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21“…Phylogenetic analysis revealed two bovine IGHV families (boVH1, boVH2). Thus, the existence of the two bovine families suggested was demonstrated, where boVH1 comprises all functional segments. …”
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22por Kishore, Kamal“…METHODS: A retrospective, noncomparative, interventional case series of 4 eyes of 4 patients (all female, aged 68–91 years, 3 treatment naive) treated with IAI 2 mg for complications of RAM [macular edema (ME) 2, submacular hemorrhage (SMH) 1, and vitreous hemorrhage (VH) 1] was conducted. Baseline parameters consisted of complete ocular examination, medical history, best-corrected Snellen VA, fundus photography, IVFA and SD OCT, unless precluded by VH (1). …”
Publicado 2016
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23por Zhao, Aizhi, Qin, Weijun, Han, Yueheng, Wen, Weihong, Zhang, Wenhong, Lian, Zhonghui, Chen, Gang, Zhang, Zhuoli, Peng, Jianqiang, Wang, He, Guo, Yinglu“…Sequence analysis revealed that the VL gene was composed of VL3 h (V lambda subgroup) and JL2 regions and the VH gene was composed of VH1-69 (VH1 subgroup), D2-15, D3-22 and JH6 regions. …”
Publicado 2007
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24por Souto-Carneiro, Maria M, Krenn, Veit, Hermann, Ralph, König, Achim, Müller-Hermelink, Hans-Konrad“…The amino acid sequences that belonged to the VH1-family obtained from the three anatomical regions were primarily compared with the amino acid sequences of their closest germline counterparts (Fig. 1a). …”
Publicado 2000
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25Publicado 1996“…Rabbits are born with a limited VDJ gene repertoire formed primarily by rearrangement of one VH gene, VH1. The VDJ genes are undiversified at birth but become diversified by approximately 2 mo of age. …”
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26por Brouwer, Philip J. M., Caniels, Tom G., van der Straten, Karlijn, Snitselaar, Jonne L., Aldon, Yoann, Bangaru, Sandhya, Torres, Jonathan L., Okba, Nisreen M. A., Claireaux, Mathieu, Kerster, Gius, Bentlage, Arthur E. H., van Haaren, Marlies M., Guerra, Denise, Burger, Judith A., Schermer, Edith E., Verheul, Kirsten D., van der Velde, Niels, van der Kooi, Alex, van Schooten, Jelle, van Breemen, Mariëlle J., Bijl, Tom P. L., Sliepen, Kwinten, Aartse, Aafke, Derking, Ronald, Bontjer, Ilja, Kootstra, Neeltje A., Wiersinga, W. Joost, Vidarsson, Gestur, Haagmans, Bart L., Ward, Andrew B., de Bree, Godelieve J., Sanders, Rogier W., van Gils, Marit J.“…These antibodies had low levels of somatic hypermutation and showed a strong enrichment in VH1-69, VH3-30-3, and VH1-24 gene usage. A subset of the antibodies was able to potently inhibit authentic SARS-CoV-2 infection at a concentration as low as 0.007 micrograms per milliliter. …”
Publicado 2020
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27por Ollier, Romain, Fuchs, Aline, Gauye, Florence, Piorkowska, Katarzyna, Menant, Sébastien, Ratnam, Monisha, Montanari, Paolo, Guilhot, Florence, Phillipe, Didier, Audrain, Mickael, Egesipe, Anne-Laure, Névoltris, Damien, Seredenina, Tamara, Pfeifer, Andrea, Kosco-Vilbois, Marie, Afroz, Tariq“…Murine mAb targeting TDP-43, ACI-5891, was humanized on a framework (VH1–3/VK2–30) selected based on the highest sequence homology. …”
Publicado 2023
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28por Li, Liuzhe, Wang, Xiao-Hong, Banerjee, Sagarika, Volsky, Barbara, Williams, Constance, Virland, Diana, Nadas, Arthur, Seaman, Michael S., Chen, Xuemin, Spearman, Paul, Zolla-Pazner, Susan, Gorny, Miroslaw K.“…Analysis revealed that biased usage of Ig genes was restricted only to anti-HIV-1 but not to non-HIV-1 mAbs. The VH1 family genes were dominantly used, followed by VH3, VH4, and VH5 among anti-HIV-1 mAbs, while non-HIV-1 specific mAbs preferentially used VH3 family genes, followed by VH4, VH1 and VH5 families in a pattern identical to Abs derived from healthy individuals. …”
Publicado 2012
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29por Deng, Zhenling, Wang, Xinyao, Liu, Yue, Tian, Xinyu, Deng, Shaohui, Sun, Yingchun, Wang, Song, Zheng, Danxia, Cui, Zhuan, Pan, Yuejuan, A, Lata, Yan, Huige, Qiu, Xiaoyan, Wang, Yue“…Compared with B cell-derived IgG, PTEC-derived IgG displayed less diversity of V(H)DJ(H) rearrangements, predominant VH1-24/DH2-15/JH4 sequences, biased VH1 usage, centralized VH gene segment location at the 3′ end of the genome and non-Gaussian distribution of the CDR3 length. …”
Publicado 2020
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30por He, Ping, Liu, Banghui, Gao, Xijie, Yan, Qihong, Pei, Rongjuan, Sun, Jing, Chen, Qiuluan, Hou, Ruitian, Li, Zimu, Zhang, Yanjun, Zhao, Jincun, Sun, Hao, Feng, Bo, Wang, Qian, Yi, Haisu, Hu, Peiyu, Li, Pingchao, Zhang, Yudi, Chen, Zhilong, Niu, Xuefeng, Zhong, Xiaolin, Jin, Liang, Liu, Xiaofeng, Qu, Kun, Ciazynska, Katarzyna A., Carter, Andrew P., Briggs, John A. G., Chen, Jizheng, Liu, Jinsong, Chen, Xinwen, He, Jun, Chen, Ling, Xiong, Xiaoli“…We report that SARS-CoV-2 infection elicits a population immune response that is mediated by a lineage of VH1-69 germline antibodies. A representative antibody R1-32 from this lineage was isolated. …”
Publicado 2022
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31Publicado 1995“…The nucleotide sequences of rearranged T15 VH1 genes were determined from polymerase chain reaction amplifications of genomic DNA from microdissected GC B cells. …”
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32por Litwińska, Ewelina, Nowak, Marek, Kolasa-Zwierzchowska, Dorota, Nowińska-Serwach, Anna, Władziński, Jacek, Szpakowski, Artur, Szpakowski, Marian, Wilczyński, Jacek R.“…The intraoperative blood loss (VH 1.3 ± 1.1 vs. LAVH 1.4 ± 0.9 g/dl; p = 0.2) and the rate of intra- and postoperative complications were similar in both groups studied. …”
Publicado 2014
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33por Del Padre, Martina, Marrapodi, Ramona, Minafò, Ylenia A., Piano Mortari, Eva, Radicchio, Giovanna, Bocci, Chiara, Gragnani, Laura, Camponeschi, Alessandro, Colantuono, Stefania, Stefanini, Lucia, Basili, Stefania, Carsetti, Rita, Fiorilli, Massimo, Casato, Milvia, Visentini, Marcella“…INTRODUCTION: Hepatitis C virus (HCV) causes mixed cryoglobulinemia (MC) by driving clonal expansion of B cells expressing B cell receptors (BCRs), often encoded by the VH1-69 variable gene, endowed with both rheumatoid factor (RF) and anti-HCV specificity. …”
Publicado 2023
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34por Parreño, Viviana, López, María Virginia, Rodriguez, Daniela, Vena, María Marta, Izuel, Mercedes, Filippi, Jorge, Romera, Alejandra, Faverin, Claudia, Bellinzoni, Rodolfo, Fernandez, Fernando, Marangunich, Laura“…The guinea pig model showed a dose–response relationship to the BoVH-1 antigen concentration in the vaccine and it was able to discriminate among vaccines containing 1 log(10) difference in its BoHV-1 concentration with very good repeatability and reproducibility (CV ≤ 20%). …”
Publicado 2010
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35Publicado 1991“…Three of the four cell lines use the VH11 gene and one uses the VH1 gene. These antibodies exhibit many characteristics of pathogenic anti-DNA antibodies. …”
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36por Li, Changqiao“…The signal strength, defined as the ratio between the measured cross section times branching ratio and the SM prediction, is measured with the 2015-2017 dataset to be $\mu^{bb}_{VH} = 1.16^{+0.27}_{-0.25} = 1.16\pm 0.16~\mathrm{(stat.)}^{+0.21}_{-0.19}~\mathrm{(syst.)}$, indicating good agreement with the SM. …”
Publicado 2019
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37“…Binding of one established inhibitor to the vaccinia virus VH1-related (VHR) phosphatase was directly measured with microcalorimetry, confirming multiple inhibitor binding with equilibrium constants obtained from corresponding inhibition curves. …”
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38por Rowley, Anne, Baker, Susan, Arrollo, David, Gruen, Leah, Tetyana, Bodnar, Innocentini, Nancy, Shulman, Stanford“…These 6 Mab derived from 3 KD patients, all of whom had coronary aneurysms, and were VH3-74 (n = 1), VH3-33 (n = 2, single patient), VH1-45 (n = 1), and VH3-72 (n = 2, single patient). …”
Publicado 2019
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39“…Neither interferon nor reverse transcriptase could be detected in these cultures and the presence of defective interfering particles could not be demonstrated. VH1 and VH4 coronaviruses, isolated from these persistently infected cultures (HV) and identified by 229E antiserum neutralization, were more cytocidal than the parent virus as judged by plaque characteristics and CPE however, they were indistinguishable on the basis of density, EM morphology, and genome size. …”
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40por Parks, K. Rachael, MacCamy, Anna J., Trichka, Josephine, Gray, Matthew, Weidle, Connor, Borst, Andrew J., Khechaduri, Arineh, Takushi, Brittany, Agrawal, Parul, Guenaga, Javier, Wyatt, Richard T., Coler, Rhea, Seaman, Michael, LaBranche, Celia, Montefiori, David C., Veesler, David, Pancera, Marie, McGuire, Andrew, Stamatatos, Leonidas“…Broadly HIV-1 neutralizing VRC01 class antibodies target the CD4-binding site of Env. They are derived from VH1–2*02 antibody heavy chains paired with rare light chains expressing 5-amino acid-long CDRL3s. …”
Publicado 2019
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