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  1. 370861
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    High-dimensional multinomial multiclass severity scoring of COVID-19 pneumonia using CT radiomics features and machine learning algorithms
  2. 370862
    “…METHODS: In a multicentre, double-blind, randomised, parallel-group, placebo-controlled trial, across 14 hospitals in the UK, patients aged 16 years and older who were hospitalised with COVID-19 and had at least one risk factor for severe disease were randomly assigned 1:1, within 96 h of hospital admission, to once-daily brensocatib 25 mg or placebo orally for 28 days. …”
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    Dipeptidyl peptidase-1 inhibition in patients hospitalised with COVID-19: a multicentre, double-blind, randomised, parallel-group, placebo-controlled trial
  3. 370863
    “…METHODS: We conducted two Cox proportional-hazard GWAS of MSS using data from the Melanoma Institute Australia, a high ultraviolet (UV) radiation setting (MIA; 5,762 patients with melanoma; 800 melanoma deaths) and UK Biobank (UKB: 5,220 patients with melanoma; 241 melanoma deaths), and combined them in a fixed-effects meta-analysis. …”
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    Higher polygenic risk for melanoma is associated with improved survival in a high ultraviolet radiation setting
  4. 370864
    “…BACKGROUND: Approximately 15 million people in the UK live with obesity, around 5 million of whom have severe obesity (body mass index (BMI) ≥35kg/m(2)). …”
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    A group-based behavioural intervention for weight management (PROGROUP) versus usual care in adults with severe obesity: a feasibility randomised controlled trial protocol
  5. 370865
    “…METHODS: This is an open-label, multicentre, randomized phase III trial with two parallel arms. 326 immunocompetent patients with newly diagnosed PCNSL will be recruited from 37 German, 1 Austrian and 12 UK sites. Additional IELSG (International Extranodal Lymphoma Study Group) sites are planned. …”
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    Optimizing MATRix as remission induction in PCNSL: de-escalated induction treatment in newly diagnosed primary CNS lymphoma
  6. 370866
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    Using a concurrent challenge with porcine circovirus 2 and porcine reproductive and respiratory syndrome virus to compare swine vaccination programs
  7. 370867
    por Zhang, Ruyang, Shen, Sipeng, Wei, Yongyue, Zhu, Ying, Li, Yi, Chen, Jiajin, Guan, Jinxing, Pan, Zoucheng, Wang, Yuzhuo, Zhu, Meng, Xie, Junxing, Xiao, Xiangjun, Zhu, Dakai, Li, Yafang, Albanes, Demetrios, Landi, Maria Teresa, Caporaso, Neil E., Lam, Stephen, Tardon, Adonina, Chen, Chu, Bojesen, Stig E., Johansson, Mattias, Risch, Angela, Bickeböller, Heike, Wichmann, H-Erich, Rennert, Gadi, Arnold, Susanne, Brennan, Paul, McKay, James D., Field, John K., Shete, Sanjay S., Le Marchand, Loic, Liu, Geoffrey, Andrew, Angeline S., Kiemeney, Lambertus A., Zienolddiny-Narui, Shan, Behndig, Annelie, Johansson, Mikael, Cox, Angela, Lazarus, Philip, Schabath, Matthew B., Aldrich, Melinda C., Dai, Juncheng, Ma, Hongxia, Zhao, Yang, Hu, Zhibin, Hung, Rayjean J., Amos, Christopher I., Shen, Hongbing, Chen, Feng, Christiani, David C.
    Publicado 2022
    “…METHODS: Leveraging a total of 445,221 European-descent participants from the International Lung Cancer Consortium OncoArray project, Transdisciplinary Research in Cancer of the Lung and UK Biobank, we performed a large-scale genome-wide G × G interaction study on European NSCLC risk by a series of analyses. …”
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    A Large-Scale Genome-Wide Gene-Gene Interaction Study of Lung Cancer Susceptibility in Europeans With a Trans-Ethnic Validation in Asians
  8. 370868
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    Head-to-head comparison of (99m)Tc-PSMA and (99m)Tc-MDP SPECT/CT in diagnosing prostate cancer bone metastasis: a prospective, comparative imaging trial
  9. 370869
    “…The recommendation for third primary dose is based on preliminary results from UK studies of real-world vaccine effectiveness (VE) in persons who are immunosuppressed, suggesting a modest reduction in VE against symptomatic COVID-19. …”
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    P69 COVID vaccine uptake in young persons on immunosuppression under the care of tertiary paediatric rheumatology service
  10. 370870
    por Bohn, Marcela, Petrushkin, Harry
    Publicado 2022
    “…It receives new patients mainly from paediatric uveitis clinics at MEH and Great Ormond Street Hospital (GOSH), both reference centres, but also from multiple other paediatric services across London and the UK. The patients are seen from the age of 16 to 21 (or more in special circumstances). …”
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    P54 Evaluating capacity issues and safety of uveitis adolescent services at Moorfields Eye Hospital (MEH)
  11. 370871
    “…DESCRIPTION/METHOD: A total of 472 JDM patients recruited via UK Juvenile Dermatomyositis Cohort and Biomarker Study (JDCBS) were included in this study. …”
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    OA29 Blotting-based assays under-detected TIF1-gamma and NXP2 autoantibodies compared to immunoprecipitation in Juvenile Dermatomyositis cohorts
  12. 370872
    por Beesley, Richard
    Publicado 2022
    “…Recent analysis in the UK [1] has provided an update to the estimated incidence and prevalence of JIA. …”
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    P64 Accurate incidence and prevalence estimates are important for families of children with juvenile idiopathic arthritis
  13. 370873
    “…SYSTEMATIC REVIEW REGISTRATION: https://www.crd.york.ac.uk/PROSPERO/, identifier CRD42022338308.…”
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    Patients with melanoma treated with immune checkpoint inhibitors who had non-thyroid endocrine and skin immune-related adverse events have better prognosis: A systematic review and meta-analysis
  14. 370874
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    Biomarkers extracted by fully automated body composition analysis from chest CT correlate with SARS-CoV-2 outcome severity
  15. 370875
    “…TRIAL REGISTRATION: International Prospective Register of Systematic Reviews (PROSPERO); CRD42021260910; https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021260910…”
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    Synthesis of the Evidence on What Works for Whom in Telemental Health: Rapid Realist Review
  16. 370876
    por Silva, Clovis A., Medeiros-Ribeiro, Ana C., Kupa, Leonard V. K., Yuki, Emily F. N., Pasoto, Sandra G., Saad, Carla G. S., Fusco, Solange R. G., Pereira, Rosa M. R., Shinjo, Samuel K., Halpern, Ari S. R., Borba, Eduardo F., Souza, Fernando H. C., Guedes, Lissiane K. N., Miossi, Renata, Bonfiglioli, Karina R., Domiciano, Diogo S., Shimabuco, Andrea Y., Andrade, Danieli C. O., Seguro, Luciana P. C., Fuller, Ricardo, Sampaio-Barros, Percival D., Assad, Ana P. L., Moraes, Julio C. B., Goldenstein-Schainberg, Claudia, Giardini, Henrique A. M., Silva, Henrique C., Martins, Victor A. O., Villamarin, Lorena E. B., Novellino, Renata S., Sales, Lucas P., Araújo, Carlo S. R., Silva, Matheus S. R., Filho, Dilson M. N., Lopes, Marta H., Duarte, Alberto J. S., Kallas, Esper G., Aikawa, Nadia E., Bonfa, Eloisa
    Publicado 2022
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    Immunogenicity decay and case incidence six months post Sinovac-CoronaVac vaccine in autoimmune rheumatic diseases patients
  17. 370877
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    The relationship between systemic immune inflammation index and survival in patients with metastatic renal cell carcinomatreated withtyrosine kinase inhibitors
  18. 370878
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    The Africans in America study demonstrates that subclinical cardiovascular risk differs by etiology of abnormal glucose tolerance
  19. 370879
    “…STUDY AIMS: To determine accuracy of the European Society of Cardiology (ESC) and British Society of Echocardiography (BSE) TTE probability algorithm in detecting PH in patients attending a UK PH centre. To identify echocardiographic markers and revised algorithms to improve the detection of PH in those with low/intermediate BSE/ESC TTE PH probability. …”
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    IMproving PULmonary hypertension Screening by Echocardiography: IMPULSE
  20. 370880
    por Fritz, Nikola, Berens, Sabrina, Dong, Yuanjun, Martínez, Cristina, Schmitteckert, Stefanie, Houghton, Lesley A., Goebel-Stengel, Miriam, Wahl, Verena, Kabisch, Maria, Götze, Dorothea, D’Amato, Mauro, Zheng, Tenghao, Röth, Ralph, Mönnikes, Hubert, Tesarz, Jonas, Engel, Felicitas, Gauss, Annika, Raithel, Martin, Andresen, Viola, Keller, Jutta, Frieling, Thomas, Pehl, Christian, Stein-Thöringer, Christoph, Clarke, Gerard, Kennedy, Paul J., Cryan, John F., Dinan, Timothy G., Quigley, Eamonn M. M., Spiller, Robin, Beltrán, Caroll, Madrid, Ana María, Torres, Verónica, Mayer, Emeran A., Sayuk, Gregory, Gazouli, Maria, Karamanolis, George, Bustamante, Mariona, Estivil, Xavier, Rabionet, Raquel, Hoffmann, Per, Nöthen, Markus M., Heilmann-Heimbach, Stefanie, Schmidt, Börge, Franke, André, Lieb, Wolfgang, Herzog, Wolfgang, Boeckxstaens, Guy, Wouters, Mira M., Simrén, Magnus, Rappold, Gudrun A., Vicario, Maria, Santos, Javier, Schaefert, Rainer, Lorenzo-Bermejo, Justo, Niesler, Beate
    Publicado 2022
    “…Therefore, genotype data of 2682 IBS patients and 9650 controls from 14 cohorts (Chile, Germany (2), Greece, Ireland, Spain, Sweden (2), the UK (3), and the USA (3)) were taken into account. …”
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    The serotonin receptor 3E variant is a risk factor for female IBS-D
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