“…Our results provide insight into the interplay between opposing regulatory proteins that govern antibiotic production in S. venezuelae, which could be exploited to maximize the production of bioactive natural products in other systems.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Amela and Verse are two Streptomyces phages isolated by enrichment on Streptomyces venezuelae (ATCC 10712) from two different soil samples. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Likewise, disruption of rimP-SV of Streptomyces venezuelae also significantly stimulated jadomycin production, suggesting that enhanced antibiotics production might be widespread in many other Streptomyces species. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Collections of Coryphopterus venezuelae at depths of 65–69 m extend the depth range of that species by approximately 50 m. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In response to this low-iron environment, Streptomyces venezuelae secretes a suite of differentially modified siderophores and upregulates genes associated with siderophore uptake. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…We developed a general method to detect cellular small molecule-RNA conjugates that does not rely on the reactivity of the small molecule, revealing NAD-linked RNA in E. coli and S. venezuelae. Subsequent characterization shows NAD is a 5’ modification of RNA, cannot be installed in vitro through aberrant transcriptional initiation, is only found among smaller cellular RNAs, and is present at a surprisingly high abundance of ~3000 copies per cell.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…CONCLUSIONS: Heterologous expression of vanY(n) from Nonomuraea sp. ATCC 39727 in S. venezuelae was successfully achieved and conferred the host an increased level of glycopeptide resistance. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…However, disruption of this site, which is conserved in the Streptomyces venezuelae GlgE enzyme, did not affect the growth of S. venezuelae or the structure of the polymeric product. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Here, we have FLAG-tagged all 10 c-di-GMP turnover proteins in Streptomyces venezuelae and characterized their expression patterns throughout the life cycle, revealing that the diguanylate cyclase (DGC) CdgB and the phosphodiesterase (PDE) RmdB are the most abundant GGDEF/EAL proteins. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…RESULTS: Using a comparative RNA sequencing analysis of three divergent model streptomycetes (S. coelicolor, S. avermitilis and S. venezuelae), we discovered hundreds of novel cis-antisense RNAs and intergenic small RNAs (sRNAs). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Furthermore, a cumate inducible system was developed for precise temporal control of the ECF17 transcription system in S. venezuelae ISP5230. Theoretically, the switchable ECF17 transcription system could reduce the unwanted influences from host and alleviate the burdens introduced by overexpression of heterologous genes. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Farnesyl diphosphate (FPP) and all fifteen positional isomers of ((13)C(1))FPP were enzymatically converted by the bacterial terpene cyclases corvol ether synthase from Kitasatospora setae, the epi-cubebol synthase from Streptosporangium roseum, and the isodauc-8-en-11-ol synthase from Streptomyces venezuelae. The enzyme products were analysed by GC–MS and GC–QTOF MS(2) and the obtained data were used to delineate the EIMS fragmentation mechanisms of the two sesquiterpene ethers corvol ethers A and B, and the sesquiterpene alcohols epi-cubebol and isodauc-8-en-11-ol.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Four promoters were used in a plug-and-play platform to control the expression of the cryptic cluster of jadomycin B in S. venezuelae ISP5230 and resulted in different levels of the production of jadomycin B that corresponded to promoter strength. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Previously, we reported that a bacterial metabolite produced by Streptomyces venezuelae caused age- and dose-dependent DA neurodegeneration in Caenorhabditis elegans and human SH-SY5Y neurons. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The attB site from Streptomyces venezuelae was used efficiently by an integrating plasmid, pCMF92, constructed using the ϕJoe int-attP locus. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In nature, l-PAPA occurs as an intermediate of the chloramphenicol biosynthesis pathway in Streptomyces venezuelae. Here we demonstrate that the model organism Escherichia coli can be transformed with metabolic grafting approaches to result in an improved l-PAPA producing strain. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Finally, we highlight the current view on the role of the second messenger c-di-AMP in cell differentiation and the osmotic stress responses with specific emphasis on the two models, S. coelicolor and S. venezuelae.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Chloramphenicol (CAM), the bacteriostatic broad-spectrum antibiotic, isolated from Streptomyces venezuelae during the “golden era” of antibiotic discovery, nowadays has limited clinical potential due to adverse side effects and frequent antimicrobial resistance. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Here we show that SepX, an actinobacterial-specific protein, is crucial for both cell division modes in Streptomyces venezuelae. Importantly, we find that sepX-deficient mutants grow without cross-walls and that this substantially impairs the fitness of colonies and the coordinated progression through the developmental life cycle. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Here we show that limited cell damage, either mechanical or enzymatic, leads to near complete destruction of mycelial microcolonies of a Streptomyces venezuelae ftsZ mutant. This result is consistent with a lack of ftsZ-dependent cross-walls and may be inconsistent with a recently proposed role for membrane structures in the proliferation of ftsZ mutants in other Streptomyces species. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso