“…Patient's perspective in living with and beyond these toxicities remains largely uncharted but essential in optimizing care provided to those receiving treatment with targeted therapies.…”
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“…In particular, the catalytic preparation of a three-dimensional molecular layout of a simple acyclic hydrocarbon skeleton possessing several stereocenters from simple and readily available reagents still represents a vastly uncharted domain. Here, we report a rapid, modular, stereodivergent and diversity-oriented unified strategy to construct acyclic molecular frameworks bearing up to four contiguous and congested stereogenic elements, with remarkably high levels of stereocontrol and in only three catalytic steps from commercially available alkynes. …”
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“…Many clinical trials are now ongoing to test the possibility of TAVI for use in patients even with uncharted indications who are not eligible for SAVR in current guidelines but may benefit from valve replacement. …”
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“…Seat loads are essentially uncharted territory, as most studies only address pedal loading to study cycling technique. …”
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“…It is of remarkable significance in revealing the evolutions in social networks and we hope this work will shed light for more and more forthcoming researchers to further explore the uncharted part of this promising field.…”
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“…However, the performance of such mobile-based AI systems is still uncharted territory. In this article, we discuss the issues of computing resource consumption and performance of the mobile device-based AI systems and highlight recent research on the feasibility and future potential of application of the mobile device-based AI systems in telemedicine.…”
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“…The COVID-19 pandemic has presented practitioners of applied behavior analysis (ABA) with new and uncharted challenges. Upholding ethical responsibilities while navigating an international public health crisis has opened areas of uncertainty that have no precedent. …”
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“…As a result, a notable increase in research on methodology and hardware sophistication has emerged, and many hitherto uncharted chemistries have been achieved. To better help the commercialization of wide-scale electrification of organic synthesis, we highlight in this perspective the advances made in large-scale flow electrosynthesis and its future trajectory while pointing out the main challenges and key improvements of current methodologies.…”
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“…Finally, new ideas are introduced and evidence-based hypotheses are presented on the following five themes: periodization, exploration, virtual (at-home) training, player monitoring, and continued education, including return-to-competition preparation strategies following these exceptional times of uncharted territory.…”
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“…Cancellation of away electives, as well as changes to the format, timeline, and requirements of mandatory medical licensing exams has left IMG residency applicants in uncharted territory. Given that IMGs comprise up to 25% of the Canadian healthcare force, and often are based in underserviced areas, the licensure and eligibility of IMGs to continue to enter the Canadian healthcare force is of the utmost importance in the midst of the COVID-19 pandemic. …”
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“…Whether and how endocrine fluctuations also exert an influence on perceptual abilities is largely uncharted. Here, we show that phasic increases in GC availability prove beneficial to auditory discrimination. …”
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“…However, the utility of medications targeting HRD cancer cells is an uncharted territory in melanoma. Moreover, preclinical evidence suggests a synergistic role of combining immune checkpoint blockade (ICB) with drugs targeting HRD cancer cells such as PARP inhibitors. …”
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“…Upon return to elective surgery in May, 2020, the hospital found itself navigating uncharted territory. The unpredictability of the post-pandemic environment has required the healthcare team to constantly reassess and revise processes to ensure optimal patient outcomes, as well as safe practices for staff providing perioperative care. …”
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“…The use of ultra-low pressure, often simply by hydrostatic force (often called gravity-driven membrane (GDM) filtration), makes it fall into the uncharted territory of common pressure-driven membrane filtration. …”
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“…A surprisingly large fraction of the human interactome remains uncharted, which we refer to as the “dark interactome.” …”
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“…As our knowledge of oncogenic mechanisms across various malignancies has matured, it’s become increasingly clear that numerous properties of tumors transcend their genomes – leading to new and uncharted frontiers of therapeutic opportunity. In this review, we discuss how the implementation of cutting-edge tools and approaches is opening new windows into chordoma’s vulnerabilities. …”
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“…Marine pharmacology represents a relatively uncharted territory to seek promising compounds, despite the enormous chemodiversity it offers. …”
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“…Furthermore, in the context of the studies for possible future accelerators, some uncharted territories remain such as, for instance, the collective instabilities during the necessary ionization cooling for a muon collider.…”
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“…Four distinctive features make this measurement one of the more extensive and detailed tests of the jet physics at hadron colliders: (a) the measurement can profit of the unprecedented collision intensity and center-of-mass energy of sqrt(s) = 7 TeV provided by the Large Hadron Collider, overcoming the highest measured jet energies in previous experiments; (b) the wide solid angle coverage of the ATLAS experiment allow the measurement of the cross section in uncharted angular regions; (c) the quality of the ATLAS measurement of jets at low energies allow the extension of the cross section measurement to really low energy; (d) the jet cross section profits of the new anti-kt jet definition developed in the last couple of years, which overcame most of the problems of the previous definitions.…”
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“…The Gamma Factory could open new research opportunities in a vast domain of uncharted fundamental physics and industrial application territories. …”
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