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521por Zhang, Yuru, Qin, Chaobin, Yang, Liping, Lu, Ronghua, Zhao, Xiaoyan, Nie, Guoxing“…Why basal glycaemia is different between fish and mammals and how carbohydrate metabolism is different amongst organisms is largely uncharted territory. The utilization of comparative systems biology with model vertebrates to explore fish metabolism has become an essential approach to unravelling hidden in vivo mechanisms. …”
Publicado 2018
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522por Pyzik, Adam, Ciezkowska, Martyna, Krawczyk, Pawel S., Sobczak, Adam, Drewniak, Lukasz, Dziembowski, Andrzej, Lipinski, Leszek“…BACKGROUND: Although interactions between microorganisms involved in biogas production are largely uncharted, it is commonly accepted that methanogenic Archaea are essential for the process. …”
Publicado 2018
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523“…In this work we present the elucidation of this hitherto uncharted pathway. In order to confirm our predictions regarding genes coding for arabitol utilization, we performed differential gene expression analysis of B. methanolicus MGA3 cells grown on arabitol as compared to mannitol via transcriptome sequencing (RNA-seq). …”
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524“…While the initial approach to biosimilars was understandably cautious and conservative in that uncharted territory to protect patients’ safety, the analytical and scientific progress and accumulated experience with biosimilars continues to reshape regulatory requirements, generally leading to a reduced burden of clinical trials. …”
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525“…It has been described as “uncharted territories’’ due to a lack of data, resources and records. …”
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526por Gavriilidou, Asimenia, Gutleben, Johanna, Versluis, Dennis, Forgiarini, Francesca, van Passel, Mark W. J., Ingham, Colin J., Smidt, Hauke, Sipkema, Detmer“…CONCLUSIONS: Our study elucidates the functional repertoire of marine Flavobacteriaceae and highlights the need to combine genomic and experimental data while using the appropriate stimuli to unlock their uncharted metabolic potential.…”
Publicado 2020
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527“…These may be associated with the uncharted nature of this disease process.It is impossible to disassociate the necessary therapeutic-intensity anticoagulation with the observed heightened frequency of life-ending intracranial haemorrhage in these patients.…”
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528“…Overall, we present four novel, and lipophilic, scaffolds obtained from an exhaustive search of diverse and uncharted regions of chemical space, which may be further explored in vitro through structure-activity relationship (SAR) studies in the search for more potent inhibitors. …”
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529por Tripathi, Avantika, Kashyap, Anjali, Tripathi, Greesham, Yadav, Joni, Bibban, Rakhi, Aggarwal, Nikita, Thakur, Kulbhushan, Chhokar, Arun, Jadli, Mohit, Sah, Ashok Kumar, Verma, Yeshvandra, Zayed, Hatem, Husain, Amjad, Bharti, Alok Chandra, Kashyap, Manoj Kumar“…This review summarizes tumor reversion developments, present issues, and unaddressed challenges that remained in the uncharted territory to modulate cellular machinery for tumor reversion towards therapeutic purposes successfully. …”
Publicado 2021
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530por Ashok, Cheemala, Ahuja, Neha, Natua, Subhashis, Mishra, Jharna, Samaiya, Atul, Shukla, Sanjeev“…Although a considerable body of research sought to understand the EMT-associated ESRP1 downregulation, the regulatory mechanisms underlying ESRP1 upregulation in primary tumors remained largely uncharted. This study seeks to unveil the regulatory mechanisms that spatiotemporally fine-tune the ESRP1 expression during breast carcinogenesis. …”
Publicado 2021
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531por Sedda, Manuel Arca, Berry, Christopher P. L., Jani, Karan, Amaro-Seoane, Pau, Auclair, Pierre, Baird, Jonathon, Baker, Tessa, Berti, Emanuele, Breivik, Katelyn, Caprini, Chiara, Chen, Xian, Doneva, Daniela, Ezquiaga, Jose M., Ford, K. E. Saavik, Katz, Michael L., Kolkowitz, Shimon, McKernan, Barry, Mueller, Guido, Nardini, Germano, Pikovski, Igor, Rajendran, Surjeet, Sesana, Alberto, Shao, Lijing, Tamanini, Nicola, Warburton, Niels, Witek, Helvi, Wong, Kaze, Zevin, Michael“…Between the [Formula: see text] –10(3) Hz band of ground-based observatories and the [Formula: see text] –10(− 1) Hz band of LISA lies the uncharted decihertz gravitational-wave band. We propose a Decihertz Observatory to study this frequency range, and to complement observations made by other detectors. …”
Publicado 2021
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532por Badr, Omaima Ibrahim, Elrefaey, Wael Aly, Abu-Zaid, Mohammed Hassan, Elmedany, Samah Hamdy“…Multiple studies have tested antiphospholipid antibodies (aPLs) among COVID-19 patients, but to date, the actual frequency of aPLs is still uncharted. In this cohort study, we analyzed the outcomes of 173 consecutive patients with confirmed COVID-19 infection. …”
Publicado 2022
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533por Gajbhiye, Rahul K, Mahajan, Niraj N, Waghmare, Rakesh, Surve, Suchitra V, Howal, Prashant, Bhurke, Aishwarya, Pious, Merlin, Modi, Deepak N, mahale, Smita D“…However, the consequences of the COVID-19 pandemic on pregnant women and their newborns remain uncharted. The PregCovid registry aims to document the impact of SARS-CoV-2 infection on pregnant, postpartum women and their newborns. …”
Publicado 2022
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534por Kim, Gha-hyun J., Mo, Han, Liu, Harrison, Okorie, Meri, Chen, Steven, Zheng, Jiashun, Li, Hao, Arkin, Michelle, Huang, Bo, Guo, Su“…Together, this work, which combines high content whole organism in vivo imaging-based screen and bioinformatic pathway analysis of the screening dataset, delineates a previously uncharted approach for identifying hit-to-lead candidates and for implicating previously unknown pathways and targets involved in DA neuron protection.…”
Publicado 2022
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535por Singh, Rajesh Kumar, Singh, Pratiksha, Sharma, Anjney, Guo, Dao-Jun, Upadhyay, Sudhir K., Song, Qi-Qi, Verma, Krishan K., Li, Dong-Ping, Malviya, Mukesh Kumar, Song, Xiu-Peng, Yang, Li-Tao, Li, Yang-Rui“…The current work illustrated the significant and novel results of many uncharted endophytic microbial communities in different tissues of sugarcane species, which provides an experimental system to evaluate the biological nitrogen fixation (BNF) mechanism in sugarcane. …”
Publicado 2022
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536por Paoli, Lucas, Ruscheweyh, Hans-Joachim, Forneris, Clarissa C., Hubrich, Florian, Kautsar, Satria, Bhushan, Agneya, Lotti, Alessandro, Clayssen, Quentin, Salazar, Guillem, Milanese, Alessio, Carlström, Charlotte I., Papadopoulou, Chrysa, Gehrig, Daniel, Karasikov, Mikhail, Mustafa, Harun, Larralde, Martin, Carroll, Laura M., Sánchez, Pablo, Zayed, Ahmed A., Cronin, Dylan R., Acinas, Silvia G., Bork, Peer, Bowler, Chris, Delmont, Tom O., Gasol, Josep M., Gossert, Alvar D., Kahles, André, Sullivan, Matthew B., Wincker, Patrick, Zeller, Georg, Robinson, Serina L., Piel, Jörn, Sunagawa, Shinichi“…The biosynthetic potential of microorganisms in the open ocean remains largely uncharted owing to limitations in the analysis of genome-resolved data at the global scale. …”
Publicado 2022
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537por Aiello, Clarice D., Abendroth, John M., Abbas, Muneer, Afanasev, Andrei, Agarwal, Shivang, Banerjee, Amartya S., Beratan, David N., Belling, Jason N., Berche, Bertrand, Botana, Antia, Caram, Justin R., Celardo, Giuseppe Luca, Cuniberti, Gianaurelio, Garcia-Etxarri, Aitzol, Dianat, Arezoo, Diez-Perez, Ismael, Guo, Yuqi, Gutierrez, Rafael, Herrmann, Carmen, Hihath, Joshua, Kale, Suneet, Kurian, Philip, Lai, Ying-Cheng, Liu, Tianhan, Lopez, Alexander, Medina, Ernesto, Mujica, Vladimiro, Naaman, Ron, Noormandipour, Mohammadreza, Palma, Julio L., Paltiel, Yossi, Petuskey, William, Ribeiro-Silva, João Carlos, Saenz, Juan José, Santos, Elton J. G., Solyanik-Gorgone, Maria, Sorger, Volker J., Stemer, Dominik M., Ugalde, Jesus M., Valdes-Curiel, Ana, Varela, Solmar, Waldeck, David H., Wasielewski, Michael R., Weiss, Paul S., Zacharias, Helmut, Wang, Qing Hua“…These properties can be theoretically and experimentally investigated from a quantum information perspective, which has not yet been fully developed. There are uncharted implications for the quantum sciences once chiral couplings can be engineered to control the storage, transduction, and manipulation of quantum information. …”
Publicado 2022
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538por Euskirchen, Eugénie S., Serbin, Shawn P., Carman, Tobey B., Fraterrigo, Jennifer M., Genet, Hélène, Iversen, Colleen M., Salmon, Verity, McGuire, A. David“…As the Arctic region moves into uncharted territory under a warming climate, it is important to refine the terrestrial biosphere models (TBMs) that help us understand and predict change. …”
Publicado 2021
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539“…ABSTRACT: Explaining the causal and functional relationship between balance control and physical activity (PA) when comparing demographic, anthropometric, and eyesight impairment is uncharted. This study aimed to assess the shape of the relationships between balance control and PA and to verify the usefulness of explanatory variables (sex, chronological age, biological age, myopia, and BMI) in explaining the formation of functional forms between both abovementioned variables. …”
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540por Boneh-Shitrit, Tali, Feighelstein, Marcelo, Bremhorst, Annika, Amir, Shir, Distelfeld, Tomer, Dassa, Yaniv, Yaroshetsky, Sharon, Riemer, Stefanie, Shimshoni, Ilan, Mills, Daniel S., Zamansky, Anna“…Emotional states remain uncharted territories, especially in dogs, due to the complexity of their facial morphology and expressions. …”
Publicado 2022
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