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Mostrando 421 - 440 Resultados de 770 Para Buscar '"UBA"', tiempo de consulta: 0.26s Limitar resultados
  1. 421
    “…Sequencing of ubiquitin‐activating enzyme E1 (UBA‐1) was performed using genomic DNA from peripheral blood leukocytes or bone marrow tissue. …”
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    VEXAS Syndrome: A Case Series From a Single‐Center Cohort of Italian Patients With Vasculitis
  2. 422
    “…Furthermore, the structure unveils multiple Ub-binding surfaces on the UBA domain that allow distinct binding modes for K48- and K63-linked Ub chains. …”
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    Structure of UBE2K–Ub/E3/polyUb reveals mechanisms of K48-linked Ub chain extension
  3. 423
    “…Most notably, the expression of UFM1 and its conjugating machinery (i.e., UBA5, UFC1, UFL1, and UFBP1) were dramatically upregulated in ERα-positive breast cancer cell lines and tissues. …”
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    Modification of ERα by UFM1 Increases Its Stability and Transactivity for Breast Cancer Development
  4. 424
    “…Several crucial genes, including TP53, MYC, CDND1, IL6, UBA52, EZH2, and MDM2, are significantly correlated with MM, which may exert their role in the onset and evolution of MM.…”
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    Multiple Myeloma: Bioinformatic Analysis for Identification of Key Genes and Pathways
  5. 425
    “…A total of 12 reference genes (Actb, Actg1, Ubc, Uba1, Uba52, Ube2c, Tuba1a, Tuba1b, Tubb5, H2afy, H2afx and Gapdh) from 430 candidates involving tubulin, histone, actin, ubiquitin and GAPDH family members were screened via transcriptome sequencing (RNA-seq) analysis. …”
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    Validation of superior reference genes in mouse submandibular glands under developmental and functional regeneration states
  6. 426
    “…Distinct gut bacterial communities were observed between rodent host genera, with broadly distributed species originating from the as-yet-uncultured bacterial genera UBA9475 and UBA2821 in the families Oscillospiraceae and Lachnospiraceae, respectively. …”
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    Effects of laboratory domestication on the rodent gut microbiome
  7. 427
    “…Having VEXAS syndrome in mind, genetic testing identifying the UBA1 gene mutation was performed, thus confirming our suspicion. …”
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    VEXAS Syndrome in a Patient with Myeloproliferative Neoplasia
  8. 428
    “…The Ufm1 conjugation system is an ubiquitin-like modification system that consists of Ufm1, Uba5 (E1), Ufc1 (E2), and less defined E3 ligase(s) and targets. …”
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    UFBP1, a Key Component of the Ufm1 Conjugation System, Is Essential for Ufmylation-Mediated Regulation of Erythroid Development
  9. 429
    “…CONCLUSIONS: LncRNAs LINC00917, CTD-2246P4.1, CTC-523E23.5, RP4-639J15.1, RP11-363G2.4, AC005082.12, MIR132, and RP11-38F22.1 were differentially expressed and might play important roles in the development of IDD. Key genes, such as UBA52 and SPHK1, may be pivotal biomarkers for IDD.…”
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    Potential Role of lncRNAs in Contributing to Pathogenesis of Intervertebral Disc Degeneration Based on Microarray Data
  10. 430
    “…Consequently, HSV-1-induced early phase IFN-β production significantly decreased upon MLN4924 treatment and UBA3 deficiency. NF-κB inhibitor JSH-23 mimicked the effects of neddylation inhibition in the early phase of HSV-1 infection. …”
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    Neddylation is required for herpes simplex virus type I (HSV-1)-induced early phase interferon-beta production
  11. 431
    “…There are five key domains in the USP5 protein and subsequent studies revealed that the cryptic ZnF domain and the C-box domain interacted with c-Maf but the UBA1/UBA2 domain partly increased its stability. …”
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    Inhibition of the deubiquitinase USP5 leads to c-Maf protein degradation and myeloma cell apoptosis
  12. 432
    “…The recent finding that biallelic mutations in UBA5 (the E1-like enzyme for ufmylation) cause severe early-onset encephalopathy with progressive microcephaly implicates ufmylation in human brain development. …”
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    Biallelic UFM1 and UFC1 mutations expand the essential role of ufmylation in brain development
  13. 433
    “…Remarkably, we identified six chromatin state-marked C1-FFL instances (HCFC1-NFYA-ABL1, THAP1-USF1-BRCA2, ZNF263-USF1-UBA52, MYC-ATF1-UBA52, ELK1-EGR1-CCT4, and YY1-EGR1-INO80C) could act as prognostic biomarkers of acute myelogenous leukemia though influencing cancer-related biological functions, such as cell proliferation, telomere maintenance, and DNA recombination. …”
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    Identifying functions and prognostic biomarkers of network motifs marked by diverse chromatin states in human cell lines
  14. 434
    “…Despite a ten-fold increase in UBA procedures logged by trainees, the decline in MUS has resulted in a major reduction in total SUI surgeries. …”
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    Contemporary trends for urological training and management of stress urinary incontinence in Ireland
  15. 435
    “…In particular, the common autoAg UBA1 that catalyzes the first step in ubiquitination is encoded by an X-chromosome escape gene. …”
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    A Master Autoantigen-ome Links Alternative Splicing, Female Predilection, and COVID-19 to Autoimmune Diseases
  16. 436
    “…Then, GPRIN1, MYRF, PLXNB2, SLC9A4, TRIM29, UBA6, and XDH are potential LUAD-related immune biomarker candidates to activate the immune response. …”
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    Potential Immune Biomarker Candidates and Immune Subtypes of Lung Adenocarcinoma for Developing mRNA Vaccines
  17. 437
    “…Subsequently, immunoprecipitation assay to evaluate the degradation of HistoneH2A isomers by UBA52 ubiquitylation. Transmission electron microscopy (TEM) was applied to observe the structure change of mitochondria and autophagosome. …”
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    Dcf1 induces glioblastoma cells apoptosis by blocking autophagy
  18. 438
    “…In particular, the common autoAg UBA1 that catalyzes the first step in ubiquitination is encoded by an X-chromosome escape gene. …”
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    A master autoantigen-ome links alternative splicing, female predilection, and COVID-19 to autoimmune diseases
  19. 439
    “…And the identified 5 proteins (UBA1, EIF3E, RPL17, RPL27, and RPS28) may serve as potential biomarkers to predict the severity of tHO. …”
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    Comparative proteomic analysis identifies differentially expressed proteins and reveals potential mechanisms of traumatic heterotopic ossification progression
  20. 440
    “…The extracts in acetone, 96% ethanol, and water with the same dried lichen/solvent ratio (w/v) were obtained through two conventional techniques: maceration (mUBA, mUBE, and mUBW) and Soxhlet extraction (dUBA, dUBE, and dUBW). …”
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    Phenolic Secondary Metabolites and Antiradical and Antibacterial Activities of Different Extracts of Usnea barbata (L.) Weber ex F.H.Wigg from Călimani Mountains, Romania
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