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501por Ozyigit, Ahmet“…BACKGROUND: Covid-19 pandemic is an uncharted territory for the world's population. Countries are seeing measures they would have never considered under democratic governance in an attempt to contain case numbers. …”
Publicado 2020
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502por Shi, Xiao-Bin, Yan, Shuo, Zhang, Chi, Zheng, Li-Min, Zhang, Zhan-Hong, Sun, Shu-E, Gao, Yang, Tan, Xin-Qiu, Zhang, De-Yong, Zhou, Xu-Guo“…Here, we used a multi-factorial system containing a non-persistent plant virus, cucumber mosaic virus (CMV), its primary vector, green peach aphid, Myzus persicae, and the obligate endosymbiont, Buchnera aphidicola to explore this uncharted territory. RESULTS: Based on our preliminary research, we hypothesized that aphid endosymbiont B. aphidicola can facilitate CMV transmission by modulating plant volatile profiles. …”
Publicado 2021
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503por Chatzidavid, Sevastianos, Giannakopoulou, Nefeli, Diamantopoulos, Panagiotis Theodorou, Gavriilaki, Eleni, Katsiampoura, Panagiota, Lakiotaki, Eleftheria, Sakellariou, Stratigoula, Viniou, Nora-Athina, Dryllis, Georgios“…CONCLUSIONS: This case raises questions over uncharted aspects of the PNH etiopathogenesis and its potential association with myeloproliferative neoplasms (MPN) and highlights the difficulty of diagnosing and managing patients with more than one potentially thrombophilic conditions, especially with established and severe thromboses.…”
Publicado 2021
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504por Ungerer, Vida, Bronkhorst, Abel J., Van den Ackerveken, Priscilla, Herzog, Marielle, Holdenrieder, Stefan“…While good progress has been made on this front, much of cfDNA biology remains uncharted. Here, we correlated serial measurements of cfDNA size, concentration and nucleosome histone modifications with various cellular parameters, including cell growth rate, viability, apoptosis, necrosis, and cell cycle phase in three different cell lines. …”
Publicado 2021
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505por Santos, Walter Souza, Gurgel-Gonçalves, Rodrigo, Garcez, Lourdes Maria, Abad-Franch, Fernando“…Despite this possible link between deforestation and CD risk, the population-level responses of Amazonian Attalea and their resident Rhodnius to anthropogenic landscape disturbance remain largely uncharted. We studied adult Attalea palms in old-growth forest (OGF), young secondary forest (YSF), and cattle pasture (CP) in two localities of eastern Amazonia. …”
Publicado 2021
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506por Robinne, François‐Nicolas, Hallema, Dennis W., Bladon, Kevin D., Flannigan, Mike D., Boisramé, Gabrielle, Bréthaut, Christian M., Doerr, Stefan H., Di Baldassarre, Giuliano, Gallagher, Louise A., Hohner, Amanda K., Khan, Stuart J., Kinoshita, Alicia M., Mordecai, Rua, Nunes, João Pedro, Nyman, Petter, Santín, Cristina, Sheridan, Gary, Stoof, Cathelijne R., Thompson, Matthew P., Waddington, James M., Wei, Yu“…This is a new reality that societies will have to live with as uncharted fire activity, water crises, and widespread human footprint collide all‐around of the world. …”
Publicado 2021
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507por Coskun, Devrim, Deshmukh, Rupesh, Shivaraj, S. M., Isenring, Paul, Bélanger, Richard R.“…We demonstrate that the structure–function relationship of Lsi2 is largely uncharted and that the standing transport model requires much better supportive evidence. …”
Publicado 2021
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508por Rapti, Georgia“…Mapping cell type and state heterogeneity uncovers uncharted terrains in neurons and especially in glial cell biology, that remains understudied in many aspects. …”
Publicado 2022
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509por Sarkkinen, Joona, Dunkel, Johannes, Tuulasvaara, Anni, Huuskonen, Antti, Atula, Sari, Kekäläinen, Eliisa, Laakso, Sini M.“…The ability of thymic histopathology to predict the long-term impact of thymectomy in non-thymomatous myasthenia gravis (NTMG) is mainly uncharted. We applied digital pathology to quantitatively characterize differences of thymic histology between early-onset (EOMG) and late-onset MG (LOMG) and to investigate the role of thymic changes for thymectomy outcomes in MG. …”
Publicado 2022
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510por Hua, Lingyue, Chen, Wei, Meng, Yan, Qin, Meng, Yan, Zhiqiang, Yang, Rui, Liu, Qiang, Wei, Yuan, Zhao, Yangyu, Yan, Liying, Qiao, Jie“…Specific acquired characteristics of parents can be passed on to descendants through certain molecular mechanisms, yet the underlying connection between AMA‐related alterations in parents and that in offspring remains largely uncharted. METHODS: We profiled the DNA methylomes of paired parental peripheral bloods and cord bloods from 20 nuclear families, including 10 AMA and 10 Young, and additional transcriptomes of 10 paired maternal peripheral bloods and cord bloods. …”
Publicado 2022
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511“…On the other hand, reinforcement learning (RL) is a powerful yet relatively uncharted method in spatiotemporally extended systems. …”
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512“…To do so, we examine the case of blockchain as one of the emerging innovative work-streams in development practices that could lead the way forward and pave the path for new developmental narratives as we all navigate the uncharted territories of the new digital age. This paper provides useful insights about the underlying dynamics underpinning the adoption of blockchain backed-solutions for sustainable development, and it showcases some of the promising use-cases being developed through trial-and-error experiments by its early adopters. …”
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513por Spoerl, Steffen, Erber, Ramona, Gerken, Michael, Taxis, Juergen, Ludwig, Nils, Nieberle, Felix, Biermann, Niklas, Geppert, Carol Immanuel, Ettl, Tobias, Hartmann, Arndt, Beckhove, Philipp, Reichert, Torsten E., Spanier, Gerrit, Spoerl, Silvia“…In oral squamous cell carcinoma (OSCC) however, the characterization of A20 is uncharted territory. We analyzed a tissue microarray (TMA) of 229 surgically-treated OSCC patients (2003–2013). …”
Publicado 2023
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514por Rizos, Iris, Debeljak, Pavla, Finet, Thomas, Klein, Dylan, Ayata, Sakina-Dorothée, Not, Fabrice, Bittner, Lucie“…The exploration of this uncharted protist diversity in oceanic communities relies essentially on studying genetic markers from the environment as taxonomic barcodes. …”
Publicado 2023
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515por Gurtner, Alessandra, Borrelli, Costanza, Gonzalez-Perez, Ignacio, Bach, Karsten, Acar, Ilhan E., Núñez, Nicolás G., Crepaz, Daniel, Handler, Kristina, Vu, Vivian P., Lafzi, Atefeh, Stirm, Kristin, Raju, Deeksha, Gschwend, Julia, Basler, Konrad, Schneider, Christoph, Slack, Emma, Valenta, Tomas, Becher, Burkhard, Krebs, Philippe, Moor, Andreas E., Arnold, Isabelle C.“…Eosinophils—elusive granulocytes that are implicated in a plethora of human pathologies(1–5)—are among these uncharted cell types. The heterogeneity of eosinophils and the gene programs that underpin their pleiotropic functions remain poorly understood. …”
Publicado 2022
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516por Shah, Shiraz A., Deng, Ling, Thorsen, Jonathan, Pedersen, Anders G., Dion, Moïra B., Castro-Mejía, Josué L., Silins, Ronalds, Romme, Fie O., Sausset, Romain, Jessen, Leon E., Ndela, Eric Olo, Hjelmsø, Mathis, Rasmussen, Morten A., Redgwell, Tamsin A., Leal Rodríguez, Cristina, Vestergaard, Gisle, Zhang, Yichang, Chawes, Bo, Bønnelykke, Klaus, Sørensen, Søren J., Bisgaard, Hans, Enault, Francois, Stokholm, Jakob, Moineau, Sylvain, Petit, Marie-Agnès, Nielsen, Dennis S.“…Viral metagenomes (viromes) are difficult to analyse because they span uncharted viral diversity, lacking marker genes and standardized detection methods. …”
Publicado 2023
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517por Kao, Hung-Ying, Pai, Chun-Peng, Wang, Han, Agarwal, Neel, Adams, Joshua, Liu, Zhenghao, Seachrist, Darcie, Keri, Ruth, Schiemann, William“…The alternative splicing of PML precursor mRNA gives rise to various PML isoforms, yet their expression profile in breast cancer cells remains uncharted. We discovered that PML1 is the most abundant isoform in all breast cancer subtypes, and its expression is associated with unfavorable prognosis in estrogen receptor-positive (ER+) breast cancers. …”
Publicado 2023
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518por Li, Haiyan, Jia, Xiaoni, Wang, Yu, Lv, Yali, Wang, Jing, Zhai, Yuyao, Xue, Xiaorong“…CONCLUSION: Monitoring continuously differences in the severity and mortality risk factors for COVID-19 patients between different stages of the pandemic could provide evidence for exploring uncharted territory in the coming post-pandemic era.…”
Publicado 2023
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519por Feng, Kai-chao, Guo, Ye-lei, Liu, Yang, Dai, Han-ren, Wang, Yao, Lv, Hai-yan, Huang, Jian-hua, Yang, Qing-ming, Han, Wei-dong“…However, the potential of CART therapy in treating advanced unresectable/metastatic CCA is uncharted so far. CASE PRESENTATION: In this case, a 52-year-old female who was diagnosed as advanced unresectable/metastatic CCA and resistant to the following chemotherapy and radiotherapy was treated with CART cocktail immunotherapy, which was composed of successive infusions of CART cells targeting epidermal growth factor receptor (EGFR) and CD133, respectively. …”
Publicado 2017
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520por Nithichanon, Arnone, Rinchai, Darawan, Buddhisa, Surachat, Saenmuang, Pornpun, Kewcharoenwong, Chidchamai, Kessler, Bianca, Khaenam, Prasong, Chetchotisakd, Ploenchan, Maillere, Bernard, Robinson, John, Reynolds, Catherine J., Boyton, Rosemary J., Altmann, Daniel M., Lertmemongkolchai, Ganjana“…The nature of immune correlates dictating why most exposed individuals in endemic regions undergo asymptomatic seroconversion while others succumb to life-threatening sepsis is largely uncharted. Bp seroreactive, immunogenic proteins have previously been identified by antigen microarray. …”
Publicado 2018
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