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1021“…Since it fully established itself as one of the prevailing economic forces in the 21st century and in the Western world, it produced deep changes in the way in which people work, connect, and live. …”
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1022por Ghimessy, Aron, Radeczky, Peter, Laszlo, Viktoria, Hegedus, Balazs, Renyi-Vamos, Ferenc, Fillinger, Janos, Klepetko, Walter, Lang, Christian, Dome, Balazs, Megyesfalvi, Zsolt“…KRAS mutations are the most frequent gain-of-function alterations in patients with lung adenocarcinoma (LADC) in the Western world. Although they have been identified decades ago, prior efforts to target KRAS signaling with single-agent therapeutic approaches such as farnesyl transferase inhibitors, prenylation inhibition, impairment of KRAS downstream signaling, and synthetic lethality screens have been unsuccessful. …”
Publicado 2020
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1023“…The incidence of esophageal adenocarcinoma has increased at an alarming rate in the Western world and long-term survival remains poor. Current treatment approaches involve a combination of surgery, chemotherapy, and radiotherapy. …”
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1024por Nair, Lekha Madhavan, Krishna, K M Jagathnath, Kumar, Aswin, Mathews, Susan, Joseph, John, James, Francis Vadakkumparambil“…Germ cell tumour of the testis is the most common cancer in young men in the western world. India has the lowest incidence globally, and hence Indian data are sparse. …”
Publicado 2020
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1025“…In view of American %GDPHE and their mortality rates, which were significantly higher than those of the OWC, these results suggests that the U.S. health care system is the least efficient in the Western world.…”
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1026“…An overdose of the widely used analgesic acetaminophen (APAP) is the most common cause of acute liver failure in the western world and hence is a clinically significant problem. …”
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1027por Almeida-Toledano, Laura, Andreu-Fernández, Vicente, Aras-López, Rosa, García-Algar, Óscar, Martínez, Leopoldo, Gómez-Roig, María Dolores“…Fetal alcohol spectrum disorder is the main preventable cause of intellectual disability in the Western world. Although binge drinking is the most studied prenatal alcohol exposure pattern, other types of exposure, such as the Mediterranean, are common in specific geographic areas. …”
Publicado 2021
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1028por Fidelis, Maria Carolina, Stelini, Rafael Fantelli, Staffa, Leonardo Piropo, Moraes, Aparecida Machado de, Magalhães, Renata Ferreira“…BACKGROUND: Non-melanoma skin cancer is the most common type of malignancy in the Western world, and surgical excision is the preferred approach. …”
Publicado 2021
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1029por Jensen, Agnete Witness Praest, Carnaz Simões, Ana Micaela, thor Straten, Per, Holmen Olofsson, Gitte“…However, lifestyle changes in the Western world are causative as well. Exercise is intrinsically associated with what one could call a “healthy life”, and physical activity is associated with a lower risk of various types of cancer. …”
Publicado 2021
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1030por Sawadogo, Adama, Bui-Duc, An Vinh, D'Ostrevy, Nicolas, Camilleri, Lionel, Azarnoush, Kasra“…Introduction: Aortic valve stenosis is the most frequent cardiac valve pathology in the western world. In high-risk patients, conventional aortic valve replacement (C-AVR) carries high rates of morbidity and mortality. …”
Publicado 2021
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1031“…Colorectal cancers (CRCs) remain one of the most common and challenging neoplasia in the Western world. The response rate of immunotherapeutic treatment approaches in a subset of advanced CRCs is remarkable and has sustainably changed treatment regimens. …”
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1032“…Bullous pemphigoid (BP) is the most prevalent autoimmune blistering skin disease in the Western world affecting mainly the elderly population. …”
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1033“…In the absence of reliable biomarkers for its early detection and more effective therapeutic interventions, pancreatic cancer is projected to become the second leading cause of cancer death in the Western world in the next decade. Therefore, it is essential to discover novel therapeutic targets and to develop more effective and pancreatic cancer-specific therapeutic agents. …”
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1034por Depypere, Bernard, Vyncke, Tom, Dhooghe, Nicolas, Claes, Karel, Blondeel, Phillip, Van Landuyt, Koenraad“…A major part in the Western world consists of iatrogenic lymphedema caused by surgery to the lymph nodes of the axilla or groin. …”
Publicado 2021
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1035“…ABSTRACT: To date, the skin remains the most common cancer site among Caucasians in the western world. The complex, layered structure of human skin harbors a heterogenous population of specialized cells. …”
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1036por Wang, Meizi, Ying, Jianhua, Ugbolue, Ukadike Chris, Buchan, Duncan S., Gu, Yaodong, Baker, Julien S.“…(1) Background: Scotland has one of the highest rates of obesity in the Western World, it is well established that poor weight profiles, and particularly abdominal obesity, is strongly associated with Type II diabetes and cardiovascular diseases. …”
Publicado 2021
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1037por Roguljic, Hrvoje, Nincevic, Vjera, Bojanic, Kristina, Kuna, Lucija, Smolic, Robert, Vcev, Aleksandar, Primorac, Dragan, Vceva, Andrijana, Wu, George Y., Smolic, Martina“…Atherosclerosis is a common pathophysiologic mechanism of cardiovascular disease (CVD) development which is the leading cause of mortality in the Western world. Proposed mechanisms of HCV-induced atherosclerosis includes systemic inflammation due to the chronic infection with increased levels of pro-atherogenic cytokines and chemokines. …”
Publicado 2021
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1038por Tan, Sih Min, Lindblom, Runa S. J., Ziemann, Mark, Laskowski, Adrienne, Granata, Cesare, Snelson, Matthew, Thallas-Bonke, Vicki, El-Osta, Assam, Baeza-Garza, Carlos D., Caldwell, Stuart T., Hartley, Richard C., Krieg, Thomas, Cooper, Mark E., Murphy, Michael P., Coughlan, Melinda T.“…Diabetic kidney disease (DKD) remains the number one cause of end-stage renal disease in the western world. In experimental diabetes, mitochondrial dysfunction in the kidney precedes the development of DKD. …”
Publicado 2021
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1039por Smith, Aisling, Molloy, Eleanor, Miletin, Jan, Curley, Anna, Balfe, Joanne, Franklin, Orla, EL-Khuffash, Afif“…Ireland has one of the highest rates of DS in the western world with an incidence of 1:444 live births. …”
Publicado 2020
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1040por Vernia, Filippo, Valvano, Marco, Fabiani, Stefano, Stefanelli, Gianpiero, Longo, Salvatore, Viscido, Angelo, Latella, Giovanni“…ABSTRACT: Colorectal cancer (CRC) is one of the leading causes of cancer-related death in the Western world. Early detection decreases incidence and mortality. …”
Publicado 2021
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