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367741por Penny, Melissa A, Verity, Robert, Bever, Caitlin A, Sauboin, Christophe, Galactionova, Katya, Flasche, Stefan, White, Michael T, Wenger, Edward A, Van de Velde, Nicolas, Pemberton-Ross, Peter, Griffin, Jamie T, Smith, Thomas A, Eckhoff, Philip A, Muhib, Farzana, Jit, Mark, Ghani, Azra C“…FUNDING: PATH Malaria Vaccine Initiative; Bill & Melinda Gates Foundation; Global Good Fund; Medical Research Council; UK Department for International Development; GAVI, the Vaccine Alliance; WHO.…”
Publicado 2016
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367742por Paton, Nicholas I, Stöhr, Wolfgang, Arenas-Pinto, Alejandro, Fisher, Martin, Williams, Ian, Johnson, Margaret, Orkin, Chloe, Chen, Fabian, Lee, Vincent, Winston, Alan, Gompels, Mark, Fox, Julie, Scott, Karen, Dunn, David T“…METHODS: In this pragmatic, parallel-group, randomised, controlled, open-label, non-inferiority trial, we enrolled adults (≥18 years of age) positive for HIV attending 43 public sector treatment centres in the UK who had suppressed viral load (<50 copies per mL) for at least 24 weeks on combination ART with no change in the previous 12 weeks and a CD4 count of more than 100 cells per μL. …”
Publicado 2015
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367743por Forbes, John F, Sestak, Ivana, Howell, Anthony, Bonanni, Bernardo, Bundred, Nigel, Levy, Christelle, von Minckwitz, Gunter, Eiermann, Wolfgang, Neven, Patrick, Stierer, Michael, Holcombe, Chris, Coleman, Robert E, Jones, Louise, Ellis, Ian, Cuzick, Jack“…FUNDING: Cancer Research UK, National Health and Medical Research Council Australia, Breast Cancer Research Fund, AstraZeneca, Sanofi Aventis.…”
Publicado 2016
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367744por Willis, Thomas A., Hartley, Suzanne, Glidewell, Liz, Farrin, Amanda J., Lawton, Rebecca, McEachan, Rosemary R. C., Ingleson, Emma, Heudtlass, Peter, Collinson, Michelle, Clamp, Susan, Hunter, Cheryl, Ward, Vicky, Hulme, Claire, Meads, David, Bregantini, Daniele, Carder, Paul, Foy, Robbie“…Clusters are general practices in West Yorkshire, United Kingdom (UK), recruited using an ‘opt-out’ recruitment process. …”
Publicado 2016
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367745por Jefferis, Barbara J., Parsons, Tessa J., Sartini, Claudio, Ash, Sarah, Lennon, Lucy T., Wannamethee, S. Goya, Lee, I-Min, Whincup, Peter H.“…METHODS: Cross-sectional study of men (71–91 years) recruited in UK primary care centres. Nurses made physical measures (weight, height, bio-impedance, blood pressure) and took fasting blood samples. 1528/3137 (49 %) surviving men had ≥3 valid days (≥600 min) accelerometer data. 450 men with pre-existing chronic disease were excluded. 1009/1078 (93.6 %) had complete covariate data. …”
Publicado 2016
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367746por Dolling, David I., Desai, Monica, McOwan, Alan, Gilson, Richard, Clarke, Amanda, Fisher, Martin, Schembri, Gabriel, Sullivan, Ann K., Mackie, Nicola, Reeves, Iain, Portman, Mags, Saunders, John, Fox, Julie, Bayley, Jake, Brady, Michael, Bowman, Christine, Lacey, Charles J., Taylor, Stephen, White, David, Antonucci, Simone, Gafos, Mitzy, McCormack, Sheena, Gill, Owen N., Dunn, David T., Nardone, Anthony“…Of all participants, 217 (40 %) were born outside the UK. A sexually transmitted infection (STI) was reported to have been diagnosed in the previous 12 months in 330/515 (64 %) and 473/544 (87 %) participants reported ever having being diagnosed with an STI. …”
Publicado 2016
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367747“…TRIAL REGISTRATION: PROSPERO International Prospective Register of Systematic Reviews: CRD42015024731; http://www.crd.york.ac.uk/PROSPERO/display_record.asp?ID=CRD42015024731 (Archived by WebCite at http://www.webcitation.org/6dV1Cin91).…”
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367748por Gregson, Celia L, Wheeler, Lawrie, Hardcastle, Sarah A, Appleton, Louise H, Addison, Kathryn A, Brugmans, Marieke, Clark, Graeme R, Ward, Kate A, Paggiosi, Margaret, Stone, Mike, Thomas, Joegi, Agarwal, Rohan, Poole, Kenneth ES, McCloskey, Eugene, Fraser, William D, Williams, Eleanor, Bullock, Alex N, Davey Smith, George, Brown, Matthew A, Tobias, Jon H, Duncan, Emma L“…A total of 258 unrelated HBM cases were identified from a review of 335,115 DXA scans from 13 UK centers. Cases were assessed clinically and underwent sequencing of known anabolic HBM loci: LRP5 (exons 2, 3, 4), LRP4 (exons 25, 26), SOST (exons 1, 2, and the van Buchem's disease [VBD] 52‐kb intronic deletion 3′). …”
Publicado 2015
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367749“…This is the official guideline endorsed by the specialty associations involved in the care of head and neck cancer patients in the UK. Recurrent cancers present some of the most challenging management issues in head and neck surgical and oncological practice. …”
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367750por Brown, James, Clark, Kristina, Smith, Colette, Hopwood, Jennifer, Lynard, Oliver, Toolan, Michael, Creer, Dean, Barker, Jack, Breen, Ronan, Brown, Tim, Cropley, Ian, Lipman, Marc“…METHODS: People treated for TB at four London, UK sites between 2003 and 2014 were assessed and data collected on the following characteristics: baseline CRP level; demographics (ethnicity, gender and age); HIV status; site of TB disease; sputum smear (in pulmonary cases) and culture results. …”
Publicado 2016
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367751por Gamble, John-Michael, Thomas, Jamie M., Twells, Laurie K., Midodzi, William K., Majumdar, Sumit R.“…We conducted a cohort study using the UK-based Clinical Practice Research Datalink. Participants included a cohort of 38,233 new users of metformin monotherapy who initiated a 2nd antidiabetic agent between January 1, 2007 and December 31, 2012 with follow-up until death, disenrollment, therapy discontinuation, or study end-date. …”
Publicado 2016
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367752por Cooper, Sally-Ann, Ademola, Temitope, Caslake, Muriel, Douglas, Elizabeth, Evans, Jonathan, Greenlaw, Nicola, Haig, Caroline, Hassiotis, Angela, Jahoda, Andrew, McConnachie, Alex, Morrison, Jill, Ring, Howard, Starr, John, Stiles, Ciara, Sirisena, Chammy, Sullivan, Frank“…CONCLUSION: A full-scale RCT is feasible. It will need 37 % UK population coverage to recruit the required 160 participants. …”
Publicado 2016
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367753por Rojo, Federico, González-Pérez, Abel, Furriol, Jessica, Nicolau, Ma Jesús, Ferrer, Jaime, Burgués, Octavio, Sabbaghi, MohammadA, González-Navarrete, Irene, Cristobal, Ion, Serrano, Laia, Zazo, Sandra, Madoz, Juan, Servitja, Sonia, Tusquets, Ignasi, Albanell, Joan, Lluch, Ana, Rovira, Ana, Eroles, PilarEnlace del recurso
Publicado 2016
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367754por Jones, Samuel E., Tyrrell, Jessica, Wood, Andrew R., Beaumont, Robin N., Ruth, Katherine S., Tuke, Marcus A., Yaghootkar, Hanieh, Hu, Youna, Teder-Laving, Maris, Hayward, Caroline, Roenneberg, Till, Wilson, James F., Del Greco, Fabiola, Hicks, Andrew A., Shin, Chol, Yun, Chang-Ho, Lee, Seung Ku, Metspalu, Andres, Byrne, Enda M., Gehrman, Philip R., Tiemeier, Henning, Allebrandt, Karla V., Freathy, Rachel M., Murray, Anna, Hinds, David A., Frayling, Timothy M., Weedon, Michael N.“…We performed genome-wide association studies of self-reported chronotype (morning/evening person) and self-reported sleep duration in 128,266 white British individuals from the UK Biobank study. Sixteen variants were associated with chronotype (P<5x10(-8)), including variants near the known circadian rhythm genes RGS16 (1.21 odds of morningness, 95% CI [1.15, 1.27], P = 3x10(-12)) and PER2 (1.09 odds of morningness, 95% CI [1.06, 1.12], P = 4x10(-10)). …”
Publicado 2016
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367755por Campanilho‐Marques, Raquel, Almeida, Beverley, Deakin, Claire, Arnold, Katie, Gallot, Natacha, de Iorio, Maria, Nistala, Kiran, Pilkington, Clarissa A., Wedderburn, Lucy R., Armon, Kate, Ellis‐Gage, Joe, Roper, Holly, Briggs, Vanja, Watts, Joanna, McCann, Liza, Roberts, Ian, Baildam, Eileen, Hanna, Louise, Lloyd, Olivia, Riley, Phil, McGovern, Ann, Ryder, Clive, Scott, Janis, Thomas, Beverley, Southwood, Taunton, Al‐Abadi, Eslam, Wyatt, Sue, Jackson, Gillian, Amin, Tania, Wood, Mark, VanRooyen, Vanessa, Burton, Deborah, Davidson, Joyce, Gardner‐Medwin, Janet, Martin, Neil, Ferguson, Sue, Waxman, Liz, Browne, Michael, Friswell, Mark, Foster, Helen, Swift, Alison, Jandial, Sharmila, Stevenson, Vicky, Wade, Debbie, Sen, Ethan, Smith, Eve, Qiao, Lisa, Watson, Stuart, Venning, Helen, Satyapal, Rangaraj, Stretton, Elizabeth, Jordan, Mary, Mosley, Ellen, Frost, Anna, Crate, Lindsay, Warrier, Kishore, Wedderburn, Lucy, Pilkington, Clarissa, Hasson, Nathan, Nistala, Kiran, Maillard, Sue, Halkon, Elizabeth, Brown, Virginia, Juggins, Audrey, Smith, Sally, Lunt, Sian, Enayat, Elli, Varsani, Hemlata, Kassoumeri, Laura, Beard, Laura, Arnold, Katie, Glackin, Yvonne, Simou, Stephanie, Campanilho‐Marques, Raquel, Almeida, Beverley, Murray, Kevin, Ioannou, John, Suffield, Linda, Al‐Obaidi, Muthana, Lee, Helen, Leach, Sam, Smith, Helen, Wilkinson, Nick, Inness, Emma, Kendall, Eunice, Mayers, David, Clinch, Jacqui, Pluess‐Hall, Helen“…METHODS: A total of 71 patients recruited to the UK Juvenile Dermatomyositis Cohort and Biomarker Study were included and assessed for skin disease using the CAT, DAS, MITAX, and skin VAS. …”
Publicado 2016
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367756“…Development: using a multiple case study approach, we collected trialist interviews (n = 7), trial publications (n = 16) and diaries (n = 7) from seven purposively sampled UK rehabilitation trials. We explored return rates, diary designs and trialists’ ideas as to what affected diary completion and validity. …”
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367757por Lewandowski, Iris, Clifton-Brown, John, Trindade, Luisa M., van der Linden, Gerard C., Schwarz, Kai-Uwe, Müller-Sämann, Karl, Anisimov, Alexander, Chen, C.-L., Dolstra, Oene, Donnison, Iain S., Farrar, Kerrie, Fonteyne, Simon, Harding, Graham, Hastings, Astley, Huxley, Laurie M., Iqbal, Yasir, Khokhlov, Nikolay, Kiesel, Andreas, Lootens, Peter, Meyer, Heike, Mos, Michal, Muylle, Hilde, Nunn, Chris, Özgüven, Mensure, Roldán-Ruiz, Isabel, Schüle, Heinrich, Tarakanov, Ivan, van der Weijde, Tim, Wagner, Moritz, Xi, Qingguo, Kalinina, Olena“…A small selection of germplasm types was evaluated for performance in grasslands on marginal sites in Germany and the UK. The growth traits underlying biomass yield and quality were measured to improve regional estimates of feedstock availability. …”
Publicado 2016
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367758por Aveyard, Paul, Lewis, Amanda, Tearne, Sarah, Hood, Kathryn, Christian-Brown, Anna, Adab, Peymane, Begh, Rachna, Jolly, Kate, Daley, Amanda, Farley, Amanda, Lycett, Deborah, Nickless, Alecia, Yu, Ly-Mee, Retat, Lise, Webber, Laura, Pimpin, Laura, Jebb, Susan A“…INTERPRETATION: A behaviourally-informed, very brief, physician-delivered opportunistic intervention is acceptable to patients and an effective way to reduce population mean weight. FUNDING: The UK National Prevention Research Initiative.…”
Publicado 2016
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367759por de Jong, Martie, Korrelboom, Kees, van der Meer, Iris, Deen, Mathijs, Hoek, Hans W., Spinhoven, Philip“…Initial research in the UK suggests that CBT-E is more effective for EDs, especially bulimia nervosa (BN) and EDNOS, than the earlier version of CBT. …”
Publicado 2016
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367760por Gray, Alasdair J., Roobottom, Carl, Smith, Jason E., Goodacre, Steve, Oatey, Katherine, O’Brien, Rachel, Storey, Robert F., Na, Lumine, Lewis, Steff C., Thokala, Praveen, Newby, David E.“…METHODS/DESIGN: Participants will be recruited in about 35 tertiary and district general hospitals in the UK. Patients ≥18 years old with symptoms with suspected/confirmed ACS with at least one of the following will be included: (1) ECG abnormalities, e.g. …”
Publicado 2016
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