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  1. 1061
    “…We demonstrate that targeted adaptive long-read sequencing on the Oxford Nanopore Technologies (ONT) platform of the USH2A gene from three probands in a family with the most common cause of the syndromic IRD, Usher Syndrome, resulted in greater than 12-fold target gene sequencing enrichment on average. …”
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    Targeted adaptive long-read sequencing for discovery of complex phased variants in inherited retinal disease patients
  2. 1062
    “…We anticipate that this distributable technology to generate clinical-grade [(18)F]FDT directly from the widely-available clinical reagent [(18)F]FDG, without need for either bespoke radioisotope generation or specialist chemical methods and/or facilities, could now usher in global, democratized access to a TB-specific PET tracer.…”
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    Distributable, Metabolic PET Reporting of Tuberculosis
  3. 1063
    “…Uropathogenic Escherichia coli express hairlike proteinaceous surface projections, known as chaperone–usher pathway (CUP) pili. Type 1 pili are CUP pili with well-established pathogenic properties. …”
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    FimH and Type 1 Pili Mediated Tumor Cell Cytotoxicity by Uropathogenic Escherichia coli In Vitro
  4. 1064
    “…Generating maps for every protein encoding gene and regulatory element in the human genome would create an ‘Atlas’ of variant effect maps and transform our understanding of genetics and usher in a new era of nucleotide-resolution functional knowledge of the genome. …”
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    An Atlas of Variant Effects to understand the genome at nucleotide resolution
  5. 1065
    “…This review focuses on how HIF inhibitors could be applied in conjunction with current cancer treatments, including those now being evaluated in clinical trials, to usher in a new era of cancer therapy.…”
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    Novel cancer treatment paradigm targeting hypoxia-induced factor in conjunction with current therapies to overcome resistance
  6. 1066
    “…With the solution of follow-up related problems and the application of novel technologies, telemedicine may usher in greater development.…”
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    Application of telemedicine system on the management of general patient in quarantine
  7. 1067
    “…By harnessing the potential of smart nanoparticles, this review aims to usher in a new era of precise and personalized cancer therapy, providing patients with individualized treatment options.…”
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    Smart nanoparticles for cancer therapy
  8. 1068
    “…Genotype–phenotype correlations for Usher syndrome type 2 (USH2) suggest that the USH2A gene exhibits an allelic hierarchy. …”
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    Allelic hierarchy for USH2A influences auditory and visual phenotypes in South Korean patients
  9. 1069
    “…The results show that the natural length distribution of adhesive pili formed via the chaperone-usher pathway results from a stochastic chain termination reaction. …”
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    Stochastic chain termination in bacterial pilus assembly
  10. 1070
    “…Mutations in the CLRN1 gene cause Usher syndrome type 3 (USH3), a human disease characterized by progressive blindness and deafness. …”
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    CLRN1 Is Nonessential in the Mouse Retina but Is Required for Cochlear Hair Cell Development
  11. 1071
    por Hui, Shirley, Bader, Gary D
    Publicado 2010
    “…Based on our results, new protein interactions potentially associated with Usher and Bardet-Biedl syndromes were predicted. …”
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    Proteome scanning to predict PDZ domain interactions using support vector machines
  12. 1072
    “…By using periodic Leslie–Usher matrices and a simulation approach together with parameters obtained from long-term field projects, we reconstructed the underlying mechanisms of predator–prey demographic interactions and compared the dynamics of the roe deer–red fox–Eurasian lynx–human harvest system with those of the moose–brown bear–gray wolf–human harvest system in the boreal forest ecosystem of the southern Scandinavian Peninsula. 3. …”
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    Predicting the potential demographic impact of predators on their prey: a comparative analysis of two carnivore–ungulate systems in Scandinavia
  13. 1073
    “…In silico prediction tools were used to determine mutational impact on protein function and the structure of the identified variants. RESULTS: Novel Usher syndrome type 2A (USH2A) compound heterozygous mutations, c.4325T>C (p.F1442S) and c.15188T>G (p.L5063R), located in exons 20 and 70, respectively, were identified as probable causative mutations for RP in this family. …”
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    Whole-exome sequencing identifies novel compound heterozygous mutations in USH2A in Spanish patients with autosomal recessive retinitis pigmentosa
  14. 1074
    “…The bacterium can produce serious complications in those infected, and emerging resistance to third generation cephalosporins could usher in an era of potentially untreatable gonorrhea. …”
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    Behavioral and Socioeconomic Risk Factors Associated with Probable Resistance to Ceftriaxone and Resistance to Penicillin and Tetracycline in Neisseria gonorrhoeae in Shanghai
  15. 1075
    “…These genes were ACTG1, DFNA5, POU4F3, SLC26A5, SIX1, MYO7A, CDH23, PCDH15, and USH2A, suggesting that a variety of genes underlie early-childhood hearing loss in Japanese patients. Mutations in Usher syndrome-related genes were detected in three families, including one double heterozygous mutation of CDH23 and PCDH15. …”
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    Diverse spectrum of rare deafness genes underlies early-childhood hearing loss in Japanese patients: a cross-sectional, multi-center next-generation sequencing study
  16. 1076
    “…Typhi) stg operon, encoding a chaperone/usher fimbria (CU), contributes to an increased adherence to human epithelial cells. …”
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    stg fimbrial operon from S. Typhi STH2370 contributes to association and cell disruption of epithelial and macrophage-like cells
  17. 1077
    “…The first step in the process of establishing an infection is adherence of the bacteria to target cells. Chaperone-usher pili assembly systems are involved in pilus biogenesis pathways that play an important role in adhesion to host cells and tissues as well as medically relevant surfaces. …”
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    Analysis of the role of the LH92_11085 gene of a biofilm hyper-producing Acinetobacter baumannii strain on biofilm formation and attachment to eukaryotic cells
  18. 1078
    “…The clinical overlap of HS with the more common Usher syndrome and lack of peroxisomal abnormalities on plasma screening suggest that HS may be under-diagnosed. …”
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    Spectrum of PEX1 and PEX6 variants in Heimler syndrome
  19. 1079
    “…Pathogenic genotypes were identified in 19 different genes, with a high prevalence of GJB2, STRC, MYO15A, OTOF, TMC1, MYO7A and USH2A. Involvement of an Usher gene was reported in 16% of the genotyped cohort. …”
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    Combined genetic approaches yield a 48% diagnostic rate in a large cohort of French hearing-impaired patients
  20. 1080
    “…Uropathogenic Escherichia coli (UPEC) employs multiple chaperone–usher pathway pili tipped with adhesins with diverse receptor specificities to colonize various host tissues and habitats. …”
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    Structure-based discovery of glycomimetic FmlH ligands as inhibitors of bacterial adhesion during urinary tract infection
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