“…Our strategy opens an uncharted route to discover inducible synthetic regulatory elements from biologically-inspired nucleic acid sequences.…”
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“…This study aimed to investigate the clinical implications of RhoJ, which is an uncharted member of Rho family. RhoJ expression in human GC cell lines and surgical specimens from GC patients were analyzed. …”
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“…In situ fabricated nucleic acids microarrays are versatile and very high-throughput platforms for aptamer optimization and discovery, but the chemical space that can be probed against a given target has largely been confined to DNA, while RNA and non-natural nucleic acid microarrays are still an essentially uncharted territory. 2΄-Fluoroarabinonucleic acid (2΄F-ANA) is a prime candidate for such use in microarrays. …”
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“…The role of rare variants in complex traits remains uncharted. Here, we conduct deep whole genome sequencing of 1457 individuals from an isolated population, and test for rare variant burdens across six cardiometabolic traits. …”
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“…These arenas represent largely uncharted scientific terrain and provide excellent opportunities for both new and experienced researchers. …”
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“…Preliminary evidence indicates that monocots store high levels of free nucleotides and nucleosides but their potential as a source of internal organic nitrogen for use and remobilization is uncharted. Early tillering wheat plants were therefore starved of N over a 5-day time-course with examination of nucleic acid yields in whole shoots, young and old leaves and roots. …”
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“…Long noncoding RNA (lncRNA) represent an uncharted region of the transcriptome. Several lncRNA have been recently described to mediate oncogenic functions, suggesting that these molecules can be potential therapeutic targets. …”
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“…However, the fates of these communities after coalescence remain uncharted. Thus, to explore the effects of microbiota coalescence, we performed reciprocal inoculation and incubation experiments in microcosms using two distinct soils. …”
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“…However, the properties, reactivity, and fate of the 1,8-DHN phenoxyl radical have remained so far uncharted. Herein, we report an integrated experimental and computational characterization of the early intermediates and dimer products that arise by the oxidation of 1,8-DHN. …”
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“…DISCUSSION: The field of surgical referrals is still an uncharted territory and the limited empirical evidence available is of low quality. …”
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“…Applying deep learning methods in materials science research is an important way of solving the time-consuming problems of typical ab initio quantum chemistry methodology, but due to the size of large molecules, large and uncharted fields still exist. Implementing symmetry information can significantly reduce the calculation complexity of structures, as they can be simplified to the minimum symmetric units. …”
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“…The use of environmental DNA (eDNA) potentially facilitates these efforts, albeit quantitative examinations of spawning migrations remain so far mostly uncharted. Here, we investigated spawning migrations of Danube bleak, Alburnus mento, and Vimba bream, Vimba vimba, and found a strong correlation between daily visual fish counts and downstream eDNA signals obtained from filtered water samples analysed with digital PCR and end-point PCR coupled with capillary electrophoresis. …”
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“…DHI development is often a complex and vastly uncharted territory. By exploring the steps we took from concept to clinical testing with the first cardiology CareKit app, we hope to provide useful insights to teams that are starting out on their path to digital health innovation. …”
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“…This study opens up fields of machine learning analysis for discovering uncharted knowledge.…”
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“…This area, however, remains largely uncharted due to the number of experimental challenges. …”
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“…Wilke, but, due to lack of sophisticated experimental techniques it was left uncharted. Until recently, when Heimburg-Jackson, Hady-Machta and Rvachev, independently proposed Soliton Theory (thermodynamic interpretation of nerve membrane), Mechanical Surface Waves theory (electro-mechanical interpretation) and Rvachev Model (mechano-electrical activation of voltage gated sodium ion channels) respectively; encouraging a deviation from the traditional HH interpretation with justification for the physical changes in the nerve membrane observed experimentally. …”
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“…Secondly, we bring new insights into this old, yet uncharted IS family, by exploring its registered elements, as well as the genomic and proteomic databases of bacterial and archaeal strains. …”
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“…In contrast, emerging artificial non-equilibrium self-assembling systems have remained relatively simplistic concerning hierarchical design, and non-equilibrium multi-component systems are uncharted territory. Here we report a modular DNA toolbox allowing to program transient non-equilibrium multicomponent systems across hierarchical length scales by introducing chemically fueled molecular recognition orchestrated by reaction networks of concurrent ATP-powered ligation and cleavage of freely programmable DNA building blocks. …”
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“…Deep sequencing technologies have revealed the once uncharted non-coding transcriptome of circular RNAs (circRNAs). …”
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“…The evolutionary progression from primary to metastatic prostate cancer is largely uncharted, and the implications for liquid biopsy are unexplored. …”
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