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  1. 1461
    “…Jmjd6 interacts with splicing factor U2AF25 and GSK3β RNA in the anterior region of Xenopus embryos. …”
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    Jmjd6a regulates GSK3β RNA splicing in Xenopus laevis eye development
  2. 1462
    “…Analysis of the trip averages in the five lines U1, U2, U3, U4 and U6 showed significant differences for PM(10), PM(2.5) and PM(1) (all three mass concentrations: p < 0.001). …”
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    Fine and ultrafine particle exposure during commuting by subway in Vienna
  3. 1463
    “…CLEFMA dose-dependently decreased the cell viabilities of human osteosarcoma U2OS and HOS cells and significantly induced apoptosis in human osteosarcoma cells. …”
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    CLEFMA Activates the Extrinsic and Intrinsic Apoptotic Processes through JNK1/2 and p38 Pathways in Human Osteosarcoma Cells
  4. 1464
    “…Genome-wide libraries directed against all human genes with four designs per gene or eight designs per gene were transduced into U-2 OS cells. These pools were transduced with AAV2 encoding EGFP and sorted based on the intensity of EGFP expression. …”
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    Pooled Screens Identify GPR108 and TM9SF2 as Host Cell Factors Critical for AAV Transduction
  5. 1465
    “…SF3B1 is an essential component of the U2 small nuclear ribonucleoprotein particle that interacts with branch point sequences close to the 3’ splice site during pre-mRNA splicing. …”
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    Human Cancer-Associated Mutations of SF3B1 Lead to a Splicing Modification of Its Own RNA
  6. 1466
    “…Carbon-ion beam irradiation in combination with ZOL significantly inhibited OSA cell proliferation by arresting cell cycle progression and initiating KHOS and U2OS cell apoptosis, compared to treatments with carbon-ion beam irradiation, X-ray irradiation, and ZOL alone. …”
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    Carbon-Ion Beam Irradiation Alone or in Combination with Zoledronic acid Effectively Kills Osteosarcoma Cells
  7. 1467
    “…We found that 138 genes were highly expressed and 86 genes were lowly expressed in highly tumorigenic osteosarcoma cell lines (143B, MNNG/HOS, and SJSA-1) compared with poorly tumorigenic osteosarcoma cell lines (MG-63, Saos-2, and U-2 OS). Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis revealed that highly expressed genes were associated with amino acids and energy metabolism, while lowly expressed genes were associated with cell cycle and DNA replication. …”
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    Identification of tumorigenicity-associated genes in osteosarcoma cell lines based on bioinformatic analysis and experimental validation
  8. 1468
    “…In this work, we use five molecules, grouped into direct versus indirect effectors of the circadian clock, to modulate periods in a human osteosarcoma cell line (U2OS) and determine their influences on cellular behaviors, including motility and colony formation. …”
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    Oncogenic and Circadian Effects of Small Molecules Directly and Indirectly Targeting the Core Circadian Clock
  9. 1469
    “…Alternative splicing was analyzed, showing a significant increase in intron retention in both U2 and U12 intron-containing genes related to cell cycle and mitotic nuclear division. …”
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    Minor Splicing Factors Zrsr1 and Zrsr2 Are Essential for Early Embryo Development and 2-Cell-Like Conversion
  10. 1470
    “…We investigated the effects of Denosumab alone and in combination with Doxorubicin, in two human osteosarcoma cell lines (MG63 and U-2 OS). We evaluated the effect of these treatments on apoptosis, cell cycle progression, invasion capacity and bone metabolism. …”
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    Can Denosumab be used in combination with Doxorubicin in Osteosarcoma?
  11. 1471
    “…The anti-cancer effects of LCS102 were tested on T24, A549, MCF7, PANC-1 and U2OS human cancer cell lines, as were the effects of the formula on doxorubicin, Taxol, etoposide and cisplatin-treated cells using a sulforodamine B viability assay. …”
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    Effect of the botanical compound LCS102 on innate immunity
  12. 1472
    por Xiang, Deng, Li, Yugang, Lin, Yanshui
    Publicado 2020
    “…The abilities cell proliferation and metastatic of U2OS and SW1353 cells were then assessed by Cell Counting Kit-8 and transwell assay, respectively. …”
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    Circular RNA circCCDC66 Contributes to Malignant Phenotype of Osteosarcoma by Sponging miR-338-3p to Upregulate the Expression of PTP1B
  13. 1473
    “…This CCTβ3-dependent mechanism is also present in U2OS, an osteosarcoma cell line, and autophagy and cell survival in starvation are decreased by CCTβ3 depletion. …”
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    Long-term autophagy is sustained by activation of CCTβ3 on lipid droplets
  14. 1474
    “…Using a polydimethylsiloxane open-roof microdevice featuring tapered, fibronectin-coated channels, we followed the migration of U2OS cells through various stages of confinement while simultaneously performing AFM indentation. …”
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    Direct evidence that tumor cells soften when navigating confined spaces
  15. 1475
    “…NSP16 binds to the mRNA recognition domains of the U1 and U2 splicing RNAs and acts to suppress global mRNA splicing upon SARS-CoV-2 infection. …”
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    SARS-CoV-2 Disrupts Splicing, Translation, and Protein Trafficking to Suppress Host Defenses
  16. 1476
    “…The developed inhibitors displayed anti-proliferative properties against various human cancer cell lines in 2D and spheroid cultures and significantly inhibited the migration ability of osteosarcoma U-2 OS cells. Notably, we show that our lead compounds are powerful Haspin inhibitors in human cells, and did not block G2/M cell cycle transition due to improved selectivity against CDK1/CyclinB.…”
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    Design of new disubstituted imidazo[1,2-b]pyridazine derivatives as selective Haspin inhibitors. Synthesis, binding mode and anticancer biological evaluation
  17. 1477
    “…Extension to three cancer cell lines revealed similar results in HeLa cells, whereas DLD1 and U2OS cells could assemble spindles in the absence of centrioles and PCNT-CDK5RAP2, suggesting cell type variation in spindle assembly mechanisms.…”
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    Centriole-independent mitotic spindle assembly relies on the PCNT–CDK5RAP2 pericentriolar matrix
  18. 1478
    por Kuang, Shuzhen, Wang, Liangjiang
    Publicado 2020
    “…When evaluated on two different datasets, human U2OS dataset and mouse ESC dataset, DeepLncCTCF was shown to be able to accurately predict CTCF-binding RNA sites from nucleotide sequence. …”
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    Identification and analysis of consensus RNA motifs binding to the genome regulator CTCF
  19. 1479
    “…[Image: see text] The two La(2)Pd(3)Ge(5) and Nd(2)Pd(3)Ge(5) compounds, crystallizing in the oI40-U(2)Co(3)Ge(5) crystal structure, were targeted for analysis of their chemical bonding and physical properties. …”
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    La(2)Pd(3)Ge(5) and Nd(2)Pd(3)Ge(5) Compounds: Chemical Bonding and Physical Properties
  20. 1480
    “…We found that knocking down PCBP1 resulted in period shortening in human U2OS cells, and that manipulations of PCBP1 expression altered the activity of CLOCK/BMAL1 in an E-box-based reporter assay. …”
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    Identification of PCBP1 as a Novel Modulator of Mammalian Circadian Clock
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