“…The expression of miR-130b inhibited the proliferation of osteosarcoma U-2OS and Saos-2 cells and impaired their ability to migrate, invade and form colonies. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…We report comparable levels of covalency in cerium– and uranium–carbon multiple bonds in the iso-structural carbene complexes [M(BIPM(TMS))(ODipp)(2)] [M = Ce (1), U (2), Th (3); BIPM(TMS) = C(PPh(2)NSiMe(3))(2); Dipp = C(6)H(3)-2,6-(i)Pr(2)] whereas for M = Th the M[double bond, length as m-dash]C bond interaction is much more ionic. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In this study, we investigated the role of Cry1 in regulating proliferation and migration of Hos and U2os human osteosarcoma cells by silencing Cry1 using short hairpin RNA interference. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Furthermore, the expression of embryonic genome activation (EGA) relative genes (eIF1A and U2AF) in HMC embryos derived from ~225% cytoplasm at the 8-cell stages was also found to be enhanced compared with that of the ~75% cytoplasm. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Several categories of splicing aberrations are highlighted, including alterations in cancer-related genes that directly affect their pre-mRNA splicing, mutations in genes encoding splicing factors or core spliceosomal subunits, and the seemingly mutation-free disruptions in the balance of the expression of RNA-binding proteins, including components of both the major (U2-dependent) and minor (U12-dependent) spliceosomes. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…We first identified components associated to the U2 splicing complex (SF3B1, SF3A1, and PHF5A) as required for efficient ex7 inclusion and we confirmed that this exon is fundamental for MBNL1 protein homodimerization. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…To illustrate functionality, the water soluble SQD-N-propylurea-PDI assembly was proven to be nontoxic and efficient for fluorescent imaging of embryonic kidney HEK293 cells and human bone cancerous U2OS cells.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…METHODS: After exposure to oleandrin and/or cisplatin, CCK-8 and colony formation assays, DAPI staining and flow cytometry were performed to detect cell proliferation and apoptosis in 143B, U-2OS and MG-63 osteosarcoma cells. The median-effect analysis was applied to evaluate the combined effect. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Sanguinarine, chelerythrine and chelidonine depolymerized the microtubule network in living cancer cells (Hela cells and human osteosarcoma U2OS cells) and inhibited tubulin polymerization in vitro with IC(50) values of 48.41 ± 3.73, 206.39 ± 4.20 and 34.51 ± 9.47 μM, respectively. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The interactions between selected alkaloids and microtubules were studied via U2OS cells expressing microtubule-GFP markers. RESULTS: The microtubule-binding natural products paclitaxel, vinblastine, colchicine and podophyllotoxin significantly altered microtubule dynamics in living cells and inhibited cell migration at concentrations below apparent cytotoxicity. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Interestingly, it has been shown that Pi greatly enhances the sensitivity of human osteosarcoma cell line (U2OS) to doxorubicin. We investigated the effects of Pi on the sensitivity of TNBC cells to doxorubicin and the underlying molecular mechanisms, carrying out flow cytometry-based assays of cell-cycle progression and cell death, MTT assays, direct cell number counting and immunoblotting experiments. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Overexpression of Let-7b significantly inhibited the proliferation and invasion of U2OS and SAOS-2 cells. A luciferase reporter assay validated that IGF1R was a downstream and functional target of Let-7b. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The curriculum was piloted with two andrology fellowship–trained urology faculty among eight urology residents (PGY2-PGY4/U1-U2) and one medical student. Participants provided feedback regarding the overall course as well as the face and content validity of the simulator. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Small interference RNA (siRNA) specific for FOXO1 was transfected into U2OS cells to knock down FOXO1 expression level. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Previous studies have indicated that MASTL has a critical function in the regulation of mitosis in HeLa and U2OS cell lines, though there is currently limited evidence for the involvement of MASTL in hepatocarcinogenesis. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In G. theta, we identified nucleomorph U1, U2, and U4 spliceosomal small nuclear RNAs (snRNAs) as well as 11 C/D box small nucleolar RNAs (snoRNAs), five of which have potential plant and animal homologs. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In addition, gain‐ and loss‐of‐function experiments demonstrated that miR‐876‐5p restoration suppressed whereas miR‐876‐5p knockdown promoted cell proliferation, migration and invasion in both U2OS and MG63 cells. In vivo studies revealed that miR‐876‐5p overexpression inhibited tumour growth of OS in mice. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…By using cell counting kit-8 (CCK-8) assays, colony formation assays, flow cytometric analyses and Transwell assays, our data suggested that up-regulation of miR-92a promoted the proliferation, migration, and invasion of MNNG and U2OS cells, while inhibiting their apoptosis. In contrast, the knockdown of miR-92a effectively reversed these cellular biological behaviors. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Through both conventional and affinity purification of DRM2, we identified DEAD box RNA helicases U2AF56 Associated Protein 56 (UAP56a/b), which are widespread among eukaryotes, as new DRM2 partners. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Quantitative ratiometric (H3.3/H2B) imaging displayed a concentrated distribution of heterochromatin in the periphery of U2OS cell nuclei. As proof of concept, peripheral heterochromatin responded to experimental manipulation of histone acetylation. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso