (pERK1/2) were observed in PARP-1 knockdown in U2OS cells. …”
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    Knockdown of PARP-1 Inhibits Proliferation and ERK Signals, Increasing Drug Sensitivity in Osteosarcoma U2OS Cells
  6. 126
    “…The modification functions by physically preventing the essential splicing factor U2AF35 from recognizing the 3′ splice site. We propose that use of splice-site m(6)A is an ancient mechanism for splicing regulation.…”
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    Splice site m(6)A methylation prevents binding of U2AF35 to inhibit RNA splicing
  7. 127
    “…In mammals, the structural basis for the interaction between U1 and U2 small nuclear ribonucleoproteins (snRNPs) during the early steps of splicing is still elusive. …”
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    Sequence-specific RNA recognition by an RGG motif connects U1 and U2 snRNP for spliceosome assembly
  8. 128
    por Olivares Córtes, Alfonso
    Publicado 1994
    Tesis Libro
    Prueba hidrostática de la vasija del reactor de la U-2, del proyecto nucleoeléctrico Laguna Verde.
  9. 129
    “…This suggests that the SMN complex stabilizes the association of U1 and U2 snRNPs with pre-mRNA. In addition, the antibody to PRPF40A precipitated U2 snRNPs from nuclear extracts, indicating that PRPF40A associates with U2 snRNPs.…”
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    Functional mammalian spliceosomal complex E contains SMN complex proteins in addition to U1 and U2 snRNPs
  10. 130
    “…We provide evidence that YB-1 activates splicing by facilitating the recruitment of U2AF65 to weak polypyrimidine tracts through direct protein–protein interactions. …”
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    YB-1 binds to CAUC motifs and stimulates exon inclusion by enhancing the recruitment of U2AF to weak polypyrimidine tracts
  11. 131
    “…Quantitative iCLIP data show that the RNA-binding protein hnRNP C competes with the splicing factor U2AF65 at many genuine and cryptic splice sites. …”
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    Direct Competition between hnRNP C and U2AF65 Protects the Transcriptome from the Exonization of Alu Elements
  12. 132
    “…The present study investigated the role of extracellular signal-regulated kinase (ERK) activation in the migratory phenotype of human U2OS osteosarcoma (OS) cells in a collagen matrix. …”
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    Downregulation of ERK signaling impairs U2OS osteosarcoma cell migration in collagen matrix by suppressing MMP9 production
  13. 133
    “…In a previous study, we found that the global genome organizer Special AT-rich binding protein 1 (SATB1) is highly expressed in mesenchymal-derived human osteosarcoma U2OS cells and that the knock-down of SATB1 results in the inhibition of cell proliferation. …”
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    Silencing SATB1 Inhibits the Malignant Phenotype and Increases Sensitivity of Human Osteosarcoma U2OS Cells to Arsenic Trioxide
  14. 134
    “…Here we show that RTEL1 is required for the export and the correct cytoplasmic trafficking of the small nuclear (sn) RNA pre-U2, a component of the major spliceosome complex. …”
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    Human regulator of telomere elongation helicase 1 (RTEL1) is required for the nuclear and cytoplasmic trafficking of pre-U2 RNA
  15. 135
    “…RESULTS: The analysis of HPV11 transcripts in U2OS cells showed that the patterns of promoter use, splice sites and polyadenylation cleavage sites are identical to those previously characterized in human HPV-related lesions, human squamous carcinoma cell lines (e.g., SSC-4) and laryngeal papillomas. …”
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    The transcription map of HPV11 in U2OS cells adequately reflects the initial and stable replication phases of the viral genome
  16. 136
    “…By global profiling of the SRSF3-regulated splicing events in human osteosarcoma U2OS cells, we found that SRSF3 regulates the expression of 60 genes including ERRFI1, ANXA1 and TGFB2, and 182 splicing events in 164 genes, including EP300, PUS3, CLINT1, PKP4, KIF23, CHK1, SMC2, CKLF, MAP4, MBNL1, MELK, DDX5, PABPC1, MAP4K4, Sp1 and SRSF1, which are primarily associated with cell proliferation or cell cycle. …”
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    A genome landscape of SRSF3-regulated splicing events and gene expression in human osteosarcoma U2OS cells
  17. 137
    “…Unlike the NTR, Prp43_Ntr1GP disassembles earlier spliceosomal complexes (A, B, B(act)), indicating that Ntr2/Ntr1-CTD prevents NTR from disrupting properly assembled spliceosomes other than the ILS. The U2 snRNP-intron interaction is disrupted in all complexes by Prp43_Ntr1GP, and in the spliceosome contacts U2 proteins and the pre-mRNA, indicating that the U2 snRNP-intron interaction is Prp43’s major target. …”
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    The target of the DEAH-box NTP triphosphatase Prp43 in Saccharomyces cerevisiae spliceosomes is the U2 snRNP-intron interaction
  18. 138
    “…Human MTX ELISA Kit and MTT assay were used to assess the outcome for osteosarcoma U2OS cells in the present of shock wave and methotrexate. …”
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    Shock wave-induced ATP release from osteosarcoma U2OS cells promotes cellular uptake and cytotoxicity of methotrexate
  19. 139
    por Whisenant, Thomas C
    Publicado 2016
    “…Next, we used RIP-seq to identify the specific genes bound to U2AF2 during T cell activation. After identification of the protein interacting partners of U2AF2, we used splicing sensitive microarrays to measure the effects on global gene expression of using siRNAs to knock down a sampling of these proteins. …”
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    Gene expression profiling of U2AF2 dependent RNA-protein interactions during CD4 + T cell activation
  20. 140
    “…Two U2OS cell samples treated with E2 (15 μmol/L) and two untreated control U2OS cell samples were subjected to RNA-seq. …”
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    RNA sequencing identifies gene expression profile changes associated with β-estradiol treatment in U2OS osteosarcoma cells
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