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370641por Abend, M., Amundson, S. A., Badie, C., Brzoska, K., Hargitai, R., Kriehuber, R., Schüle, S., Kis, E., Ghandhi, S. A., Lumniczky, K., Morton, S. R., O’Brien, G., Oskamp, D., Ostheim, P., Siebenwirth, C., Shuryak, I., Szatmári, T., Unverricht-Yeboah, M., Ainsbury, E., Bassinet, C., Kulka, U., Oestreicher, U., Ristic, Y., Trompier, F., Wojcik, A., Waldner, L., Port, M.Enlace del recurso
Publicado 2021
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370642por Zhu, Na, Swietlik, Emilia M., Welch, Carrie L., Pauciulo, Michael W., Hagen, Jacob J., Zhou, Xueya, Guo, Yicheng, Karten, Johannes, Pandya, Divya, Tilly, Tobias, Lutz, Katie A., Martin, Jennifer M., Treacy, Carmen M., Rosenzweig, Erika B., Krishnan, Usha, Coleman, Anna W., Gonzaga-Juaregui, Claudia, Lawrie, Allan, Trembath, Richard C., Wilkins, Martin R., Morrell, Nicholas W., Shen, Yufeng, Gräf, Stefan, Nichols, William C., Chung, Wendy K.“…METHODS: To identify new risk genes, we utilized an international consortium of 4241 PAH cases with exome or genome sequencing data from the National Biological Sample and Data Repository for PAH, Columbia University Irving Medical Center, and the UK NIHR BioResource – Rare Diseases Study. The strength of this combined cohort is a doubling of the number of IPAH cases compared to either national cohort alone. …”
Publicado 2021
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370643por King, Anthony J, Hudson, Jemma, Fernie, Gordon, Kernohan, Ashleigh, Azuara-Blanco, Augusto, Burr, Jennifer, Homer, Tara, Shabaninejad, Hosein, Sparrow, John M, Garway-Heath, David, Barton, Keith, Norrie, John, McDonald, Alison, Vale, Luke, MacLennan, Graeme, King, Anthony, Agrawal, Pavi, Stead, Richard, Broadway, David C, Strouthidis, Nick, Chew, Shenton, Sng, Chelvin, Toth, Marta, Gazzard, Gus, Elkarmouty, Ahmed, Nikita, Eleni, Triolo, Giacinto, Aguilar-Munoa, Soledad, Goyal, Saurabh, Lim, Sheng, Sung, Velota, Masood, Imran, Wride, Nicholas, Sandhu, Amanjeet, Hill, Elizabeth, Sparrow, John, Grey, Fiona, Bourne, Rupert, Nithyanandarajah, Gnanapragasam, Willshire, Catherine, Bloom, Philip, Ahmed, Faisal, Cordeiro, Franesca, Crawley, Laura, Normando, Eduardo, Ameen, Sally, Tryfinopoulou, Joanna, Porteous, Alistair, Jutley, Gurjeet, Bessinis, Dimitrios, Kirwan, James, Begum, Shahiba, Sepetis, Anastasios, Rule, Edward, Thornton, Richard, McNaught, Andrew, Anand, Nitin, Negi, Anil, Kousha, Obaid, Hovan, Marta, Sanders, Roshini, Agarwal, Pankaj Kumar, Tatham, Andrew, Au, Leon, Fenerty, Cecelia, Karaconji, Tanya, Drury, Brett, Penmol, Duya, Ansari, Ejaz, Dardzhikova, Albina, Moosavi, Reza, Imonikhe, Richard, Kontovourikis, Prodromos, Membrey, Luke, Almeida, Goncalo, Tildsley, James, Azuara-Blanco, Augusto, Knox, Angela, Rankin, Simon, Wilson, Sara, Prabhu, Avinash, Mukherji, Subhanjan, Datta, Amit, Fern, Alisdair, Liput, Joanna, Manners, Tim, Pilling, Josh, Stemp, Clare, Martin, Karen, Nixon, Tracey, Cobb, Caroline, Rotchford, Alan, Sidiki, Sikander, Bansal, Atul, Kousha, Obaid, Auger, Graham, Freeman, Mary“…SETTING: 27 secondary care glaucoma departments in the UK. PARTICIPANTS: 453 adults presenting with newly diagnosed advanced open angle glaucoma in at least one eye (Hodapp classification) between 3 June 2014 and 31 May 2017. …”
Publicado 2021
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370644por Gissen, Paul, Specchio, Nicola, Olaye, Andrew, Jain, Mohit, Butt, Thomas, Ghosh, Wrik, Ruban-Fell, Benjamin, Griffiths, Annabel, Camp, Charlotte, Sisic, Zlatko, Schwering, Christoph, Wibbeler, Eva, Trivisano, Marina, Lee, Laura, Nickel, Miriam, Mortensen, Amanda, Schulz, Angela“…Resulting scores were converted to EQ-5D-5L utility values for each disease stage, using UK, German and Spanish value sets. RESULTS: Utility values, which are typically anchored by 0 (equivalent to death) and 1 (full health), decreased with CLN2 disease progression (results spanned the maximum range of the utility scale). …”
Publicado 2021
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370645por Gago-Dominguez, Manuela, Redondo, Carmen M., Calaza, Manuel, Matabuena, Marcos, Bermudez, Maria A., Perez-Fernandez, Roman, Torres-Español, María, Carracedo, Ángel, Castelao, J. EstebanEnlace del recurso
Publicado 2021
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370646por Ikeda, Satoshi, Misumi, Toshihiro, Izumi, Shinyu, Sakamoto, Keita, Nishimura, Naoki, Ro, Shosei, Fukunaga, Koichi, Okamori, Satoshi, Tachikawa, Natsuo, Miyata, Nobuyuki, Shinkai, Masaharu, Shinoda, Masahiro, Miyazaki, Yasunari, Iijima, Yuki, Izumo, Takehiro, Inomata, Minoru, Okamoto, Masaki, Yamaguchi, Tomoyoshi, Iwabuchi, Keisuke, Masuda, Makoto, Takoi, Hiroyuki, Oyamada, Yoshitaka, Fujitani, Shigeki, Mineshita, Masamichi, Ishii, Haruyuki, Nakagawa, Atsushi, Yamaguchi, Nobuhiro, Hibino, Makoto, Tsushima, Kenji, Nagai, Tatsuya, Ishikawa, Satoru, Ishikawa, Nobuhisa, Kondoh, Yasuhiro, Yamazaki, Yoshitaka, Gocho, Kyoko, Nishizawa, Tomotaka, Tsuzuku, Akifumi, Yagi, Kazuma, Shindo, Yuichiro, Takeda, Yuriko, Yamanaka, Takeharu, Ogura, TakashiEnlace del recurso
Publicado 2021
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370647por Belay, Mulugeta, Tulu, Begna, Younis, Sidra, Jolliffe, David A, Tayachew, Dawit, Manwandu, Hana, Abozen, Tenagnework, Tirfie, Emawayish A, Tegegn, Metasebia, Zewude, Aboma, Forrest, Sally, Mayito, Jonathan, Huggett, Jim F, Jones, Gerwyn M, O'Sullivan, Denise M, Martineau, Henny M, Noursadeghi, Mahdad, Chandran, Aneesh, Harris, Kathryn A, Nikolayevskyy, Vlad, Demaret, Julie, Berg, Stefan, Vordermeier, Martin, Balcha, Taye T, Aseffa, Abraham, Ameni, Gobena, Abebe, Markos, Reece, Stephen T, Martineau, Adrian R“…Detection of M tuberculosis complex DNA in PBMCs has potential applications in the diagnosis of latent tuberculosis infection, in monitoring response to preventive therapy, and as an outcome measure in clinical trials of interventions to prevent or treat latent tuberculosis infection. FUNDING: UK Medical Research Council.…”
Publicado 2021
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370648“…RESULTS: Overall, 641 patients were enrolled at 78 study centres across 7 countries (Germany, UK, Italy, Spain, Norway, Sweden, and Russia), 633 received ≥1 onabotulinumtoxinA dose, and 128 completed the 2-year study. …”
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370649
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370650
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370651por Bourgeois, Florence T., Gutiérrez-Sacristán, Alba, Keller, Mark S., Liu, Molei, Hong, Chuan, Bonzel, Clara-Lea, Tan, Amelia L. M., Aronow, Bruce J., Boeker, Martin, Booth, John, Cruz Rojo, Jaime, Devkota, Batsal, García Barrio, Noelia, Gehlenborg, Nils, Geva, Alon, Hanauer, David A., Hutch, Meghan R., Issitt, Richard W., Klann, Jeffrey G., Luo, Yuan, Mandl, Kenneth D., Mao, Chengsheng, Moal, Bertrand, Moshal, Karyn L., Murphy, Shawn N., Neuraz, Antoine, Ngiam, Kee Yuan, Omenn, Gilbert S, Patel, Lav P., Jiménez, Miguel Pedrera, Sebire, Neil J., Balazote, Pablo Serrano, Serret-Larmande, Arnaud, South, Andrew M., Spiridou, Anastasia, Taylor, Deanne M., Tippmann, Patric, Visweswaran, Shyam, Weber, Griffin M., Kohane, Isaac S., Cai, Tianxi, Avillach, Paul“…Patient-level electronic health record (EHR) data were collected across 27 hospitals in France, Germany, Spain, Singapore, the UK, and the US. Patients younger than 21 years who tested positive for COVID-19 and were hospitalized at an institution participating in the Consortium for Clinical Characterization of COVID-19 by EHR were included in the study. …”
Publicado 2021
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370652por Zhang, Xia, Wei, Mengping, Fan, Jiahui, Yan, Weijie, Zha, Xu, Song, Huimeng, Wan, Rongqi, Yin, Yanling, Wang, WeiEnlace del recurso
Publicado 2020
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370653por Ponsford, Amy H., Ryan, Thomas A., Raimondi, Andrea, Cocucci, Emanuele, Wycislo, Susanne A., Fröhlich, Florian, Swan, Laura E., Stagi, MassimilianoEnlace del recurso
Publicado 2020
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370654por Metwally, Mostafa, Chatters, Robin, Dimairo, Munya, Walters, Stephen, Pye, Clare, White, David, Bhide, Priya, Chater, Tim, Cheong, Ying, Choudhary, Meenakshi, Child, Tim, Drakeley, Andrew, Evbuomwan, Isaac, Gelbaya, Tarek, Grace, Jan, Harris, Philip, Laird, Susan, da Silva, Sarah Martins, Mohiyiddeen, Lamiya, Pemberton, Kirsty, Raine-Fenning, Nick, Rajkhowa, Madhurima, Young, Tracey, Cohen, Judith“…PARTICIPANTS/MATERIALS, SETTING, METHODS: Participants aged 18–37 years undergoing their first cycle of IVF, with or without ICSI, were recruited from 16 UK fertility clinics and randomised (1:1) by a web-based system with restricted access rights that concealed allocation. …”
Publicado 2021
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370655por Prakash, Ajay, Singh, Harvinder, Sarma, Phulen, Bhattacharyya, Anusuya, Dhibar, Deba Prasad, Balaini, Neeraj, Shree, Ritu, Goyal, Manoj, Modi, Manish, Medhi, BikashEnlace del recurso
Publicado 2021
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370656por Patone, Martina, Thomas, Karen, Hatch, Rob, Tan, Pui San, Coupland, Carol, Liao, Weiqi, Mouncey, Paul, Harrison, David, Rowan, Kathryn, Horby, Peter, Watkinson, Peter, Hippisley-Cox, Julia“…BACKGROUND: A more transmissible variant of SARS-CoV-2, the variant of concern 202012/01 or lineage B.1.1.7, has emerged in the UK. We aimed to estimate the risk of critical care admission, mortality in patients who are critically ill, and overall mortality associated with lineage B.1.1.7 compared with non-B.1.1.7. …”
Publicado 2021
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370657por Lee, Woo-Do, Kothari, Damini, Niu, Kai-Min, Lim, Jeong-Min, Park, Da-Hye, Ko, Jaeeun, Eom, Kidong, Kim, Soo-KiEnlace del recurso
Publicado 2021
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370658“…An updated analysis is merited should UK National Institute for Health Care and Excellence prescribing guidelines for T2DM be revised to incorporate new data on the benefits for those with reduced renal function or with heart failure. …”
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370659por García-Fiñana, Marta, Hughes, David M, Cheyne, Christopher P, Burnside, Girvan, Stockbridge, Mark, Fowler, Tom A, Fowler, Veronica L, Wilcox, Mark H, Semple, Malcolm G, Buchan, Iain“…SETTING: Community LFT pilot at covid-19 testing sites in Liverpool, UK. PARTICIPANTS: 5869 asymptomatic adults (≥18 years) voluntarily attending one of 48 testing sites during 6-29 November 2020. …”
Publicado 2021
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370660por Stock, Sarah J., Horne, Margaret, Bruijn, Merel, White, Helen, Boyd, Kathleen A., Heggie, Robert, Wotherspoon, Lisa, Aucott, Lorna, Morris, Rachel K., Dorling, Jon, Jackson, Lesley, Chandiramani, Manju, David, Anna L., Khalil, Asma, Shennan, Andrew, van Baaren, Gert-Jan, Hodgetts-Morton, Victoria, Lavender, Tina, Schuit, Ewoud, Harper-Clarke, Susan, Mol, Ben W., Riley, Richard D., Norman, Jane E., Norrie, John“…On external validation in the prospective UK cohort population, the area under the curve was 0.89 (95% CI 0.84 to 0.94), and Nagelkerke R(2) of 36% (95% CI: 34% to 38%). …”
Publicado 2021
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