Mostrando 281 - 300 Resultados de 621 Para Buscar '"Uncharted"', tiempo de consulta: 0.20s Limitar resultados
  1. 281
    por Gairola, V.
    Publicado 2021
    “…The impact of physical isolation has been documented, but mental isolation remains an uncharted space. The psychological trace—the paleontological psychic trauma of experiencing a pandemic as a witnessing subject is not much talked about. …”
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    COVID-19 turned upside down: A psychological perspective
  2. 282
    “…Nevertheless, the impact of TF dynamics on reprogramming efficiency remains uncharted. Here, we identify the successful reprogramming trajectories of the core pluripotency TF, OCT4, and design a genetic controller that enforces such trajectories with high precision. …”
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    Synthetic genetic circuits to uncover and enforce the OCT4 trajectories of successful reprogramming of human fibroblasts
  3. 283
    “…Nevertheless, the exact molecular mechanisms through which the cell writes and, downstream, MT-interacting proteins decipher the tubulin code are still largely uncharted. The purpose of this review is to describe the molecular determinants and the readout mechanisms of the tubulin code, and briefly elucidate how they coordinate MT behavior during critical neuronal events, such as neuron migration, maturation and axonal transport.…”
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    Deciphering the Tubulin Language: Molecular Determinants and Readout Mechanisms of the Tubulin Code in Neurons
  4. 284
    “…Circadian and circannual cycles trigger physiological changes whose reflection on human transcriptomes remains largely uncharted. We used the time and season of death of 932 individuals from GTEx to jointly investigate transcriptomic changes associated with those cycles across multiple tissues. …”
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    Day-night and seasonal variation of human gene expression across tissues
  5. 285
    “…A broad spectrum of new opportunities, in a vast domain of uncharted fundamental and applied physics territories, could be opened by the Gamma Factory research programme.…”
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    The CERN Gamma Factory Initiative: An Ultra-High Intensity Gamma Source
  6. 286
    “…This review aims toward delineating the current knowledge, which is mainly focused on immunomodulatory therapies of the relapsing–remitting form, while shedding light on uncharted approaches of astrocyte-specific therapies that could constitute novel, innovative applications once the role of specific subgroups in disease pathogenesis is clarified.…”
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    The Diversity of Astrocyte Activation during Multiple Sclerosis: Potential Cellular Targets for Novel Disease Modifying Therapeutics
  7. 287
    “…Overall, we showcase how ligand lability grants access to the uncharted chemistry of anti-van’t Hoff–Le Bel germanium(IV) and line up this element as a member in the emerging class of structurally constrained p-block elements.…”
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    Calix[4]pyrrolato-germane-(thf)(2): Unlocking the Anti-van’t Hoff–Le Bel Reactivity of Germanium(IV) by Ligand Dissociation
  8. 288
    “…Mechanisms behind DA losses in aging are however largely uncharted. Past research documented an association between dopaminergic integrity and cerebrovascular health (via white matter lesion volumes). …”
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    Cerebrovascular integrity affects gradients of aging-related dopamine D1 differences in the striatum
  9. 289
    “…The role of regulated cell death in organ development, particularly the impact of non-apoptotic cell death, remains largely uncharted. Ferroptosis, a non-apoptotic cell death pathway known for its iron dependence and lethal lipid peroxidation, is currently being rigorously investigated for its pathological functions. …”
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    Overburdened ferroptotic stress impairs tooth morphogenesis
  10. 290
    “…This challenge is hitherto uncharted territory for medical schools and there is scant guidance for medical educators. …”
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    Conducting a high-stakes OSCE in a COVID-19 environment
  11. 291
    por Madison, Guy
    Publicado 2009
    “…The scope of this flexibility remains largely uncharted, and the underlying mechanisms are a matter for speculation. …”
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    An Auditory Illusion of Infinite Tempo Change Based on Multiple Temporal Levels
  12. 292
    “…The line between the formal and informal sectors may be blurred and movement between them uncharted. We quantified the use of private and public providers of maternity care in low-income areas of Mumbai, India. …”
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    Tracing pathways from antenatal to delivery care for women in Mumbai, India: cross-sectional study of maternity in low-income areas
  13. 293
    “…PrrC homologs are present in many bacterial proteomes, though their biological activities are uncharted. PrrCs consist of two domains: an N-terminal NTPase module related to the ABC family and a distinctive C-terminal ribonuclease module. …”
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    Determinants of eukaryal cell killing by the bacterial ribotoxin PrrC
  14. 294
    “…The remaining 97% is largely uncharted territory, with only a small fraction characterized. …”
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    Pervasive Transcription of the Human Genome Produces Thousands of Previously Unidentified Long Intergenic Noncoding RNAs
  15. 295
    “…Archaea, so far a rather uncharted domain, possess 38 well-supported RBF candidates of which some are known to form functional sub-complexes in yeast. …”
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    The evolution of the ribosome biogenesis pathway from a yeast perspective
  16. 296
    “…This work settles a fundamental requirement for Airy beam applications of optical manipulations, biology science and even some uncharted territories.…”
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    Polarization-controllable Airy beams generated via a photoaligned director-variant liquid crystal mask
  17. 297
    “…As genome-wide transcription is organized under the high-order chromosome structure, it is largely uncharted how circadian gene expression is influenced by chromosome architecture. …”
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    Long-Range Chromosome Interactions Mediated by Cohesin Shape Circadian Gene Expression
  18. 298
    “…Like other obligate intracellular bacteria, the Chlamydiae feature a compact regulatory genome that remains uncharted owing to poor genetic tractability. Exploiting the reduced number of transcription factors (TFs) encoded in the chlamydial (pan-)genome as a model for TF control supporting the intracellular lifestyle, we determined the conserved landscape of TF specificities by ChIP-Seq (chromatin immunoprecipitation-sequencing) in the chlamydial pathogen Waddlia chondrophila. …”
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    Regulatory (pan-)genome of an obligate intracellular pathogen in the PVC superphylum
  19. 299
    “…The vast majority of interactions are uncharted, constituting a major missing link in understanding genome control. …”
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    Lineage-Specific Genome Architecture Links Enhancers and Non-coding Disease Variants to Target Gene Promoters
  20. 300
    por Hernandez-Vargas, Esteban A.
    Publicado 2017
    “…This review aims to discuss briefly the most recent mathematical modeling contributions, harnessing our knowledge toward the uncharted territory of HIV eradication. In addition, problems associated with current models are discussed, in particular, mathematical models consider only T cell responses but HIV control may also depend on other cell responses as well as chemokines and cytokines dynamics.…”
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    Modeling Kick-Kill Strategies toward HIV Cure
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