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  1. 1021
    por Gopal, Murali, Gupta, Alka
    Publicado 2016
    “…This fresh knowledge of the microbiome, particularly of the rhizosphere, offering genetic variability to plants, opens up new horizons for breeding that could usher in cultivation of next-generation crops depending less on inorganic inputs, resistant to insect pest and diseases and resilient to climatic perturbations. …”
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    Microbiome Selection Could Spur Next-Generation Plant Breeding Strategies
  2. 1022
    “…Here we describe the distribution and levels of mRNA encoding 11 key genes involved in Nogo-like signaling (Nogo-A, Oligodendrocyte-Myelin glycoprotein (OMgp), Nogo receptor 1 (NgR1), NgR2, NgR3, Lingo-1, TNF receptor orphan Y (Troy), Olfactomedin, Lateral olfactory tract usher substance (Lotus) and membrane-type matrix metalloproteinase-3 (MT3-MPP)), as well as BDNF and GAPDH. …”
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    Spatiotemporal and Long Lasting Modulation of 11 Key Nogo Signaling Genes in Response to Strong Neuroexcitation
  3. 1023
    “…Ultimately, our MPs system strives to usher a new research area in smart drug delivery systems and advance the current oral drug delivery technology by solving major challenges in targeted delivery of pH-sensitive therapeutics.…”
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    Smart Microparticles with a pH-responsive Macropore for Targeted Oral Drug Delivery
  4. 1024
    “…Here, we studied two previously uncharacterized pESI-encoded chaperone-usher fimbriae, named Ipf and Klf. While Ipf homologs are rare and were found only in S. enterica subspecies diarizonae and subspecies VII, Klf is related to the known K88-Fae fimbria and klf clusters were identified in seven S. enterica subspecies I serovars, harboring interchanging alleles of the fimbria major subunit, KlfG. …”
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    The plasmid-encoded Ipf and Klf fimbriae display different expression and varying roles in the virulence of Salmonella enterica serovar Infantis in mouse vs. avian hosts
  5. 1025
    “…UPEC isolates encode up to 16 distinct chaperone-usher pathway (CUP) pili and each pilus type likely enables colonization of a habitat in the host or environment(7). …”
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    Selective depletion of uropathogenic E. coli from the gut by a FimH antagonist
  6. 1026
    “…PURPOSE: Usher syndrome (US) is characterized by a loss of vision due to retinitis pigmentosa (RP) and deafness. …”
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    The genetic dissection of Myo7a gene expression in the retinas of BXD mice
  7. 1027
    “…Treatments available to cure HCV and control HBV, as well as vaccination to prevent HBV infection, have certainly allowed for such bold goals, yet the final steps to usher in elimination require further evidence. DISCUSSION: We broadly discuss the needs for three major public health approaches. …”
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    Research gaps in viral hepatitis
  8. 1028
    “…Both of these genes are known to cause autosomal recessive non-syndromic hearing impairment and Usher syndrome. The protein products of PCDH15 and USH1G function together at the stereocilia tips in the hair cells and are necessary for proper mechanotransduction. …”
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    Novel digenic inheritance of PCDH15 and USH1G underlies profound non-syndromic hearing impairment
  9. 1029
    “…These results may pave the way to far more exotic organic devices with magnetic-field-coupled organic systems that are poised to usher in an era of dynamic spintronics at room temperature.…”
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    Tailoring spin mixtures by ion-enhanced Maxwell magnetic coupling in color-tunable organic electroluminescent devices
  10. 1030
    “…Caf1 is formed into long polymeric fimbriae by a periplasmic chaperone (Caf1M) and outer membrane usher (Caf1A). All three are encoded on an operon regulated by an AraC-type transcription factor Caf1R. …”
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    Induction of the immunoprotective coat of Yersinia pestis at body temperature is mediated by the Caf1R transcription factor
  11. 1031
    “…A. baumannii A118 behaved as non-motile but included the csuA/BABCDE chaperone-usher pilus assembly operon and produced biofilms on polystyrene and glass surfaces. …”
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    Identification of Potential Virulence Factors in the Model Strain Acinetobacter baumannii A118
  12. 1032
    “…The main syndromic causes were: Usher syndrome (8 casess), Waardenbourg syndrome (5 cases), Alport syndrome (3 cases), Wolfram syndrome (2 cases), Goldenhar syndrome (3 cases), Cogan syndrome (3 cases), Franceschetti-Kleinsyndrome (1 case), Charge syndrome(1 case), otomandibular syndrome (1 case), Stickler syndrome(1 case), Alström syndrome (1 case), Refsum disease (1 case), Susac syndrome (1 case) and KID Syndrome (1 case). …”
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    Dépistage de l'atteinte oculaire chez les enfants sourds
  13. 1033
    “…Results: The c.11864G>A mutation represents the vast majority of pathogenic alleles in Slovenian USH2A-Usher syndrome population (84%). The median age of onset of nyctalopia was 16 years and all patients younger than 40 years had hyperautofluorescent rings on fundus autofluorescence imaging. …”
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    Clinical and Haplotypic Variability of Slovenian USH2A Patients Homozygous for the c. 11864G>A Nonsense Mutation
  14. 1034
    “…Non-syndromic hearing impairment (NSHI) is the most frequent clinical entity and accounts for 86.1% to 92.5% of cases of HI of genetic origin. Waardenburg and Usher syndromes account for 50% to 57.14% and 8.9% to 42.9% of genetic syndromic cases, respectively. …”
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    Hearing Impairment Overview in Africa: the Case of Cameroon
  15. 1035
    “…At the same time, it demonstrates for the first time p-type and remarkable n-type conductivity in Ga(2)O(3) which should usher in the development of Ga(2)O(3) devices and advance optoelectronics and high-power devices.…”
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    Chemical manipulation of hydrogen induced high p-type and n-type conductivity in Ga(2)O(3)
  16. 1036
    “…CONCLUSIONS: The Microbial Theory of Health, including age-appropriate and health-appropriate hygiene practices for home and everyday life, should usher in a new era in which pathogen reduction can be accomplished without indiscriminate elimination of potentially beneficial microbes from the human and environmental microbiomes.…”
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    A 21st century view of infection control in everyday settings: Moving from the Germ Theory of Disease to the Microbial Theory of Health
  17. 1037
    “…USH2A variants are the most common cause of Usher syndrome type 2, characterized by congenital sensorineural hearing loss and retinitis pigmentosa (RP), and also contribute to autosomal recessive non-syndromic RP. …”
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    Clinical and preclinical therapeutic outcome metrics for USH2A-related disease
  18. 1038
    “…Further, a major Fisheries Development Scheme(PMMSY) with a financial outlay of 267 million USD has been announced to usher in a blue revolution by strengthening the value chain, doubling the fisher/farmer income, employment generation, economic and social security for fishers/fish farmers adhering to the sustainability principles. …”
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    Prospective impact of Corona virus disease (COVID-19) related lockdown on shrimp aquaculture sector in India – a sectoral assessment
  19. 1039
    por Rajewsky, Nikolaus, Almouzni, Geneviève, Gorski, Stanislaw A., Aerts, Stein, Amit, Ido, Bertero, Michela G., Bock, Christoph, Bredenoord, Annelien L., Cavalli, Giacomo, Chiocca, Susanna, Clevers, Hans, De Strooper, Bart, Eggert, Angelika, Ellenberg, Jan, Fernández, Xosé M., Figlerowicz, Marek, Gasser, Susan M., Hubner, Norbert, Kjems, Jørgen, Knoblich, Jürgen A., Krabbe, Grietje, Lichter, Peter, Linnarsson, Sten, Marine, Jean-Christophe, Marioni, John C., Marti-Renom, Marc A., Netea, Mihai G., Nickel, Dörthe, Nollmann, Marcelo, Novak, Halina R., Parkinson, Helen, Piccolo, Stefano, Pinheiro, Inês, Pombo, Ana, Popp, Christian, Reik, Wolf, Roman-Roman, Sergio, Rosenstiel, Philip, Schultze, Joachim L., Stegle, Oliver, Tanay, Amos, Testa, Giuseppe, Thanos, Dimitris, Theis, Fabian J., Torres-Padilla, Maria-Elena, Valencia, Alfonso, Vallot, Céline, van Oudenaarden, Alexander, Vidal, Marie, Voet, Thierry
    Publicado 2020
    “…The application of this strategy to key medical challenges in cancer, neurological and neuropsychiatric disorders, and infectious, chronic inflammatory and cardiovascular diseases at the single-cell level will usher in cell-based interceptive medicine in Europe over the next decade.…”
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    LifeTime and improving European healthcare through cell-based interceptive medicine
  20. 1040
    “…In two additional cases–syndromic blindness had been proposed before, but not specifically diagnosed, and one patient with Heimler syndrome had been misdiagnosed as an Usher case before testing. 33.3% of the genetically diagnosed patients (15/45) had causative variants in genes targeted by clinical trials exploring the curative potential of gene therapy approaches. …”
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    Comprehensive genomic diagnosis of inherited retinal and optical nerve disorders reveals hidden syndromes and personalized therapeutic options
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