CRISPR-Cas12–based detection of SARS-CoV-2

por Broughton, James P., Deng, Xianding, Yu, Guixia, Fasching, Clare L., Servellita, Venice, Singh, Jasmeet, Miao, Xin, Streithorst, Jessica, Granados, Andrea, Sotomayor-Gonzalez, Alicia, Zorn, Kelsey, Gopez, Allan, Hsu, Elaine, Gu, Wei, Miller, Steve, Pan, Chao-Yang, Guevara, Hugo, Wadford, Debra A., Chen, Janice S., Chiu, Charles Y.
Publicado 2020

The B.1.427/1.429 (epsilon) SARS-CoV-2 variants are more virulent than ancestral B.1 (614G) in Syrian hamsters

por Carroll, Timothy, Fox, Douglas, van Doremalen, Neeltje, Ball, Erin, Morris, Mary Kate, Sotomayor-Gonzalez, Alicia, Servellita, Venice, Rustagi, Arjun, Yinda, Claude Kwe, Fritts, Linda, Port, Julia Rebecca, Ma, Zhong-Min, Holbrook, Myndi, Schulz, Jonathan, Blish, Catherine A., Hanson, Carl, Chiu, Charles Y., Munster, Vincent, Stanley, Sarah, Miller, Christopher J.
Publicado 2021

Oral prodrug of remdesivir parent GS-441524 is efficacious against SARS-CoV-2 in ferrets

por Cox, Robert M., Wolf, Josef D., Lieber, Carolin M., Sourimant, Julien, Lin, Michelle J., Babusis, Darius, DuPont, Venice, Chan, Julie, Barrett, Kim T., Lye, Diane, Kalla, Rao, Chun, Kwon, Mackman, Richard L., Ye, Chengjin, Cihlar, Tomas, Martinez-Sobrido, Luis, Greninger, Alexander L., Bilello, John P., Plemper, Richard K.
Publicado 2021

Epidermal LysM receptor ensures robust symbiotic signalling in Lotus japonicus

por Murakami, Eiichi, Cheng, Jeryl, Gysel, Kira, Bozsoki, Zoltan, Kawaharada, Yasuyuki, Hjuler, Christian Toftegaard, Sørensen, Kasper Kildegaard, Tao, Ke, Kelly, Simon, Venice, Francesco, Genre, Andrea, Thygesen, Mikkel Boas, de Jong, Noor, Vinther, Maria, Jensen, Dorthe Bødker, Jensen, Knud Jørgen, Blaise, Michael, Madsen, Lene Heegaard, Andersen, Kasper Røjkjær, Stougaard, Jens, Radutoiu, Simona
Publicado 2018

The B.1.427/1.429 (epsilon) SARS-CoV-2 variants are more virulent than ancestral B.1 (614G) in Syrian hamsters

por Carroll, Timothy, Fox, Douglas, van Doremalen, Neeltje, Ball, Erin, Morris, Mary Kate, Sotomayor-Gonzalez, Alicia, Servellita, Venice, Rustagi, Arjun, Yinda, Claude Kwe, Fritts, Linda, Port, Julia Rebecca, Ma, Zhong-Min, Holbrook, Myndi G., Schulz, Jonathan, Blish, Catherine A., Hanson, Carl, Chiu, Charles Y., Munster, Vincent, Stanley, Sarah, Miller, Christopher J.
Publicado 2022

539. Efficacy in Multiple SARS-CoV-2 Animal Models Supports Phase 3 Dose Selection for Obeldesivir

por Pitts, Jared, Babusis, Darius, Humeniuk, Rita, Martinez, David, Cox, Robert M, Schäfer, Alexandra, Riola, Nicholas C, Feng, Joy, Du Pont, Venice, Anoshchenko, Olena, Vermillion, Meghan, Abdelghany, Mazin, Hyland, Robert H, Girish, Sandhya, Sheahan, Timothy P, Plemper, Richard K, Baric, Ralph S, Cihlar, Tomas, Llewellyn, Joe, Winter, Helen, Bannister, Roy, Subramanian, Raju, Mackman, Richard L, Bilello, John P
Publicado 2023

Therapeutic efficacy of an oral nucleoside analog of remdesivir against SARS-CoV-2 pathogenesis in mice.

por Schäfer, Alexandra, Martinez, David R., Won, John J., Moreira, Fernando R., Brown, Ariane J., Gully, Kendra L., Kalla, Rao, Chun, Kwon, Du Pont, Venice, Babusis, Darius, Tang, Jennifer, Murakami, Eisuke, Subramanian, Raju, Barrett, Kimberly T, Bleier, Blake J., Bannister, Roy, Feng, Joy Y., Bilello, John P., Cihlar, Tomas, Mackman, Richard L., Montgomery, Stephanie A., Baric, Ralph S., Sheahan, Timothy P.
Publicado 2021

Neutralizing immunity in vaccine breakthrough infections from the SARS-CoV-2 Omicron and Delta variants

por Servellita, Venice, Syed, Abdullah M., Morris, Mary Kate, Brazer, Noah, Saldhi, Prachi, Garcia-Knight, Miguel, Sreekumar, Bharath, Khalid, Mir M., Ciling, Alison, Chen, Pei-Yi, Kumar, G. Renuka, Gliwa, Amelia S., Nguyen, Jenny, Sotomayor-Gonzalez, Alicia, Zhang, Yueyuan, Frias, Edwin, Prostko, John, Hackett, John, Andino, Raul, Wadford, Debra A., Hanson, Carl, Doudna, Jennifer, Ott, Melanie, Chiu, Charles Y.
Publicado 2022

Detection of SARS-CoV-2 variants by Abbott molecular, antigen, and serological tests

por Rodgers, Mary A, Olivo, Ana, Harris, Barbara J, Lark, Chris, Luo, Xinxin, Berg, Michael G, Meyer, Todd V, Mohaimani, Aurash, Orf, Gregory S, Goldstein, Yitz, Fox, Amy S, Hirschhorn, Julie, Glen, William B, Nolte, Frederick, Landay, Alan, Jennings, Cheryl, Moy, James, Servellita, Venice, Chiu, Charles, Batra, Rahul, Snell, Luke B, Nebbia, Gaia, Douthwaite, Sam, Tanuri, Amilcar, Singh, Lavanya, de Oliveira, Tulio, Ahouidi, Ambroise, Mboup, Souleymane, Cloherty, Gavin A
Publicado 2022

Nucleic acid biomarkers of immune response and cell and tissue damage in children with COVID-19 and MIS-C

por Loy, Conor J., Sotomayor-Gonzalez, Alicia, Servellita, Venice, Nguyen, Jenny, Lenz, Joan, Bhattacharya, Sanchita, Williams, Meagan E., Cheng, Alexandre P., Bliss, Andrew, Saldhi, Prachi, Brazer, Noah, Streithorst, Jessica, Suslovic, William, Hsieh, Charlotte J., Bahar, Burak, Wood, Nathan, Foresythe, Abiodun, Gliwa, Amelia, Bhakta, Kushmita, Perez, Maria A., Hussaini, Laila, Anderson, Evan J., Chahroudi, Ann, Delaney, Meghan, Butte, Atul J., DeBiasi, Roberta L., Rostad, Christina A., De Vlaminck, Iwijn, Chiu, Charles Y.
Publicado 2023

SARS-CoV-2 Spike triggers barrier dysfunction and vascular leak via integrins and TGF-β signaling

por Biering, Scott B., de Sousa, Francielle Tramontini Gomes, Tjang, Laurentia V., Pahmeier, Felix, Ruan, Richard, Blanc, Sophie F., Patel, Trishna S., Worthington, Caroline M., Glasner, Dustin R., Castillo-Rojas, Bryan, Servellita, Venice, Lo, Nicholas T.N., Wong, Marcus P., Warnes, Colin M., Sandoval, Daniel R., Clausen, Thomas Mandel, Santos, Yale A., Ortega, Victoria, Aguilar, Hector C., Esko, Jeffrey D., Chui, Charles Y., Pak, John E., Beatty, P. Robert, Harris, Eva
Publicado 2021

Therapeutic treatment with an oral prodrug of the remdesivir parental nucleoside is protective against SARS-CoV-2 pathogenesis in mice

por Schäfer, Alexandra, Martinez, David R., Won, John J., Meganck, Rita M., Moreira, Fernando R., Brown, Ariane J., Gully, Kendra L., Zweigart, Mark R., Conrad, William S., May, Samantha R., Dong, Stephanie, Kalla, Rao, Chun, Kwon, Du Pont, Venice, Babusis, Darius, Tang, Jennifer, Murakami, Eisuke, Subramanian, Raju, Barrett, Kimberly T., Bleier, Blake J., Bannister, Roy, Feng, Joy Y., Bilello, John P., Cihlar, Tomas, Mackman, Richard L., Montgomery, Stephanie A., Baric, Ralph S., Sheahan, Timothy P.
Publicado 2022

Previous exposure to Spike-providing parental strains confers neutralizing immunity to XBB lineage and other SARS-CoV-2 recombinants in the context of vaccination

por Suryawanshi, Rahul K., Taha, Taha Y., McCavitt-Malvido, Maria, Silva, Ines, Khalid, Mir M., Syed, Abdullah M., Chen, Irene P., Saldhi, Prachi, Sreekumar, Bharath, Montano, Mauricio, Foresythe, Kafaya, Tabata, Takako, Kumar, G. Renuka, Sotomayor-Gonzalez, Alicia, Servellita, Venice, Gliwa, Amelia, Nguyen, Jenny, Kojima, Noah, Arellanor, Teresa, Bussanich, Aallyah, Hess, Victoria, Shacreaw, Maria, Lopez, Lauren, Brobeck, Matthew, Turner, Fred, Wang, Yuzhu, Ghazarian, Sydney, Davis, Gregg, Rodriguez, Diviana, Doudna, Jennifer, Spraggon, Lee, Chiu, Charles Y., Ott, Melanie
Publicado 2023

Remdesivir Inhibits SARS-CoV-2 in Human Lung Cells and Chimeric SARS-CoV Expressing the SARS-CoV-2 RNA Polymerase in Mice

por Pruijssers, Andrea J., George, Amelia S., Schäfer, Alexandra, Leist, Sarah R., Gralinksi, Lisa E., Dinnon, Kenneth H., Yount, Boyd L., Agostini, Maria L., Stevens, Laura J., Chappell, James D., Lu, Xiaotao, Hughes, Tia M., Gully, Kendra, Martinez, David R., Brown, Ariane J., Graham, Rachel L., Perry, Jason K., Du Pont, Venice, Pitts, Jared, Ma, Bin, Babusis, Darius, Murakami, Eisuke, Feng, Joy Y., Bilello, John P., Porter, Danielle P., Cihlar, Tomas, Baric, Ralph S., Denison, Mark R., Sheahan, Timothy P.
Publicado 2020

A diagnostic host response biosignature for COVID-19 from RNA profiling of nasal swabs and blood

por Ng, Dianna L., Granados, Andrea C., Santos, Yale A., Servellita, Venice, Goldgof, Gregory M., Meydan, Cem, Sotomayor-Gonzalez, Alicia, Levine, Andrew G., Balcerek, Joanna, Han, Lucy M., Akagi, Naomi, Truong, Kent, Neumann, Neil M., Nguyen, David N., Bapat, Sagar P., Cheng, Jing, Martin, Claudia Sanchez-San, Federman, Scot, Foox, Jonathan, Gopez, Allan, Li, Tony, Chan, Ray, Chu, Cynthia S., Wabl, Chiara A., Gliwa, Amelia S., Reyes, Kevin, Pan, Chao-Yang, Guevara, Hugo, Wadford, Debra, Miller, Steve, Mason, Christopher E., Chiu, Charles Y.
Publicado 2021

SARS-CoV-2 Spike triggers barrier dysfunction and vascular leak via integrins and TGF-β signaling

por Biering, Scott B., Gomes de Sousa, Francielle Tramontini, Tjang, Laurentia V., Pahmeier, Felix, Zhu, Chi, Ruan, Richard, Blanc, Sophie F., Patel, Trishna S., Worthington, Caroline M., Glasner, Dustin R., Castillo-Rojas, Bryan, Servellita, Venice, Lo, Nicholas T. N., Wong, Marcus P., Warnes, Colin M., Sandoval, Daniel R., Clausen, Thomas Mandel, Santos, Yale A., Fox, Douglas M., Ortega, Victoria, Näär, Anders M., Baric, Ralph S., Stanley, Sarah A., Aguilar, Hector C., Esko, Jeffrey D., Chiu, Charles Y., Pak, John E., Beatty, P. Robert, Harris, Eva
Publicado 2022

Infectious viral shedding of SARS-CoV-2 Delta following vaccination: A longitudinal cohort study

por Garcia-Knight, Miguel, Anglin, Khamal, Tassetto, Michel, Lu, Scott, Zhang, Amethyst, Goldberg, Sarah A., Catching, Adam, Davidson, Michelle C., Shak, Joshua R., Romero, Mariela, Pineda-Ramirez, Jesus, Diaz-Sanchez, Ruth, Rugart, Paulina, Donohue, Kevin, Massachi, Jonathan, Sans, Hannah M., Djomaleu, Manuella, Mathur, Sujata, Servellita, Venice, McIlwain, David, Gaudiliere, Brice, Chen, Jessica, Martinez, Enrique O., Tavs, Jacqueline M., Bronstone, Grace, Weiss, Jacob, Watson, John T., Briggs-Hagen, Melissa, Abedi, Glen R., Rutherford, George W., Deeks, Steven G., Chiu, Charles, Saydah, Sharon, Peluso, Michael J., Midgley, Claire M., Martin, Jeffrey N., Andino, Raul, Kelly, J. Daniel
Publicado 2022