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213721por de Campos, Gabriela Yamazaki, Oliveira-Brito, Patrícia Kellen Martins, Guimarães, Júlia Garcia, da Costa, Letícia Serafim, Lazo Chica, Javier Emílio, da Silva, Thiago Aparecido“…Toll-like receptor (TLR) 2 agonists are important immunomodulators favoring a pro-inflammatory response with potential fungicidal activity, and TLR2 agonists have been used as adjuvants in vaccines against infections caused by bacteria or viruses. Therefore, this work aimed to evaluate the immunomodulatory effect of the tripalmitoyl lipopeptide S-glycerol cysteine (Pam3CSK4 or P3C4), a TLR2 agonist, as an adjuvant in the vaccination against C. gattii infection. …”
Publicado 2023
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213722por Alenou, Leo Dilane, Nwane, Philippe, Mbakop, Lili Ranaise, Piameu, Michael, Ekoko, Wolfgang, Mandeng, Stanislas, Bikoy, Elisabeth Ngo, Toto, Jean Claude, Onguina, Hugues, Etang, Josiane“…CONCLUSIONS: The current findings suggest that, in addition to malaria control strategies, vector-borne disease control approaches in Cameroon should include strategies against lymphatic filariasis and Rift Valley fever in rural areas, and against dengue and Zika viruses in urban areas. GRAPHICAL ABSTRACT: [Image: see text]…”
Publicado 2023
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213723por Deliyannis, Georgia, Gherardin, Nicholas A., Wong, Chinn Yi, Grimley, Samantha L., Cooney, James P., Redmond, Samuel J., Ellenberg, Paula, Davidson, Kathryn C., Mordant, Francesca L., Smith, Tim, Gillard, Marianne, Lopez, Ester, McAuley, Julie, Tan, Chee Wah, Wang, Jing J., Zeng, Weiguang, Littlejohn, Mason, Zhou, Runhong, Fuk-Woo Chan, Jasper, Chen, Zhi-wei, Hartwig, Airn E., Bowen, Richard, Mackenzie, Jason M., Vincan, Elizabeth, Torresi, Joseph, Kedzierska, Katherine, Pouton, Colin W., Gordon, Tom P., Wang, Lin-fa, Kent, Stephen J., Wheatley, Adam K., Lewin, Sharon R., Subbarao, Kanta, Chung, Amy W., Pellegrini, Marc, Munro, Trent, Nolan, Terry, Rockman, Steven, Jackson, David C., Purcell, Damian F.J., Godfrey, Dale I.“…However, many challenges remain, including: the emergence of vaccine-resistant mutant viruses, vaccine stability during storage and transport, waning vaccine-induced immunity, and concerns about infrequent adverse events associated with existing vaccines. …”
Publicado 2023
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213724“…Nitazoxanide has powerful antiviral effects and proven efficacy against a range of viruses including SARS and MERS. Dual therapy by combining appropriate doses of these two medications with diverse activities against COVID-19 is expected to be better than monotherapy with hydroxychloroquine. …”
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213725por Marusinec, Rachel, Kurowski, Kathleen M., Amato, Heather K., Saraiva-Garcia, Carlos, Loayza, Fernanda, Salinas, Liseth, Trueba, Gabriel, Graham, Jay P.“…Only 8% of caretakers knew that antibiotics killed bacteria but not viruses, and over a third reported that they “always” give their children antibiotics when the child’s throat hurts (35%). …”
Publicado 2021
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213726por Schroeder, Simon, Pott, Fabian, Niemeyer, Daniela, Veith, Talitha, Richter, Anja, Muth, Doreen, Goffinet, Christine, Müller, Marcel A, Drosten, Christian“…BACKGROUND: The COVID-19 agent, SARS-CoV-2, is conspecific with SARS-CoV, the causal agent of the severe acute respiratory syndrome epidemic in 2002–03. Although the viruses share a completely homologous repertoire of proteins and use the same cellular entry receptor, their transmission efficiencies and pathogenetic traits differ. …”
Publicado 2021
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213727por Lu, Lijuan, Zhong, Huaqing, Xu, Menghua, Su, Liyun, Cao, Lingfeng, Jia, Ran, Xu, Jin“…RESULTS: Among the 804 fecal samples, 8.58% (69/804) of samples were infected with either HAdV or classic HAstV, and five were co-infected with two diarrhea viruses. The overall detection rates of HAdV and classic HAstV were 3.47% (28/804) and 5.22% (42/804), respectively. …”
Publicado 2021
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213728por Naveca, Felipe Gomes, Nascimento, Valdinete, Souza, Victor, Corado, André de Lima, Nascimento, Fernanda, Silva, George, Mejía, Matilde Contreras, Brandão, Maria Júlia, Costa, Ágatha, Duarte, Débora, Pessoa, Karina, Jesus, Michele, Gonçalves, Luciana, Fernandes, Cristiano, Mattos, Tirza, Abdalla, Ligia, Santos, João Hugo, Martins, Alex, Chui, Fabiola Mendonça, Val, Fernando Fonseca, de Melo, Gisely Cardoso, Xavier, Mariana Simão, Sampaio, Vanderson de Souza, Mourão, Maria Paula, Lacerda, Marcus Vinícius, Batista, Érika Lopes Rocha, Magalhães, Alessandro Leonardo Álvares, Dábilla, Nathânia, Pereira, Lucas Carlos Gomes, Vinhal, Fernando, Miyajima, Fabio, Dias, Fernando Braga Stehling, dos Santos, Eduardo Ruback, Coêlho, Danilo, Ferraz, Matheus, Lins, Roberto, Wallau, Gabriel Luz, Delatorre, Edson, Gräf, Tiago, Siqueira, Marilda Mendonça, Resende, Paola Cristina, Bello, Gonzalo“…Our results showed that the answer behind that was a new generation of Gamma-like viruses, which emerged locally carrying mutations that made it more transmissible and more capable of spreading, partially evading prior immunity triggered by natural infections or vaccines. …”
Publicado 2022
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213729“…Homologous to E6AP carboxyl-terminus (HECT)-type E3 ligase performs ubiquitin (Ub)-proteasomal protein degradation via forming a complex with E2∼Ub. Enveloped viruses including SARS-CoV-2 escape from the infected cells by harnessing the E-class vacuolar protein-sorting (ESCRT) machinery and mimic the cellular system through PPAY motif-based linking to HECT Ub ligase activity. …”
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213730por Itson-Zoske, Brandon, Shin, Seung Min, Xu, Hao, Qiu, Chensheng, Fan, Fan, Hogan, Quinn H., Yu, Hongwei“…Two weeks after induction of knee MIA-OA pain, recombinant adeno-associated viruses (AAV)-encoding potent Ca(V)3.2 inhibitory peptide aptamer 2 (Ca(V)3.2iPA2) that have been characterized in our previous study were delivered into the ipsilateral lumbar 4/5 DRG. …”
Publicado 2022
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213731por Chen, Kai, Martens, Yuka A., Meneses, Axel, Ryu, Daniel H., Lu, Wenyan, Raulin, Ana Caroline, Li, Fuyao, Zhao, Jing, Chen, Yixing, Jin, Yunjung, Linares, Cynthia, Goodwin, Marshall, Li, Yonghe, Liu, Chia-Chen, Kanekiyo, Takahisa, Holtzman, David M., Golde, Todd E., Bu, Guojun, Zhao, Na“…We generated adeno-associated viruses (AAVs) that allowed for distinguishing the α-Syn expression versus spread and injected them into the hippocampus of six-month-old Lrp1-nKO mice and the littermate wild type (WT) controls. …”
Publicado 2022
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213732por Gutiérrez, Eileen H. Jeffrey, Riehle, M. A., Walker, K. R., Ernst, K. C., Davidowitz, G.“…BACKGROUND: The Aedes aegypti mosquito is a vector of several viruses including dengue, chikungunya, zika, and yellow fever. …”
Publicado 2022
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213733por Rhee, Soo-Yon, Schapiro, Jonathan M., Saladini, Francesco, Zazzi, Maurizio, Khoo, Saye, Shafer, Robert W.“…BACKGROUND: Doravirine has a unique resistance profile but how this profile might increase its usefulness beyond first-line therapy in persons with susceptible viruses has not been well studied. We sought to determine scenarios in which doravirine would retain activity against isolates from ART-naïve persons with transmitted drug resistance (TDR) and to identify gaps in available doravirine susceptibility data. …”
Publicado 2023
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213734por Li, Weinan, Xie, Lihan, Zhu, Xiaoyun, Yang, Yi, Wang, Linqun, Yang, Min, Li, Hengfei, Li, Xucheng, Yan, Guangjun, Wu, Xiongfei, Zhao, Weijun, Zhang, Jilong, Yang, Gang, Guo, Yufei, Li, Chengyin, Wang, Rui, Shi, Lijun, Xiong, Zhili, Xu, Puming, Kong, Wenwen, Cui, Mengdi, Yang, Xi, Ba, Yuanming“…Background: Patients diagnosed with influenza and upper respiratory tract infections (URTIs) have similar clinical manifestations and biochemical indices and a low detection rate of viral pathogens, mixed infection with diverse respiratory viruses, and targeted antiviral treatment difficulty in the early stage. …”
Publicado 2023
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213735por Vercellino, Marco, Bosa, Chiara, Alteno, Anastasia, Muccio, Francesco, Marasciulo, Stella, Garelli, Paola, Cavalla, Paola“…A possible hypothesis explaining these results could be that SARS-CoV2 is less prone, compared to other viruses, to induce exacerbations of MS disease activity; another possible interpretation of these data might be that DMT is able to effectively suppress the increase of disease activity triggered by SARS-CoV2 infection.…”
Publicado 2023
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213736por Barrera-Illanes, Alberto N., Micieli, María Victoria, Ibáñez-Shimabukuro, Marina, Santini, María Soledad, Martins, Ademir J., Ons, Sheila“…During epidemics of these viruses, pyrethroid insecticides are used for the control of adult mosquitoes. …”
Publicado 2023
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213737por Shope, Timothy R., Chedid, Khalil, Hashikawa, Andrew N., Martin, Emily T., Sieber, Mary Ann, Des Ruisseau, Gabrielle, Williams, John V., Wheeler, Sarah E., Johnson, Monika, Stiegler, Myla, D’Agostino, Helen, Balasubramani, G. K., Yahner, Kristin A., Wang-Erickson, Anna F.“…These findings suggest that current testing and exclusion recommendations for SARS-CoV-2 in CCCs should be aligned with those for other respiratory viruses with similar morbidity and greater transmission to households.…”
Publicado 2023
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213738por Doll, Margaret K, Shakoor, Brianna Levenson, Kimball, Louise E, Crukley, Jeffery, Ozbek, Nina, Blazevic, Rachel L, Mose, Larry, Boonyaratanakornkit, Jim, Stevens-Ayers, Terry L, Cornell, Kevin, Sheppard, Benjamin D, Hampson, Emma, Sharmin, Faria, Goodwin, Benjamin, Dan, Jennifer M, Archie, Tom, O’Connor, Terry, Boeckh, Michael J, Crotty, Shane, Waghmare, Alpana“…DISCLOSURES: Jim Boonyaratanakornkit, MD, PhD, AstraZeneca: Advisor/Consultant|GlaxoSmithKline: Grant/Research Support|IgM Biosciences: Grant/Research Support|IgM Biosciences: Patent on antibodies to respiratory viruses|Vir Biotechnology: Grant/Research Support Michael J. …”
Publicado 2023
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213739por Baba, Hiroaki, Fukuda, Kyohei, Yoshida, Mie, Kitabayashi, Kouichi, Katsushima, Shinjirou, Sonehara, Hiroki, Mizuno, Kazue, Kanamori, Hajime, Tokuda, Koichi, Nakagawa, Atsuhiro, Mizuno, Akira“…BACKGROUND: Monitoring of airborne viruses in the air is a crucial step in the design of appropriate prevention and control measures. …”
Publicado 2023
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213740por DeCuir, Jennifer, Zhu, Yuwei, Gaglani, Manjusha, Ginde, Adit A, Mohr, Nicholas, Gibbs, Kevin, Hager, David, Frosch, Anne, Mohamed, Amira, Johnson, Nicholas, Steingrub, Jay S, Peltan, Ithan, Martin, Emily T, Bender, William, Wilson, Jennifer, Qadir, Nida, Mallow, Christopher, Kwon, Jennie H, Exline, Matthew, Lauring, Adam S, Columbus, Cristie, Vaughn, Ivana, Safdar, Basmah, Chappell, James, Baughman, Adrienne, Womack, Kelsey N, Swan, Sydney A, McMorrow, Meredith L, Self, Wesley, Surie, Diya“…METHODS: Data from the Investigating Respiratory Viruses in the Acutely Ill (IVY) Network were used to conduct a case-control analysis measuring bivalent vaccine effectiveness (VE) against COVID-19–associated hospitalization over time. …”
Publicado 2023
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