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Mostrando 841 - 860 Resultados de 1,763 Para Buscar '"Usher"', tiempo de consulta: 0.23s Limitar resultados
  1. 841
    “…Plausible scenarios for land-use change indicate that increasing extraction pressure on Central African forests is likely to usher in new worker populations and to intensify the hunting impacts and trophic cascade disruption already in progress, unless serious efforts are made for hunting regulation. …”
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    Extent and ecological consequences of hunting in Central African rainforests in the twenty-first century
  2. 842
    “…However, AAV's limited cargo capacity prevents its application to therapies of inherited retinal diseases due to mutations of genes over 5 kb, like Stargardt's disease (STGD) and Usher syndrome type IB (USH1B). Previous methods based on ‘forced’ packaging of large genes into AAV capsids may not be easily translated to the clinic due to the generation of genomes of heterogeneous size which raise safety concerns. …”
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    Effective delivery of large genes to the retina by dual AAV vectors
  3. 843
    “…These domains have been linked to many disease processes including common Avian influenza, as well as very rare conditions such as Fraser and Usher syndromes. Historically, based on the interactions and the nature of bonds they form, PDZ domains have most often been classified into one of three classes (class I, class II and others - class III), that is directly dependent on their binding partner. …”
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    Application of Wavelet Transform for PDZ Domain Classification
  4. 844
    “…By analyzing all the possible fimbrial operons in UPEC strains, we found that closely related strains had similar types of chaperone-usher fimbriae, and the diversity of fimbrial genes was higher than that of multilocus sequence typing (MLST) genes. …”
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    A High-resolution Typing Assay for Uropathogenic Escherichia coli Based on Fimbrial Diversity
  5. 845
    “…To date, mutations detected in CIB2 are causative for nonsyndromic hearing loss (DFNB48) or Usher syndrome type 1 J. Patients harboring biallelic CIB2 mutations suffer from bilateral, early onset, moderate to profound HI. …”
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    Advances in genetic hearing loss: CIB2 gene
  6. 846
    “…Usher syndrome (USH) is a rare autosomal recessive disease and the most common inherited form of combined visual and hearing impairment. …”
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    USH2A Gene Editing Using the CRISPR System
  7. 847
    “…Mutations in the gene encoding harmonin, a multi‐PDZ domain‐containing submembrane protein, cause Usher syndrome type 1 (congenital deafness and balance disorder, and early‐onset sight loss). …”
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    Conformational switch of harmonin, a submembrane scaffold protein of the hair cell mechanoelectrical transduction machinery
  8. 848
    por Persson, Karina, Hall, Michael
    Publicado 2017
    “…While the assembly of the type-1 fimbriae from Escherichia coli is well studied; the chaperone-usher pathway, very little is known about the polymerization of P. gingivalis fimbriae. …”
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    Structural and functional studies of Porphyromonas gingivalis fimbrial proteins
  9. 849
    “…Uropathogenic E. coli (UPEC), which cause urinary tract infections (UTI), utilize type 1 pili, a chaperone usher pathway (CUP) pilus, to cause UTI and colonize the gut. …”
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    Functional role of the type 1 pilus rod structure in mediating host-pathogen interactions
  10. 850
    “…This strategy would still not suffice for treatment of IRDs such as Usher syndrome type 1D or Alström syndrome type I (ALMS) due to mutations in CDH23 or ALMS1, respectively. …”
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    Triple Vectors Expand AAV Transfer Capacity in the Retina
  11. 851
    “…This is no more evident than in the discovery and manufacture of Synthetic Biological Materials, where synthetic biology has the capacity to usher in a new Materials from Biology era that will revolutionise the discovery and manufacture of innovative synthetic biological materials. …”
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    A living foundry for Synthetic Biological Materials: A synthetic biology roadmap to new advanced materials
  12. 852
    “…Biofilm formation is mediated by Csu pili, assembled via the “archaic” chaperone–usher pathway. The X-ray structure of the CsuC-CsuE chaperone–adhesin preassembly complex reveals the basis for bacterial attachment to abiotic surfaces. …”
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    Structural basis for Acinetobacter baumannii biofilm formation
  13. 853
    “…We envisage that 1,6‐HD may serve as a lead substance and usher in the design of potent new strategies to increase nuclear delivery of therapeutic nanoparticles.…”
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    Facilitating plasmid nuclear delivery by interfering with the selective nuclear pore barrier
  14. 854
    “…Recent advancements could usher in a new era of highly personalized medicine in EOC.…”
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    Organoids of epithelial ovarian cancer as an emerging preclinical in vitro tool: a review
  15. 855
    “…In addition, the distinct genetic differences between CL-1 and the other Thermosynechococcus strains are related to photosynthesis, transporters, signal transduction, the chaperone/usher system, nitric oxide protection, antibiotic resistance, prokaryotic immunity systems, and other physiological processes. …”
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    Comparative Genomic Analysis of a Novel Strain of Taiwan Hot-Spring Cyanobacterium Thermosynechococcus sp. CL-1
  16. 856
    por Hafeez, Adam S., Bavry, Anthony A.
    Publicado 2020
    “…As therapeutic advancements such as tafamidis usher in a promising new era in the management of ATTR-CM, the need for disease awareness and efficient diagnostic evaluation is crucial. …”
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    Diagnosis of Transthyretin Amyloid Cardiomyopathy
  17. 857
    “…Improved molecular insight into the condition promises to usher in novel forms of therapy that will lead to improved care at the clinical bedside.…”
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    Arrhythmogenic Cardiomyopathy: Molecular Insights for Improved Therapeutic Design
  18. 858
    “…In both mice and cynomolgus macaques, AAV-S mediates highly efficient reporter gene expression in a variety of cochlear cells, including inner and outer hair cells, fibrocytes, and supporting cells. In a mouse model of Usher syndrome type 3A, AAV-S encoding CLRN1 robustly and durably rescues hearing. …”
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    AAV-S: A versatile capsid variant for transduction of mouse and primate inner ear
  19. 859
    “…By ensuring the ethical inclusion of vulnerable groups in the vaccine development process and making a safe, effective vaccine accessible to all, pharmaceutical companies, governments, and international organisations can usher in a new era of global health that relies solely on ethical decision making.…”
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    Time for the ethical management of COVID-19 vaccines
  20. 860
    por Dietert, Rodney R.
    Publicado 2021
    “…The is a sequential article to an initial review suggesting that Microbiome First medical approaches to human health and wellness could both aid the fight against noncommunicable diseases and conditions (NCDs) and help to usher in sustainable healthcare. This current review article specifically focuses on public health programs and initiatives and what has been termed by medical journals as a catastrophic record of recent failures. …”
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    Microbiome First Approaches to Rescue Public Health and Reduce Human Suffering
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