“…Although fungi produce many specialised or secondary metabolites for defence and interacting with the surrounding environment, the repertoire of specialised metabolites (SM) within Pyrenophora pathogenic species remains mostly uncharted. In this study, an in-depth comparative analysis of the P. teres f. teres, P teres f. maculata and P. tritici-repentis potential to produce SMs, based on in silico predicted biosynthetic gene clusters (BGCs), was conducted using genome assemblies from PacBio DNA reads. …”
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“…However, to what extent these processes are mirrored in humans is largely uncharted thus questioning their relevance in human circuit function. …”
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“…Thus, our work demonstrates that APA links genetic variation to variation in gene expression, protein expression, and disease risk, and reveals uncharted modes of genetic regulation.…”
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“…Therefore, it is believed that discovering novel cannabinoids starting from studying the biodiversity of the species living on planet earth is an uncharted territory.…”
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“…Out there, the seas of the pandemic are turbulent and uncharted, and it is impossible to know in advance everything of the other dangers that may lurk beyond those cloudy horizons. …”
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“…However, synthesising whole-body images remains largely uncharted territory involving many challenges, including large image size and limited field of view, complex spatial context, and anatomical differences between images acquired at different times. …”
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“…In particular, discovering the unique interaction features of IDRs originating from their dynamic nature may reveal uncharted regulatory mechanisms of specific biological processes. …”
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“…However, core-level spectroscopy is thus far almost uncharted in GW. We show that single-shot perturbation calculations in the G(0)W(0) approximation, which are routinely used for valence states, cannot be applied for core levels and suffer from an extreme, erroneous transfer of spectral weight to the satellite spectrum. …”
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“…However, the mechanisms behind ABs biogenesis remain uncharted. Using an RNA-sequencing approach, we compared the transcriptional profile of ABs induced by iron starvation to untreated bacteria in the Chlamydia-related species Waddlia chondrophila, a potential agent of abortion in ruminants and miscarriage in humans. …”
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“…Circadian and circannual cycles trigger physiological changes whose reflection on human transcriptomes remains largely uncharted. We used the time and season of death of 932 individuals from GTEx to jointly investigate transcriptomic changes associated with those cycles across multiple tissues. …”
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“…However, the genetics of MMN are uncharted, limiting the validation of MMN as a psychosis endophenotype. …”
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“…This review illustrates how organic synthesis provides access to uncharted areas of membrane glycobiology research and its application to biomedicine. …”
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“…Such rigorous distinction and intermolecular repulsive force-driven aggregation inhibition by cellular macromolecules could give new insights into understanding the complex cellular protein landscapes that remain uncharted.…”
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“…Although it has been in use from the late 19th century, it is an uncharted territory for most developing nations. In this article, we have discussed the pros and cons of convalescent plasma transfusion in COVID-19 patients. …”
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“…Our approach showcases a general strategy to explore uncharted functional space in complex biomolecular regulations.…”
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“…These limited available data encourage one to systematically explore the largely uncharted role of GH in human HF biology to uncover nonclassical functions of this core neurohormone in human skin physiology.…”
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“…Thermodynamic uncertainty principles make up one of the few rare anchors in the largely uncharted waters of nonequilibrium systems, the fluctuation theorems being the more familiar. …”
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“…A direct consequence is a paradigm shift to large volume unenhanced CT scans being utilized for acute and post traumatic patients in EDs, an uncharted territory for most radiologists and trainees. …”
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“…We also provide a perspective on a few uncharted but outstanding questions for future studies. …”
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“…For the past few years, experiments at the Fermilab Tevatron Collider have once again been exploring uncharted territory at the current energy frontier of particle physics. …”
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