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  1. 121
    “…Here we report that the Caenorhabditis elegans orthologues of Van Gogh (vang-1), Prickle (prkl-1), and Dishevelled (dsh-1), core components of planar cell polarity (PCP) signaling, are required in a subset of peripheral motor neurons to restrict neurite emergence to a specific organ axis. …”
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    VANG-1 and PRKL-1 Cooperate to Negatively Regulate Neurite Formation in Caenorhabditis elegans
  2. 122
    “…Van Gogh-like (Vangl) and Prickle (Pk) are core components of the non-canonical Wnt planar cell polarity pathway that controls epithelial polarity and cell migration. …”
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    The planar cell polarity protein VANG-1/Vangl negatively regulates Wnt/β-catenin signaling through a Dvl dependent mechanism
  3. 123
    “…Here, we found that Van Gogh–like 2 (VANGL2) acts as an IFN-inducible negative feedback regulator to suppress IFN-I signaling during vesicular stomatitis virus (VSV) infection. …”
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    VANGL2 inhibits antiviral IFN-I signaling by targeting TBK1 for autophagic degradation
  4. 124
    “…Here by removing both Vangl1 and Vangl2, the two mouse homologues of a Drosophila core planar cell polarity (PCP) gene Van Gogh (Vang), we have uncovered a previously unappreciated function of PCP in initial breaking of lateral symmetry. …”
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    Planar cell polarity breaks the bilateral symmetry by controlling ciliary positioning
  5. 125
    “…Although the vertebrate regulator of planar cell polarity Van Gogh-like 2 (Vangl2) was recently described as a postsynaptic molecule with a PDZ-binding motif, the role of its PDZ interaction at the synapse is unknown. …”
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    PDZ interaction of Vangl2 links PSD-95 and Prickle2 but plays only a limited role in the synaptic localisation of Vangl2
  6. 126
    “…Myo1D controls the orientation of LRO cilia and interacts functionally with the planar cell polarity (PCP) pathway component VanGogh-like2 (Vangl2), to shape a productive LRO flow. …”
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    Myosin1D is an evolutionarily conserved regulator of animal left–right asymmetry
  7. 127
    “…The group of Nab2-regulated brain proteins, identified by quantitative proteomic analysis, includes the microtubule-binding protein Futsch, the neuronal Ig-family transmembrane protein turtle, the glial:neuron adhesion protein contactin, the Rac GTPase-activating protein tumbleweed, and the planar cell polarity factor Van Gogh, which collectively link Nab2 to the processes of brain morphogenesis, neuroblast proliferation, circadian sleep/wake cycles, and synaptic development. …”
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    The RNA-binding protein Nab2 regulates the proteome of the developing Drosophila brain
  8. 128
    “…Membrane presentation of PCP complexes containing Van Gogh-like (VANGL) transmembrane proteins is central to PCP and can be directed by the scaffold protein scribble (SCRIB). …”
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    An interaction between OTULIN and SCRIB uncovers roles for linear ubiquitination in planar cell polarity
  9. 129
    “…Here, we describe a novel role of VANG-1, the only C. elegans ortholog of the conserved PCP component Strabismus/Van Gogh. We show that two alleles of vang-1 and depletion of the protein by RNAi cause an increase of mean life span up to 40%. …”
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    C. elegans VANG-1 Modulates Life Span via Insulin/IGF-1-Like Signaling
  10. 130
    “…BACKGROUND: Van Gogh-like (Vangl) 2 is a planar cell polarity (PCP) protein that regulates the induction of polarized cellular and tissue morphology during animal development. …”
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    The planar cell polarity protein Vangl2 bidirectionally regulates dendritic branching in cultured hippocampal neurons
  11. 131
    “…Heterozygous loop-tail mutation of the core PCP component van Gogh-like 2 (Vangl2) in mouse osteoblasts impairs the orientation of division in response to strain. …”
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    Planar Cell Polarity Aligns Osteoblast Division in Response to Substrate Strain
  12. 132
    “…Furthermore, planar cell polarity (PCP) is conferred by PCP proteins such as Van Gogh-like 2 (Vangl2) in the testis. On the other hand, cell junctions at the Sertoli cell–spermatid (steps 8–19) interface are exclusively supported by adhesion protein complexes (for example, α6β1-integrin-laminin-α3,β3,γ3 and nectin-3-afadin) at the actin-rich apical ectoplasmic specialization (ES) since the apical ES is the only anchoring device in step 8–19 spermatids. …”
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    Cell polarity, cell adhesion, and spermatogenesis: role of cytoskeletons
  13. 133
    “…We also discovered  that spermatid PCP was regulated by PCP protein Vangl2 (Van Gogh-like protein 2) since Vangl2 knockdown by RNAi was found to perturb spermatid PCP. …”
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    Vangl2 regulates spermatid planar cell polarity through microtubule (MT)-based cytoskeleton in the rat testis
  14. 134
    “…Planar cell polarity (PCP) pathways control the orientation and alignment of epithelial cells within tissues. Van Gogh‐like 2 (Vangl2) is a key PCP protein that is required for the normal differentiation of kidney glomeruli and tubules. …”
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    Vangl2, a planar cell polarity molecule, is implicated in irreversible and reversible kidney glomerular injury
  15. 135
    “…Prickle2 levels were negatively regulated by a physical interaction with another PCP protein, Van Gogh-like 2 (Vangl2). The Vangl2-mediated reduction in Prickle2 levels was, at least in part, relieved by proteasome inhibitors or by functional inhibition of the Cullin-1 E3 ubiquitin ligase. …”
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    Vangl2 interaction plays a role in the proteasomal degradation of Prickle2
  16. 136
    “…In the present study, we show Van gogh-like 2 (Vangl2) in early and recycling endosomes as made evident by colocalization with diverse endosomal Rab proteins. …”
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    Adaptor protein-3 complex is required for Vangl2 trafficking and planar cell polarity of the inner ear
  17. 137
    “…There is limited evidence of genetic contribution to specific organ involvement in SLE.(1)(,)(2) We identify a large deletion in intron 7 of Van Gogh Like 1 (VANGL1), which associates with nephritis in SLE patients. …”
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    Deletions in VANGL1 are a risk factor for antibody-mediated kidney disease
  18. 138
    “…The colors in the post-impressionist paintings of Van Gogh and Gauguin is contrasted, and experiments on psychological factors and color research is conducted. …”
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    Visual performance of painting colors based on psychological factors
  19. 139
    “…The first 8 E descendants form a plane of four right cells and four left cells; the plane arises through oriented cell divisions and VANG-1/Van Gogh-dependent repositioning of any non-planar cells. …”
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    Morphogenesis of the C. elegans Intestine Involves Axon Guidance Genes
  20. 140
    “…The ‘core’ PCP pathway involves the asymmetric localization of two distinct membrane-bound complexes, one containing Frizzled (Fz, required in R3) and the other Van Gogh (Vang, required in R4). Inhibitory interactions between the cytosolic components of each complex reinforce asymmetric localization. …”
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    Prickle is phosphorylated by Nemo and targeted for degradation to maintain Prickle/Spiny-legs isoform balance during planar cell polarity establishment
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