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Mostrando 501 - 520 Resultados de 770 Para Buscar '"UBA"', tiempo de consulta: 0.34s Limitar resultados
  1. 501
    “…Since its main function is to modify tRNA, Urm1 acts in a non-canonical manner. Uba4, the activating enzyme of Urm1, contains two domains: a classical E1-like domain (AD), which activates Urm1, and a rhodanese homology domain (RHD). …”
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    Urm1: A Non-Canonical UBL
  2. 502
    por Jia, Rui, Bonifacino, Juan S.
    Publicado 2021
    “…Previous studies showed that monoubiquitination of LC3B catalyzed by the ubiquitin-activating enzyme UBA6 and ubiquitin-conjugating enzyme/ubiquitin ligase BIRC6 targets LC3B for proteasomal degradation, thus reducing LC3B levels and autophagic activity under conditions of stress. …”
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    The ubiquitin isopeptidase USP10 deubiquitinates LC3B to increase LC3B levels and autophagic activity
  3. 503
    por Liu, Jing, Li, Jian, Wang, Zhi, Yang, Hua
    Publicado 2022
    “…The ribosomal signaling pathway and rpl23a, uba52 are critical pathways and essential genes that affect the fecundity of snails. …”
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    Transcriptome Sequencing and Bioinformatics Analysis of Ovarian Tissues from Pomacea canaliculata in Guangdong and Hunan
  4. 504
    “…Copy number alterations in LMCD1-A1S and GRM7, the methylation status of CEACAM19, KRT17, and ST18, and the expression profile of RPL29, UBA7, FCGR2C, and RPSAP58 can predict the HNC patients’ survival. …”
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    Integrated Multi-Omics Signature Predicts Survival in Head and Neck Cancer
  5. 505
    por Gao, Wei, Wang, Lei, Qu, Lianzheng
    Publicado 2022
    “…At present, the unused bandwidth allocation (UBA) method is commonly used to address the bandwidth constraint in the DRM problem. …”
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    Research on Joint Resource Allocation for Multibeam Satellite Based on Metaheuristic Algorithms
  6. 506
    “…Recently developed small-molecule inhibitors of SUMOylation (SUMOi) target the heterodimeric E1 SUMO activation complex (SAE1/UBA2). Here, we report that activated MYC signaling is an actionable molecular vulnerability in vitro and in a preclinical murine in vivo model of MYC-driven BCL. …”
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    Small-molecule SUMO inhibition for biomarker-informed B-cell lymphoma therapy
  7. 507
    “…In this review, we first summarize the core enzymes and factors involved in the UFMylation cascade, which, similar to ubiquitin, is consecutively catalyzed by UFM1-activating enzyme 5 (UBA5), UFM1-conjugating enzyme 1 (UFC1) and UFM1-specific ligase 1 (UFL1). …”
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    Emerging role of UFMylation in secretory cells involved in the endocrine system by maintaining ER proteostasis
  8. 508
    “…A prognostic signature containing four LI-m6As (AC010894.3, ACAP2-IT1, CACNA1G-AS1, and UBA6-AS1) was constructed according to the LASSO Cox regression analysis of the 10 LI-m6As. …”
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    Identification and validation of lncRNAs involved in m6A regulation for patients with ovarian cancer
  9. 509
    “…The high-fat diet decreased the abundances of UBA1819 at 9 weeks, and Gastranaerophilales, Clostridia UCG-014, and ASF356 at 9 and 18 weeks. …”
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    The Gut Microbiome Responds Progressively to Fat and/or Sugar-Rich Diets and Is Differentially Modified by Dietary Fat and Sugar
  10. 510
    “…SQSTM1/p62 interacts with Twist1 via the UBA domain of p62, in a Twist1-ubiquitination-dependent manner. …”
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    Autophagy regulates tumor growth and metastasis
  11. 511
    “…Interestingly, AIPL1 also co-immunoprecipitated the E1 activating enzyme for FAT10, UBA6, suggesting AIPL1 may have a role in directly regulating the FAT10 conjugation machinery. …”
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    The Inherited Blindness Protein AIPL1 Regulates the Ubiquitin-Like FAT10 Pathway
  12. 512
    “…Finally, we show that both the PB1 and UBA domains of Ref(2)P are crucial for mitochondrial clustering. …”
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    Drosophila ref(2)P is required for the parkin-mediated suppression of mitochondrial dysfunction in pink1 mutants
  13. 513
    “…Ubiquitin-associated protein 2-like (UBAP2L), which contains a ubiquitin-associated (UBA) domain near its N-terminus, has been indicated in the pathogenesis of several human cancers, including multiple myeloma, hepatocellular carcinoma and malignant ovarian tumors. …”
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    Downregulation of ubiquitin-associated protein 2-like with a short hairpin RNA inhibits human glioma cell growth in vitro
  14. 514
    “…To validate these findings, we confirmed several sumoylation sites of Aos1 and Uba2 in vivo. Together, these results demonstrate that our chemical and enzymatic method for identifying protein sumoylation sites provides a useful tool and that a combination of methods allows a detailed analysis of protein sumoylation sites.…”
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    A Chemical and Enzymatic Approach to Study Site-Specific Sumoylation
  15. 515
    “…PRINCIPAL FINDINGS: Samples from sera (n = 1189) collected from four Local Government Areas in Borno State (Askira/Uba, Damboa, Jere and Maiduguri) were assessed for the presence of IgG and IgM antibodies. …”
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    Serological and Virological Evidence of Crimean-Congo Haemorrhagic Fever Virus Circulation in the Human Population of Borno State, Northeastern Nigeria
  16. 516
    “…MsrA catalyzes this Ubl modification activity, with the Ubl-activating E1 UbaA, in the presence of the mild oxidant dimethyl sulfoxide (DMSO) and in the absence of reductant. …”
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    Methionine Sulfoxide Reductase A (MsrA) and Its Function in Ubiquitin-Like Protein Modification in Archaea
  17. 517
    “…The HECT-type ubiquitin ligase HECT, UBA and WWE Domain Containing 1, (HUWE1) regulates key cancer-related pathways, including the Myc oncogene. …”
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    Drosophila HUWE1 Ubiquitin Ligase Regulates Endoreplication and Antagonizes JNK Signaling During Salivary Gland Development
  18. 518
    “…We found dependency on the ubiquitylation machinery including the ubiquitin-activating enzyme Uba1, the ubiquitin-­conjugating enzymes Ubc6 and Ubc7, and the ubiquitin–protein ligase Doa10. …”
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    Degradation of integral membrane proteins modified with the photosensitive degron module requires the cytosolic endoplasmic reticulum–associated degradation pathway
  19. 519
    “…The most susceptible cultivars to anthracnose were Ubà, Quinzenga, Amarelinha da Sementeira followed by Aroeira and Correjo, whereas Mallika followed by Ourinho and Lita resulted in the least susceptible cultivars. …”
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    Cultivar Resistance against Colletotrichum asianum in the World Collection of Mango Germplasm in Southeastern Brazil
  20. 520
    “…This data compendium is freely available as a web server (http://target.sbg.qb.fcen.uba.ar/). MAIN CONCLUSION: This work represents an effort to reduce the costs in the first phases of B. bacilliformis drug discovery.…”
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    Prioritisation of potential drug targets against Bartonella bacilliformis by an integrative in-silico approach
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