Mostrando 41 - 60 Resultados de 84 Para Buscar '"VH1"', tiempo de consulta: 0.14s Limitar resultados
  1. 41
    “…The Env-specific immunoglobulin repertoire of the plasmablasts is dominated by VH1 gene usage and targeting of the V3 region. Numerous plasmablast-derived immunoglobulin lineages persisted in the bone marrow >8 months after immunization, including in the CD138(+) long-lived plasma cell compartment. …”
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    Persistence of HIV-1 Env-Specific Plasmablast Lineages in Plasma Cells after Vaccination in Humans
  2. 42
    “…The Beta-elicited cross-reactive antibodies share genetic and structural features with wildtype-elicited antibodies, including a public VH1-58 clonotype targeting the RBD ridge. These findings advance our understanding of the antibody response to SARS-CoV-2 shaped by antigenic drift with implications for design of next-generation vaccines and therapeutics.…”
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    SARS-CoV-2 Beta variant infection elicits potent lineage-specific and cross-reactive antibodies
  3. 43
    “…In this work, we asked whether two previously identified human cross-neutralizing nAbs, iB14 (class VH1-58) and iB20 (class VH3-53/66), are capable of neutralizing the recently emerged Omicron (BA.1) variant. …”
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    VH3-53/66-Class RBD-Specific Human Monoclonal Antibody iB20 Displays Cross-Neutralizing Activity against Emerging SARS-CoV-2 Lineages
  4. 44
    Publicado 1993
    “…Binding to SPA in ELISA occurred with 15 of 15 VH3 IgM, but none of 12 IgM from the VH1, VH4, VH5, or VH6 families. The VH sequences of the 27 IgM were derived from 20 distinct VH elements, including 11 from the VH3 family. …”
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    The structural basis of germline-encoded VH3 immunoglobulin binding to staphylococcal protein A
  5. 45
    “…Finally, a cross-linking analysis of the cadherin–catenin complex indicated that a large loop located in the middle of the p120 arm-repeat domain is in close spatial vicinity to the amino-terminal VH1 domain of α-catenin. The six amino acid–long extension of this loop, caused by an alternative splicing, weakens p120 binding to cadherin. …”
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    α-Catenin contributes to the strength of E-cadherin–p120 interactions
  6. 46
    “…The VH1-2 restricted VRC01-class of antibodies targeting the HIV envelope CD4 binding site are a major focus of HIV vaccine strategies. …”
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    Rapid and Focused Maturation of a VRC01-Class HIV Broadly Neutralizing Antibody Lineage Involves Both Binding and Accommodation of the N276-Glycan
  7. 47
    “…These results demonstrate that both the straight and bent CDRH3 classes of HCV bNAb can be elicited in a single individual, revealing a structural plasticity of VH1-69-derived bNAbs.…”
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    An ultralong CDRH2 in HCV neutralizing antibody demonstrates structural plasticity of antibodies against E2 glycoprotein
  8. 48
    “…Yeast VH1-related phosphatase (YVH1) (also known as DUSP12) is a member of the atypical dual-specificity phosphatase subfamily. …”
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    Src-mediated phosphorylation of the ribosome biogenesis factor hYVH1 affects its localization, promoting partitioning to the 60S ribosomal subunit
  9. 49
    “…Nine of the nAbs employ the germline gene VH1-69, and all seem to use the same neutralizing mechanism. …”
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    Structural and functional bases for broad-spectrum neutralization of avian and human influenza A viruses
  10. 50
    “…In contrast to RA, neither VH6 genes nor the autoimmunity-prone VH4-34 were seen, whereas another autoimmunity-prone gene, V3-23, was predominantly used (11%). One VH1-derived and one VH3-derived B cell clone were expanded. …”
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    B lymphocyte involvement in ankylosing spondylitis: the heavy chain variable segment gene repertoire of B lymphocytes from germinal center-like foci in the synovial membrane indicates antigen selection
  11. 51
    “…We investigated the interactions of peptide substrates with select DUSPs of four types: MAP kinases (DUSP1 and DUSP7), atypical (DUSP3, DUSP14, DUSP22 and DUSP27), viral (variola VH1), and Cdc25 (A-C). Phosphatase recognition sites were experimentally determined by measuring dephosphorylation of 6,218 microarrayed Tyr(P) peptides representing confirmed and theoretical phosphorylation motifs from the cellular proteome. …”
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    Phosphotyrosine Substrate Sequence Motifs for Dual Specificity Phosphatases
  12. 52
    “…Among the 36 PTP genes, ptp-h, which was proposed to be the origin of baculovirus ptp belongs to atypical VH1-like dual-specific PTP subset and encodes a catalytic active protein. …”
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    Characterization of a protein tyrosine phosphatase as a host factor promoting baculovirus replication in silkworm, Bombyx mori
  13. 53
    “…Four-hundred and twenty-nine V(H)DJ(H) rearrangement sequences were analyzed; podocyte-derived Igs exhibited classic V(H)DJ(H) rearrangements with nucleotide additions and somatic hypermutations, biased VH1 usage and restricted diversity. Moreover, compared with the podocytes from healthy control that usually expressed one class of Ig and one V(H)DJ(H) pattern, podocytes from patients expressed more classes of Ig, V(H)DJ(H) patterns and somatic hypermutations. …”
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    Single-Cell Sequencing Confirms Transcripts and V(H)DJ(H) Rearrangements of Immunoglobulin Genes in Human Podocytes
  14. 54
    por Corpe, Louie
    Publicado 2018
    “…The signal strength is measured separately for: fermionic and bosonic production modes, giving $ \hat{\mu}_{{VBF},{VH}} = 1.00^{+0.10}_{-0.10}$ and $\hat{\mu}_{{ggH},{ttH}} = 1.00^{+0.10}_{-0.10}$; and for the ggH, VBF and ttH production modes, giving $\hat{\mu}_{{ggH}} = 0.73^{+0.24}_{-0.22}$, $\hat{\mu}_{{VBF}} = 1.45^{+0.8}_{-0.7}$, and $\hat{\mu}_{{ttH}} = 1.75^{+1.4}_{-1.1}$. …”
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    Study of Higgs boson production through its decay to two photons using data collected at a centre-of-mass energy of 13 TeV with the CMS detector
  15. 55
    “…The 17 V(H) germline genes used by the hybridoma anti-RhD IgG were derived from 4 VH families (VH1, VH2, VH3 and VH4). Eighteen kappa chains were restricted to only 5 germline genes from only 2 Vκ families (Vκ1 and κ3). …”
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    Comparison between Hybridoma and Fab/phage Anti-RhD: Their V Gene Usage and Pairings
  16. 56
    “…The VRC01-class bNAb family derived from the VH1-2*02 germline allele arose in multiple HIV-1–infected donors, yet targets the CD4-binding site on Env with common interactions. …”
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    Structural basis for germline antibody recognition of HIV-1 immunogens
  17. 57
    “…During virus infection C6 reduces ISRE-dependent gene expression despite the presence of the viral protein phosphatase VH1 that dephosphorylates STAT1 and STAT2. The ability of a cytoplasmic replicating virus to dampen the immune response within the nucleus, and the ability of viral immunomodulators such as C6 to inhibit multiple stages of the innate immune response by distinct mechanisms, emphasizes the intricacies of host-pathogen interactions and viral immune evasion.…”
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    Vaccinia Virus Protein C6 Inhibits Type I IFN Signalling in the Nucleus and Binds to the Transactivation Domain of STAT2
  18. 58
    “…Data obtained from an analysis of 60 spontaneously produced anti-DNA antibody VH domain sequences supported our hypothesis only for antibodies, which use V gene segment in germline configuration, such as S57(VH31), MRL-DNA22, and VH11, members of the VH1 (J558) and VH7 (S107) gene families. The important finding is that out of seven V gene segments used by spontaneous anti-DNA antibodies, F(0.367) is only expressed by the germline configuration of these three V gene segments. …”
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    Antibody Epitope Specificity for dsDNA Phosphate Backbone Is an Intrinsic Property of the Heavy Chain Variable Germline Gene Segment Used
  19. 59
    “…The regression equations were Da = 0.6673Va + 11.28 and Dh = 1.009Vh + 1.003. There are statistical significant differences between Dh and Vh, and between Da and Va in those whose Va < 34.96 mm. …”
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    Feasibility of total en-bloc spondylectomy on L5 by a posterior-only approach: An autopsy study
  20. 60
    “…The proteins such as RFX1, TAF10, and VH1 were differently expressed between three breeds. …”
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    Screening of immune biomarkers in different breeds of chickens infected with J subgroup of avian leukemia virus by proteomic
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