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241“…In this day and age of artificial intelligence, machine learning, advanced imaging, and cutting-edge research in the field of neurology, the exact cortical control of vestibular function is still uncharted. A 45-year-old woman with a past medical history of labyrinthitis about 4.5 years ago (resolved) presented to hospital due to severe dizziness, emesis, and mild vertical diplopia for the past few days. …”
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242“…The realm of antimicrobial proteins in plants is extensive but remains relatively uncharted. Understanding the mechanisms underlying the action of plant antifungal proteins (AFPs) holds promise for antifungal strategies. …”
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243“…This exploration, starting with tRNA-derived small RNAs, has led to the discovery of a diverse universe of sncRNAs derived from various longer structured RNAs such as rRNAs, small nucleolar RNAs, small nuclear RNAs, Y RNAs, and vault RNAs, with exciting uncharted functional possibilities. In this perspective, we discuss the emerging functional principles of sncRNAs beyond the well-known RNAi-like mechanisms, focusing on those that operate independent of linear sequence complementarity but rather function in an aptamer-like fashion. …”
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244por Daligault, Hajnalka, Lapidus, Alla, Zeytun, Ahmet, Nolan, Matt, Lucas, Susan, Del Rio, Tijana Glavina, Tice, Hope, Cheng, Jan-Fang, Tapia, Roxanne, Han, Cliff, Goodwin, Lynne, Pitluck, Sam, Liolios, Konstantinos, Pagani, Ioanna, Ivanova, Natalia, Huntemann, Marcel, Mavromatis, Konstantinos, Mikhailova, Natalia, Pati, Amrita, Chen, Amy, Palaniappan, Krishna, Land, Miriam, Hauser, Loren, Brambilla, Evelyne-Marie, Rohde, Manfred, Verbarg, Susanne, Göker, Markus, Bristow, James, Eisen, Jonathan A., Markowitz, Victor, Hugenholtz, Philip, Kyrpides, Nikos C., Klenk, Hans-Peter, Woyke, Tanja“…The species is of interest because of its isolated phylogenetic location in the tree of life, especially the so far genomically uncharted part of it, and because the organism grows in a thin, hardly visible hyaline sheath. …”
Publicado 2011
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245por Mudd, Austin B., White, Elizabeth J., Bolloskis, Michael P., Kapur, Nicholas P., Everhart, Koyt W., Lin, Ying-Chen, Bussler, Weston W., Reid, Robert W., Brown, Ryan H.“…The solid background presented in this paper provides future researchers the foundation to explore these uncharted areas.…”
Publicado 2013
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246por Shvyd’ko, Yuri, Stoupin, Stanislav, Shu, Deming, Collins, Stephen P., Mundboth, Kiran, Sutter, John, Tolkiehn, Martin“…The spectrometer opens up uncharted space on the dynamics landscape. New results are presented on the dynamics of liquid glycerol, in the regime that has become accessible with the novel spectrometer.…”
Publicado 2014
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247“…Although representatives of earlier-branching animals – sponges ctenophores and placozoans – possess most of the developmental transcription factor families present in eumetazoans, the DNA regulatory elements that these transcription factors target remain uncharted. Here we characterise the core promoter sequences, U1 snRNP-binding sites (5′ splice sites; 5′SSs) and polyadenylation sites (PASs) in the sponge Amphimedon queenslandica. …”
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248“…The availability of genomic sequences from uncharted branches of the archaeal tree has highlighted the existence of novel methanogenic lineages phylogenetically distant to previously known ones, such as the Methanomassiliicoccales. …”
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249“…Discussions fell into three broad categories that the authors have termed: trading war stories, measuring up, and navigating uncharted waters. It is likely that physicians have a strong need for peer mentorship in the first few years after the transition from residency, and a journal club or similar discussion group may be one way to fulfil this.…”
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250por Kovaltsuk, Aleksandr, Krawczyk, Konrad, Galson, Jacob D., Kelly, Dominic F., Deane, Charlotte M., Trück, Johannes“…The mapping of Ig-seq datasets to known antibody structures can indicate structurally, and perhaps functionally, uncharted areas. Furthermore, contrasting naïve and antigenically challenged datasets using structural antibody descriptors should provide insights into antibody maturation. …”
Publicado 2017
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251por Serino, Silvia, Scarpina, Federica, Dakanalis, Antonios, Keizer, Anouk, Pedroli, Elisa, Castelnuovo, Gianluca, Chirico, Alice, Catallo, Valentina, di Lernia, Daniele, Riva, Giuseppe“…A growing body of evidence demonstrated that it is feasible to induce ownership over an artificial body to alter bodily experience. However, several uncharted aspects about full-body illusion applications need to be tackled before a complete exploitation of these methods in clinical practice. …”
Publicado 2018
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252“…To demonstrate this, we examine the uncharted terrain which everyday cyborgs pose for the law, looking in particular at five areas: (i) medical device regulation, safety, and product liability; (ii) damage to devices and liability; (iii) data and privacy; (iv) security and biohacking; and (v) intellectual property rights. …”
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253“…These findings highlight the challenges that exist in SemiSWEETs and provide future researchers the foundation to explore these uncharted areas.…”
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254por Ejegod, Ditte Møller, Pedersen, Helle, Alzua, Garazi Peña, Pedersen, Camilla, Bonde, Jesper“…The use of a dry brush is largely uncharted territory in terms of analytical stability. …”
Publicado 2018
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255por Natoli, Riccardo, Mason, Elizabeth, Jiao, Haihan, Chuah, Aaron, Patel, Hardip, Fernando, Nilisha, Valter, Krisztina, Wells, Christine A., Provis, Jan, Rutar, Matt“…This revealed a previously uncharted interplay of adaptive immunity during subretinal inflammation, including prolonged enrichment of myeloid and lymphocyte migration, antigen presentation, and the alternative arm of the complement cascade involving Factor B. …”
Publicado 2018
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256“…The increasing use of valve-in-valve procedures is expected to bring on further uncharted challenges.…”
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257“…This points towards a widespread yet uncharted capacity of octocoral-associated bacteria to synthetize a broad range of natural products. …”
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258por Shi-Kunne, Xiaoqian, Jové, Roger de Pedro, Depotter, Jasper R L, Ebert, Malaika K, Seidl, Michael F, Thomma, Bart P H J“…However, the SM repertoire of this vascular pathogen remains mostly uncharted. To unravel the potential of V. dahliae to produce SMs, we performed in silico predictions and in-depth analyses of its secondary metabolite clusters. …”
Publicado 2019
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259por Pezzotti, Giuseppe, Adachi, Tetsuya, Boschetto, Francesco, Zhu, Wenliang, Zanocco, Matteo, Marin, Elia, Bal, B. Sonny, McEntire, Bryan J.“…Phenomenological studies of retrievals have clarified the final effect of bone formation, but have left the chemical interactions at the cell–material interface uncharted. Accordingly, the knowledge of the intrinsic material properties relevant for osteoblastogenesis and osteoinduction remains incomplete. …”
Publicado 2019
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260por Nagy, Tamás, Fisi, Viktória, Frank, Dorottya, Kátai, Emese, Nagy, Zsófia, Miseta, Attila“…Although metabolic challenges have long been recognized to influence cell proliferation, the direct impact of diabetes on cell cycle regulatory elements is a relatively uncharted territory. Among other “nutrient sensing” mechanisms, protein O-linked β-N-acetylglucosamine (O-GlcNAc) modification emerged in recent years as a major contributor to the deleterious effects of hyperglycemia. …”
Publicado 2019
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