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Mostrando 21 - 40 Resultados de 770 Para Buscar '"UBA"', tiempo de consulta: 0.52s Limitar resultados
  1. 21
    “…UbasM is simple, inexpensive, reproducible and compatible with all labeling methods that we have encountered. …”
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    UbasM: An effective balanced optical clearing method for intact biomedical imaging
  2. 22
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    The ubiquitin-activating enzyme, UBA1, as a novel therapeutic target for AML
  3. 23
    “…Here, we present the crystal structure of UFC1 bound to the C-terminus of UBA5, revealing how UBA5 interacts with UFC1 via a short linear sequence, not observed in other E1-E2 complexes. …”
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    Structural basis for UFM1 transfer from UBA5 to UFC1
  4. 24
    “…Here, we report crystal structures of UBA6 in complex with either ATP or FAT10. In the UBA6-FAT10 complex, the C-terminal domain of FAT10 binds to where ubiquitin resides in the UBA1-ubiquitin complex, however, a switch element ensures the alternate recruitment of either modifier. …”
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    Structures of UBA6 explain its dual specificity for ubiquitin and FAT10
  5. 25
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    Recurrent Mutations of the Active Adenylation Domain of UBA1 in Atypical Form of VEXAS Syndrome
  6. 26
    “…BACKGROUND: Proteins containing ubiquitin-like (UBL) and ubiquitin associated (UBA) domains have been suggested to shuttle ubiquitinated substrates to the proteasome for degradation. …”
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    Yeast UBL-UBA proteins have partially redundant functions in cell cycle control
  7. 27
    “…The C-terminal ubiquitin-associated (UBA) domain of Rad23 functions as a cis-acting stabilization signal that protects this protein from proteasomal degradation. …”
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    C-terminal UBA domains protect ubiquitin receptors by preventing initiation of protein degradation
  8. 28
    “…UBA5 encodes UBA5, the ubiquitin-activating enzyme of UFM1. …”
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    UBA5 Mutations Cause a New Form of Autosomal Recessive Cerebellar Ataxia
  9. 29
    “…Here we showed that Uba52-deficient mice die during embryogenesis. UBA52-deficient cells exhibited normal levels of total ubiquitin. …”
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    The ubiquitin hybrid gene UBA52 regulates ubiquitination of ribosome and sustains embryonic development
  10. 30
    “…These mutations, three missense and one synonymous, all lie within Exon15 of the UBA1 gene, which contains the active adenylation domain (AAD). …”
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    Functional characterizations of rare UBA1 variants in X-linked Spinal Muscular Atrophy
  11. 31
    por Jia, Rui, Bonifacino, Juan S
    Publicado 2019
    “…These findings demonstrate that UBA6 and BIRC6 negatively regulate autophagy by limiting the availability of LC3B. …”
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    Negative regulation of autophagy by UBA6-BIRC6–mediated ubiquitination of LC3
  12. 32
    “…As Myo21 contains two ubiquitin associated (UBA)-like domains (UBLD) in its amino acid sequence, we considered it of interest to analyze the role of these domains in the intracellular distribution and functions of this protein in Leishmania cells. …”
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    Deciphering the role of UBA-like domains in intraflagellar distribution and functions of myosin XXI in Leishmania
  13. 33
    “…Recent reports indicate that the inhibition of ubiquitin-like modifier-activating enzyme 5 (UBA5) can impede tumor development. However, there have been few reports regarding UBA5-inhibiting compounds. …”
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    Inhibition of UBA5 Expression and Induction of Autophagy in Breast Cancer Cells by Usenamine A
  14. 34
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    The First Korean Case of VEXAS Syndrome Caused by a UBA1 Somatic Variant
  15. 35
    “…Therefore, we hypothesized that TAK-243, the first-in-class UBA1 inhibitor, might increase GBM sensitivity to radiation. …”
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    UBA1 inhibition contributes radiosensitization of glioblastoma cells via blocking DNA damage repair
  16. 36
    “…Protein UFMylation downstream of the E1 enzyme UBA5 plays essential roles in development and ER stress. …”
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    Allelic strengths of encephalopathy-associated UBA5 variants correlate between in vivo and in vitro assays
  17. 37
    “…In VEXAS syndrome, both aberrant inflammation and myeloid predominance appear intrinsic to hematopoietic stem cells mutated in UBA1.…”
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    Early activation of inflammatory pathways in UBA1-mutated hematopoietic stem and progenitor cells in VEXAS
  18. 38
    “…In silico analysis predicted three ubiquitin binding domains (UBDs) at the N-terminus: one ubiquitin-associated domain (UBA) and two ubiquitin-interacting motifs (UIMs), whereas no clear structural homology at the extended C-terminal region outside the catalytic domains were detected. …”
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    The UBA-UIM Domains of the USP25 Regulate the Enzyme Ubiquitination State and Modulate Substrate Recognition
  19. 39
    “…Previous studies suggested that the large class of ubiquitin associated (UBA) domains contains members with intrinsic specificity for lysine 63-linked polyUb (K63-polyUb) or K48-polyUb, thus explaining how UBA-containing proteins can mediate diverse signaling events. …”
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    Avid interactions underlie the K63-linked polyubiquitin binding specificities observed for UBA domains
  20. 40
    “…Activation of MPK38 requires the extended sequence (ExS) containing the ubiquitin-associated (UBA) linker and UBA domain and phosphorylation of the activation loop. …”
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    The structures of the kinase domain and UBA domain of MPK38 suggest the activation mechanism for kinase activity
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