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Mostrando 401 - 420 Resultados de 770 Para Buscar '"UBA"', tiempo de consulta: 0.23s Limitar resultados
  1. 401
    “…In this study, we elucidated the roles of four SUMOylation‐associated genes that encode one SUMO protein (MoSMT3), two E1 enzymes (MoAOS1 and MoUBA2) and one E2 enzyme (MoUBC9) in fungal development and pathogenicity. …”
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    SUMOylation is required for fungal development and pathogenicity in the rice blast fungus Magnaporthe oryzae
  2. 402
    “…Here, we present crystal structures of Cdc34 alone and in complex with E1, and a Cdc34~Ub thioester mimetic that represents the product of Uba1-Cdc34 Ub transthiolation. These structures reveal conformational changes in Uba1 and Cdc34 and a unique binding mode that are required for transthiolation. …”
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    Structural insights into E1 recognition and the ubiquitin-conjugating activity of the E2 enzyme Cdc34
  3. 403
    por Bijlmakers, Marie-José
    Publicado 2021
    “…In addition, the targeting of the key enzyme in ubiquitination, the ubiquitin E1 UBA1, is discussed as an alternative strategy. Important differences between human and trypanosomatid UBA1s in susceptibility to inhibitors predicts that the selective targeting of these enzymes in trypanosomatids may also be feasible. …”
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    Ubiquitination and the Proteasome as Drug Targets in Trypanosomatid Diseases
  4. 404
    “…Then, UA, UBA, and UBE dissolved in 1% dimethyl sulfoxide (DMSO) and diluted in four concentrations were tested for their toxicity on human blood cells. …”
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    Usnic Acid and Usnea barbata (L.) F.H. Wigg. Dry Extracts Promote Apoptosis and DNA Damage in Human Blood Cells through Enhancing ROS Levels
  5. 405
    “…A recent study demonstrated that the dermal infiltrate in neutrophilic dermatosis from VEXAS patients is derived from the pathological UBA1-mutated myeloid clone. Neutrophilic dermatosis is, however, only one of the various skin involvements observed in VEXAS syndrome. …”
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    Distinction between clonal and paraclonal cutaneous involvements in VEXAS syndrome
  6. 406
    “…During viral infection, mutations of either NOD2 or UBA1 genes or in combination can facilitate autoinflammatory disease. …”
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    SARS-CoV-2/COVID-19 and its relationship with NOD2 and ubiquitination
  7. 407
    “…Besides, through PPI network analysis, genes with higher connectivity such as UBA52, RPLP0, RPL3, RPLP2, and RPL27 were also identified, suggesting that they play important regulatory roles in the complex network associated with LDH. …”
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    Comprehensive analysis of molecular pathways and key genes involved in lumbar disc herniation
  8. 408
    “…Our results illustrate the role of the Uba4‐Urm1 system as a key evolutionary link between prokaryotic SCPs and the UBL modifications observed in modern eukaryotes.…”
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    E2/E3‐independent ubiquitin‐like protein conjugation by Urm1 is directly coupled to cysteine persulfidation
  9. 409
    “…We show that p97(Ufd1-Npl4) recruitment to CMG requires the UBA-UBX protein Ubxn7, and conversely, stable Ubxn7 binding to CMG requires p97(Ufd1-Npl4). …”
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    Cooperative assembly of p97 complexes involved in replication termination
  10. 410
    “…We used gene essentiality measurements in 1,086 cancer cell lines to identify selective coessentiality modules and found that a ubiquitin ligase complex composed of UBA6, BIRC6, KCMF1, and UBR4 is required for the survival of a subset of epithelial tumors that exhibit a high degree of aneuploidy. …”
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    A Ubiquitination Cascade Regulating the Integrated Stress Response and Survival in Carcinomas
  11. 411
    Publicado 1998
    Libro
    Los derechos del niño en la familia : discurso y realidad /
  12. 412
    “…Supplementation with 500 ng/mL PRL significantly increased the proteins of MT-ND1, MAPK12, UBA52 and BCL2L1, which were enriched in ROS and mitophagy pathways. …”
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    Effect of prolactin on cytotoxicity and oxidative stress in ovine ovarian granulosa cells
  13. 413
    “…Western blot demonstrated that levels of the UBA1 protein did not differ between the leukemia and normal cells. …”
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    Potential biomarkers for adult acute myeloid leukemia minimal residual disease assessment searched by serum peptidome profiling
  14. 414
    “…A difference in expression level greater than 1.5-fold was detected for nine genes: MGMT, ERCC4, FANCB, UBA1, XRCC5, XPA, XPC, PARP3, and RPA1. The non-homologous end joining and nucleotide excision repair pathways of DNA repair showed the most significant relevance. …”
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    Pathological complete response after cisplatin neoadjuvant therapy is associated with the downregulation of DNA repair genes in BRCA1-associated triple-negative breast cancers
  15. 415
    “…We now show that CRAM-1 contains three α-helical segments forming a UBA-like domain, structurally similar to those of mammalian adaptor proteins (e.g. …”
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    Structural insights into pro-aggregation effects of C. elegans CRAM-1 and its human ortholog SERF2
  16. 416
    “…OBJECTIVES: To prospectively evaluate the impact of tylosin administration on fecal microbiota and unconjugated bile acids (UBAs) over time. ANIMALS: Sixteen healthy adult dogs. …”
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    Long‐term impact of tylosin on fecal microbiota and fecal bile acids of healthy dogs
  17. 417
    “…From these DEGs, 17 hub genes were identified including 12 upregulated genes (UBE2C, UBC, CDC34, UBR1, KIF11, ASF1B, PRC1, ESPL1, GTSE1, EXO1, UBA1, KIF4A) and 5 downregulated genes (UBA52, UBE2V2, SKP1, CCNB1, MAD2L1). …”
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    Single‐cell transcriptome analysis of human oocyte ageing
  18. 418
    “…Finally, decreased KIF22 and PYGL levels had good survival outcomes for PDAC. Four genes (RPS27A, UBA52, KIF22 and PYGL) might be involved in the pathogenesis of diabetic PDAC. …”
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    Identification of Key Genes Involved in Pancreatic Ductal Adenocarcinoma with Diabetes Mellitus Based on Gene Expression Profiling Analysis
  19. 419
    “…METHODS: The ubiquitin-protein and the ubiquitin coding gene UBA52, UBA80, UBB, and UBC expressions were detected in clinical tissues and cells. …”
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    UBC Mediated by SEPT6 Inhibited the Progression of Prostate Cancer
  20. 420
    “…PfHz treatment for 24 h significantly altered expression for 14 genes: 12 were down-regulated (ANAPC11, BRCC3, CUL4B, FBXO4, MIB1, SKP2, TP53, UBA2, UBA3, UBE2G1, UBE2G2, and WWP1), while 2 were up-regulated (UBE2J1 and UBE2Z). …”
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    Ingestion of hemozoin by peripheral blood mononuclear cells alters temporal gene expression of ubiquitination processes
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