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581Recommendations for future university pandemic responses: What the first COVID-19 shutdown taught us“…In doing so, university leaders were thrust into unchartered waters and forced them to make unprecedented decisions. …”
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582“…It was evident that just as other places, Ghana has employed geospatial technologies and continues to ply unchartered paths in solutions. The trend in Ghana is in line with a population concentration and tends to record higher figures in the southern parts. …”
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583“…COVID-19 is a frightening, stress-inducing, and unchartered territory for all. It is suggested that stress, loneliness, and the emotional toll of the pandemic will result in increased numbers of those who will seek psychological intervention, need support, and guidance on how to cope with a time period that none of us were prepared for. …”
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584por Jenni, Peter“…And this is only the beginning of this fantastic journey into unchartered physics territory. The LHC has resumed in 2015 its operation at even higher collision energy, with the exciting prospects to elucidate the mystery of Dark Matter in the Universe, which could be related to a theoretically proposed overarching symmetry in particle physics, called Supersymmetry (SUSY).…”
Publicado 2019
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585por Simerly, C., Castro, C., Hartnett, C., Lin, C. C., Sukhwani, M., Orwig, K., Schatten, G.“…The fertilizing sperm’s lengthiest unchartered voyage is through the longest, least-investigated organ in a man’s body – the Epididymis. …”
Publicado 2016
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586“…While previous studies have explored the impact of histone lactylation in modulating gene expression, the precise role of this epigenetic modification in regulating oncogenes is largely unchartered. In this study, using breast cancer cell lines and their mutants exhibiting lactate-deficient metabolome, we have identified that an enhanced rate of aerobic glycolysis supports c-Myc expression via promoter-level histone lactylation. …”
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587por Newman, Robert H, Hu, Jianfei, Rho, Hee-Sool, Xie, Zhi, Woodard, Crystal, Neiswinger, John, Cooper, Christopher, Shirley, Matthew, Clark, Hillary M, Hu, Shaohui, Hwang, Woochang, Seop Jeong, Jun, Wu, George, Lin, Jimmy, Gao, Xinxin, Ni, Qiang, Goel, Renu, Xia, Shuli, Ji, Hongkai, Dalby, Kevin N, Birnbaum, Morris J, Cole, Philip A, Knapp, Stefan, Ryazanov, Alexey G, Zack, Donald J, Blackshaw, Seth, Pawson, Tony, Gingras, Anne-Claude, Desiderio, Stephen, Pandey, Akhilesh, Turk, Benjamin E, Zhang, Jin, Zhu, Heng, Qian, Jiang“…The landscape of human phosphorylation networks has not been systematically explored, representing vast, unchartered territories within cellular signaling networks. …”
Publicado 2013
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588“…After reviewing conventional treatment and current changes in medical therapy for EAC, we will focus on unchartered grounds such as cancer stem cells, genetics and epigenetics, immunotherapy, and chemoradio-resistant pathways as we simultaneously propose some investigational possibilities that could be applicable to EAC.…”
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589por Bergmann, Samantha, Toussaint, Karen A., Niland, Haven, Sansing, Elizabeth M., Armshaw, Gabriel, Baltazar, Marla“…In response to the need for services, behavior analysts and therapists may find themselves treading unchartered waters as they use telehealth to provide direct intervention to consumers. …”
Publicado 2021
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590“…Many researchers believe that these transcripts represent a vast, unchartered world of functional non-coding RNAs (ncRNAs), simply because they exist. …”
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591“…At the very least, these initiatives will help clarify the stage before and around diagnosis, enabling the field to push into unchartered territory at the earliest stages of disease.…”
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592“…Despite their versatile applicability, such as antifungals, cancer drugs and analytical probes, they still represent a mostly unchartered territory among intramolecular charge-transfer (ICT) dyes. …”
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593“…If PRS-based cancer screening is to be effective, research needs to focus on identifying PRSs associated with cancer mortality, an unchartered and clinically-relevant area of research, with a much higher potential to improve screening outcomes.…”
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594por Nguyen, Nhi T., Jaramillo-Martinez, Valeria, Mathew, Marilyn, Suresh, Varshini V., Sivaprakasam, Sathish, Bhutia, Yangzom D., Ganapathy, Vadivel“…These new discoveries usher this intriguing group of non-traditional progesterone receptors into an unchartered territory in biology and medicine.…”
Publicado 2023
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595por Ciccarelli, Michele, Sorriento, Daniela, Fiordelisi, Antonella, Gambardella, Jessica, Franco, Antonietta, del Giudice, Carmine, Sala, Marina, Monti, Maria Gaia, Bertamino, Alessia, Campiglia, Pietro, Oliveti, Marco, Poggio, Paolo, Trinchese, Giovanna, Cavaliere, Gina, Cipolletta, Ersilia, Mollica, Maria Pina, Bonaduce, Domenico, Trimarco, Bruno, Iaccarino, Guido“…AIMS: The effects of GRK2 inhibition on myocardial metabolism in heart failure (HF) are unchartered. In this work, we evaluated the impact of pharmacological inhibition of GRK2 by a cyclic peptide, C7, on metabolic, biochemical, and functional phenotypes in experimental HF. …”
Publicado 2020
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596por Pandkar, Madhura R, Raveendran, Adarsh, Biswas, Kajal, Mutnuru, Srinivas Abhishek, Mishra, Jharna, Samaiya, Atul, Malys, Tyler, Mitrophanov, Alexander Y, Sharan, Shyam K, Shukla, Sanjeev“…The hypoxic milieu is a critical modulator of aerobic glycolysis, yet the regulatory mechanisms between the key glycolytic enzymes in hypoxic cancer cells are largely unchartered. In particular, the M2 isoform of pyruvate kinase (PKM2), the rate-limiting enzyme of glycolysis, is known to confer adaptive advantages under hypoxia. …”
Publicado 2023
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597por Al-Amoudi, Soha, Essack, Magbubah, Simões, Marta F., Bougouffa, Salim, Soloviev, Irina, Archer, John A. C., Lafi, Feras F., Bajic, Vladimir B.“…Microorganisms that inhabit unchartered unique soil such as in the highly saline and hot Red Sea lagoons on the Saudi Arabian coastline, represent untapped sources of potentially new bioactive compounds. …”
Publicado 2016
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598por Ludvigsen, Martin, Berge, Jørgen, Geoffroy, Maxime, Cohen, Jonathan H., De La Torre, Pedro R., Nornes, Stein M., Singh, Hanumant, Sørensen, Asgeir J., Daase, Malin, Johnsen, Geir“…It also highlights a previously unchartered susceptibility to light pollution in a region destined to see significant changes in light climate due to a reduced ice cover and an increased anthropogenic activity.…”
Publicado 2018
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599por Oh, Seung‐Hyun Victor, Hwang, Woohyun, Kim, Kwangrae, Lee, Ji‐Hwan, Soon, Aloysius“…To expand the unchartered materials space of lead‐free ferroelectrics for smart digital technologies, tuning their compositional complexity via multicomponent alloying allows access to enhanced polar properties. …”
Publicado 2022
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600“…The Covid-19 pandemic has involved nations world-wide in the necessity to manage and control the spread of infection, and challenged organizations to effectively counteract an unchartered medical crisis while preserving the safety of workers. …”
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