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  1. 341
    por Hayes, Barbara, van der Geer, Peter
    Publicado 2023
    “…Both proteins are composed of a UBA domain, an esterase domain, an SH3 domain, and a PGM domain. …”
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    STS-1 and STS-2, Multi-Enzyme Proteins Equipped to Mediate Protein–Protein Interactions
  2. 342
    “…This process termed FAT10ylation is mediated by an enzymatic cascade and includes the E1 activating enzyme ubiquitin-like modifier activating enzyme 6 (UBA6), the E2 conjugating enzyme UBA6-specific E2 enzyme 1 (USE1) and E3 ligases, such as Parkin. …”
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    The ubiquitin-like modifier FAT10 covalently modifies HUWE1 and strengthens the interaction of AMBRA1 and HUWE1
  3. 343
    “…Uba3 (−) (/)− mice died in utero at the periimplantation stage. …”
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    The NEDD8 system is essential for cell cycle progression and morphogenetic pathway in mice
  4. 344
    “…The conjugation machinery consists of the bispecific E1 activating enzyme Ubiquitin-like modifier activating enzyme 6 (UBA6), the likewise bispecific E2 conjugating enzyme UBA6-specific E2 enzyme 1 (USE1), and possibly E3 ligases. …”
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    Conjugation of the Ubiquitin Activating Enzyme UBE1 with the Ubiquitin-Like Modifier FAT10 Targets It for Proteasomal Degradation
  5. 345
    “…VEXAS syndrome (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) is a monogenic disease of adulthood caused by somatic mutations in UBA1 in hematopoietic progenitor cells. Patients develop inflammatory and hematologic symptoms. …”
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    VEXAS syndrome
  6. 346
    por Jitrik, Noé, 1928-
    Publicado 1992
    Libro
    La selva luminosa ; ensayos críticos, 1987-1991 /
  7. 347
    “…URM1 is a ubiquitin-related modifier, and UBA4 is an E1-like enzyme involved in protein urmylation. …”
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    Mechanistic characterization of the sulfur-relay system for eukaryotic 2-thiouridine biogenesis at tRNA wobble positions
  8. 348
    “…We find that S409 phosphorylation destabilizes the UBA dimer interface, and increases binding affinity of p62 to ubiquitin. …”
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    Proteotoxic Stress Induces Phosphorylation of p62/SQSTM1 by ULK1 to Regulate Selective Autophagic Clearance of Protein Aggregates
  9. 349
    “…Consistent with this notion, we find cellular protein levels drastically decreased in an elp3uba4 double mutant and show that this effect as well as growth phenotypes can be partially rescued by excess of tRNA(Lys) (UUU). …”
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    Loss of Anticodon Wobble Uridine Modifications Affects tRNA(Lys) Function and Protein Levels in Saccharomyces cerevisiae
  10. 350
    “…Ddi1 from Saccharomyces cerevisiae additionally contains a ubiquitin-associated (UBA) domain. The substrate specificity and role of the protease domain in the biological functions of the Ddi family remain unclear. …”
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    Structural studies of the yeast DNA damage-inducible protein Ddi1 reveal domain architecture of this eukaryotic protein family
  11. 351
    “…We found here that the ubiquitin-associated (UBA) domain–containing DCNL1 is monoubiquitylated when bound to CRLs and that this monoubiquitylation depends on the CRL-associated Ariadne RBR ligases TRIAD1 (ARIH2) and HHARI (ARIH1) and strictly requires the DCNL1's UBA domain. …”
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    Coupled monoubiquitylation of the co-E3 ligase DCNL1 by Ariadne-RBR E3 ubiquitin ligases promotes cullin-RING ligase complex remodeling
  12. 352
    “…Nevertheless, activation of FAT10 by AOS1/UBA2 does not lead to covalent conjugation of FAT10 with substrate proteins which relies on its cognate E1 enzyme UBA6. …”
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    The ubiquitin-like modifier FAT10 interferes with SUMO activation
  13. 353
    “…Mechanically, acetylation at both K420 and K435 sites enhances p62 binding to ubiquitin by disrupting UBA dimerization, while K435 acetylation also directly increases the UBA-ubiquitin affinity. …”
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    Requirement for p62 acetylation in the aggregation of ubiquitylated proteins under nutrient stress
  14. 354
    por Chen, Yanli, Sun, Ling
    Publicado 2022
    “…So, we concluded that NEDD8, UBA3, UBE2M and RBX1 may serve as the prognostic biomarkers and novel therapeutic targets for AML. …”
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    Inhibition of NEDD8 NEDDylation induced apoptosis in acute myeloid leukemia cells via p53 signaling pathway
  15. 355
    “…UBC and UBC E2 for the group “Natural growth” and “Total”, UBA80 and UBC for the group “Abiotic stresses”. …”
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    Selection of suitable reference genes for qRT-PCR normalisation under different experimental conditions in Eucommia ulmoides Oliv
  16. 356
    “…Six out of 18 tested patients displayed a somatic UBA1 mutation concordant with VEXAS, including one woman. …”
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    USAID Associated with Myeloid Neoplasm and VEXAS Syndrome: Two Differential Diagnoses of Suspected Adult Onset Still’s Disease in Elderly Patients
  17. 357
    “…RESULTS: The mRNA expression levels of RPL34, EIF3A, EIF3G, UBA52, UBC, and FAU were increased in the Saos-2 cells relative to the hFOB1.19 osteoblast cells. …”
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    Knockdown of RPL34 suppresses osteosarcoma cell proliferation likely through EIF3/FAU signaling pathway
  18. 358
    por Zhang, Yue, Dong, Xifeng, Wang, Huaquan
    Publicado 2023
    “…VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) syndrome is a newly defined refractory adult-onset autoinflammatory syndrome caused by somatic mutations in the ubiquitin-like modifier-activating enzyme 1 (UBA1) gene in hematopoietic stem and progenitor cells, resulting in a shift in UBA1 isoform expression. …”
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    VEXAS Syndrome—Review
  19. 359
    “…Here, we report the crystal structure of a fragment of human MELK that contains the kinase domain and ubiquitin-associated (UBA) domain. The UBA domain tightly binds to the back of the kinase domain, which may contribute to the proper conformation and activity of the kinase domain. …”
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    Structural Basis for the Regulation of Maternal Embryonic Leucine Zipper Kinase
  20. 360
    “…The observed data's behavior was assumed to be based on used better than aged in the moment generating function order (UBA(mgf)) characteristic or a constant failure rate in this study (exponential scenario). …”
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    Statistical Modeling of Some Cancerous Diseases Using the Laplace Transform Approach of Basic Life Testing Issues
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