Integrated multiomics analysis identifies molecular landscape perturbations during hyperammonemia in skeletal muscle and myotubes

por Welch, Nicole, Singh, Shashi Shekhar, Kumar, Avinash, Dhruba, Saugato Rahman, Mishra, Saurabh, Sekar, Jinendiran, Bellar, Annette, Attaway, Amy H., Chelluboyina, Aruna, Willard, Belinda B., Li, Ling, Huo, Zhiguang, Karnik, Sadashiva S., Esser, Karyn, Longworth, Michelle S., Shah, Yatrik M., Davuluri, Gangarao, Pal, Ranadip, Dasarathy, Srinivasan
Publicado 2021

Dysregulated cellular redox status during hyperammonemia causes mitochondrial dysfunction and senescence by inhibiting sirtuin‐mediated deacetylation

por Mishra, Saurabh, Welch, Nicole, Karthikeyan, Manikandan, Bellar, Annette, Musich, Ryan, Singh, Shashi Shekhar, Zhang, Dongmei, Sekar, Jinendiran, Attaway, Amy H., Chelluboyina, Aruna Kumar, Lorkowski, Shuhui Wang, Roychowdhury, Sanjoy, Li, Ling, Willard, Belinda, Smith, Jonathan D., Hoppel, Charles L., Vachharajani, Vidula, Kumar, Avinash, Dasarathy, Srinivasan
Publicado 2023

Microglial senescence contributes to female-biased neuroinflammation in the aging mouse hippocampus: implications for Alzheimer’s disease

por Ocañas, Sarah R., Pham, Kevin D., Cox, Jillian E. J., Keck, Alex W., Ko, Sunghwan, Ampadu, Felix A., Porter, Hunter L., Ansere, Victor A., Kulpa, Adam, Kellogg, Collyn M., Machalinski, Adeline H., Thomas, Manu A., Wright, Zsabre, Chucair-Elliott, Ana J., Freeman, Willard M.
Publicado 2023

Quantitative H((2))S-mediated protein sulfhydration reveals metabolic reprogramming during the integrated stress response

por Gao, Xing-Huang, Krokowski, Dawid, Guan, Bo-Jhih, Bederman, Ilya, Majumder, Mithu, Parisien, Marc, Diatchenko, Luda, Kabil, Omer, Willard, Belinda, Banerjee, Ruma, Wang, Benlian, Bebek, Gurkan, Evans, Charles R., Fox, Paul L., Gerson, Stanton L., Hoppel, Charles L., Liu, Ming, Arvan, Peter, Hatzoglou, Maria
Publicado 2015

Immune Checkpoint Molecules on Tumor-Infiltrating Lymphocytes and Their Association with Tertiary Lymphoid Structures in Human Breast Cancer

por Solinas, Cinzia, Garaud, Soizic, De Silva, Pushpamali, Boisson, Anaïs, Van den Eynden, Gert, de Wind, Alexandre, Risso, Paolo, Rodrigues Vitória, Joel, Richard, François, Migliori, Edoardo, Noël, Grégory, Duvillier, Hugues, Craciun, Ligia, Veys, Isabelle, Awada, Ahmad, Detours, Vincent, Larsimont, Denis, Piccart-Gebhart, Martine, Willard-Gallo, Karen
Publicado 2017

Insulin-like growth factor receptor signaling regulates working memory, mitochondrial metabolism, and amyloid-β uptake in astrocytes

por Logan, Sreemathi, Pharaoh, Gavin A., Marlin, M. Caleb, Masser, Dustin R., Matsuzaki, Satoshi, Wronowski, Benjamin, Yeganeh, Alexander, Parks, Eileen E., Premkumar, Pavithra, Farley, Julie A., Owen, Daniel B., Humphries, Kenneth M., Kinter, Michael, Freeman, Willard M., Szweda, Luke I., Van Remmen, Holly, Sonntag, William E.
Publicado 2018

Inflammatory Phenotypes Predict Changes in Arterial Stiffness Following Antiretroviral Therapy Initiation

por Kelly, Christine, Tinago, Willard, Alber, Dagmar, Hunter, Patricia, Luckhurst, Natasha, Connolly, Jake, Arrigoni, Francesca, Abner, Alejandro Garcia, Kamngona, Ralph, Sheha, Irene, Chammudzi, Mishek, Jambo, Kondwani, Mallewa, Jane, Rapala, Alicja, Heyderman, Robert S, Mallon, Patrick W G, Mwandumba, Henry, Walker, A Sarah, Klein, Nigel, Khoo, Saye
Publicado 2020

California's COVID-19 Virtual Training Academy: Rapid Scale-Up of a Statewide Contact Tracing and Case Investigation Workforce Training Program

por Brickley, Debbie B., Forster, Maeve, Alonis, Amelia, Antonyan, Elizabeth, Chen, Lisa, DiGiammarino, Alicia, Dorian, Alina, Dunn, Caitlin, Gandelman, Alice, Grasso, Mike, Kiureghian, Alice, Maher, Andrew D., Malan, Hannah, Mejia, Patricia, Peare, Anna, Prelip, Michael, Shafir, Shira, White, Karen, Willard-Grace, Rachel, Reid, Michael
Publicado 2021

Context dependent effects of ascorbic acid treatment in TET2 mutant myeloid neoplasia

por Guan, Yihong, Greenberg, Edward F., Hasipek, Metis, Chen, Shi, Liu, Xiaochen, Kerr, Cassandra M., Gackowski, Daniel, Zarakowska, Ewelina, Radivoyevitch, Tomas, Gu, Xiaorong, Willard, Belinda, Visconte, Valeria, Makishima, Hideki, Nazha, Aziz, Mukherji, Mridul, Sekeres, Mikkael A., Saunthararajah, Yogen, Oliński, Ryszard, Xu, Mingjiang, Maciejewski, Jaroslaw P., Jha, Babal K.
Publicado 2020

Mitochondrial oxidative stress impairs contractile function but paradoxically increases muscle mass via fibre branching

por Ahn, Bumsoo, Ranjit, Rojina, Premkumar, Pavithra, Pharaoh, Gavin, Piekarz, Katarzyna M., Matsuzaki, Satoshi, Claflin, Dennis R., Riddle, Kaitlyn, Judge, Jennifer, Bhaskaran, Shylesh, Satara Natarajan, Kavithalakshmi, Barboza, Erika, Wronowski, Benjamin, Kinter, Michael, Humphries, Kenneth M., Griffin, Timothy M., Freeman, Willard M., Richardson, Arlan, Brooks, Susan V., Van Remmen, Holly
Publicado 2019

Gods are watching and so what? Moralistic supernatural punishment across 15 cultures

por Bendixen, Theiss, Lightner, Aaron D., Apicella, Coren, Atkinson, Quentin, Bolyanatz, Alexander, Cohen, Emma, Handley, Carla, Henrich, Joseph, Klocová, Eva Kundtová, Lesorogol, Carolyn, Mathew, Sarah, McNamara, Rita A., Moya, Cristina, Norenzayan, Ara, Placek, Caitlyn, Soler, Montserrat, Vardy, Tom, Weigel, Jonathan, Willard, Aiyana K., Xygalatas, Dimitris, Lang, Martin, Purzycki, Benjamin Grant
Publicado 2023

Results from a Beam Test of a Prototype PLT Diamond Pixel Telescope

por Hall-Wilton, Richard, Loos, Robert, Ryjov, Vladimir, Pernicka, Manfred, Schmied, S, Steninger, H, Halyo, Valerie, Harrop, B, Hunt, Adam, Marlow, Daniel, Sands, B, Stickland, David, Atramentov, Oleksiy, Bartz, Ed, Doroshenko, John, Gershtein, Yuri, Hits, Dmitry, Schnetzer, Steve, Stone, Robert, Butler, Philip H, Lansley, Stuart, Rodrigues, N, Bugg, William, Hollingsworth, Matthew, Spanier, Stefan, Johns, Willard
Publicado 2009

A Useful and Sustainable Role for N‐of‐1 Trials in the Healthcare Ecosystem

por Selker, Harry P., Cohen, Theodora, D’Agostino, Ralph B., Dere, Willard H., Ghaemi, S. Nassir, Honig, Peter K., Kaitin, Kenneth I., Kaplan, Heather C., Kravitz, Richard L., Larholt, Kay, McElwee, Newell E., Oye, Kenneth A., Palm, Marisha E., Perfetto, Eleanor, Ramanathan, Chandra, Schmid, Christopher H., Seyfert‐Margolis, Vicki, Trusheim, Mark, Eichler, Hans‐Georg
Publicado 2021

Immune Infiltration in Invasive Lobular Breast Cancer

por Desmedt, Christine, Salgado, Roberto, Fornili, Marco, Pruneri, Giancarlo, Van den Eynden, Gert, Zoppoli, Gabriele, Rothé, Françoise, Buisseret, Laurence, Garaud, Soizic, Willard-Gallo, Karen, Brown, David, Bareche, Yacine, Rouas, Ghizlane, Galant, Christine, Bertucci, François, Loi, Sherene, Viale, Giuseppe, Di Leo, Angelo, Green, Andrew R, Ellis, Ian O, Rakha, Emad A, Larsimont, Denis, Biganzoli, Elia, Sotiriou, Christos
Publicado 2018

Clinical outcomes of a genomic screening program for actionable genetic conditions

por Buchanan, Adam H., Lester Kirchner, H., Schwartz, Marci L. B., Kelly, Melissa A., Schmidlen, Tara, Jones, Laney K., Hallquist, Miranda L. G., Rocha, Heather, Betts, Megan, Schwiter, Rachel, Butry, Loren, Lazzeri, Amanda L., Frisbie, Lauren R., Rahm, Alanna Kulchak, Hao, Jing, Willard, Huntington F., Martin, Christa L., Ledbetter, David H., Williams, Marc S., Sturm, Amy C.
Publicado 2020

A gut microbial metabolite of dietary polyphenols reverses obesity-driven hepatic steatosis

por Osborn, Lucas J., Schultz, Karlee, Massey, William, DeLucia, Beckey, Choucair, Ibrahim, Varadharajan, Venkateshwari, Banerjee, Rakhee, Fung, Kevin, Horak, Anthony J., Orabi, Danny, Nemet, Ina, Nagy, Laura E., Wang, Zeneng, Allende, Daniela S., Willard, Belinda B., Sangwan, Naseer, Hajjar, Adeline M., McDonald, Christine, Ahern, Philip P., Hazen, Stanley L., Brown, J. Mark, Claesen, Jan
Publicado 2022

Novel Phenotypic Outcomes Identified for a Public Collection of Approved Drugs from a Publicly Accessible Panel of Assays

por Lee, Jonathan A., Shinn, Paul, Jaken, Susan, Oliver, Sarah, Willard, Francis S., Heidler, Steven, Peery, Robert B., Oler, Jennifer, Chu, Shaoyou, Southall, Noel, Dexheimer, Thomas S., Smallwood, Jeffrey, Huang, Ruili, Guha, Rajarshi, Jadhav, Ajit, Cox, Karen, Austin, Christopher P., Simeonov, Anton, Sittampalam, G. Sitta, Husain, Saba, Franklin, Natalie, Wild, David J., Yang, Jeremy J., Sutherland, Jeffrey J., Thomas, Craig J.
Publicado 2015

Merestinib (LY2801653) inhibits neurotrophic receptor kinase (NTRK) and suppresses growth of NTRK fusion bearing tumors

por Konicek, Bruce W., Capen, Andrew R., Credille, Kelly M., Ebert, Philip J., Falcon, Beverly L., Heady, Gary L., Patel, Bharvin K.R., Peek, Victoria L., Stephens, Jennifer R., Stewart, Julie A., Stout, Stephanie L., Timm, David E., Um, Suzane L., Willard, Melinda D., Wulur, Isabella H., Zeng, Yi, Wang, Yong, Walgren, Richard A., Betty Yan, Sau-Chi
Publicado 2018

Genomic characterization of intrinsic and acquired resistance to cetuximab in colorectal cancer patients

por Bray, Steven M., Lee, Jeeyun, Kim, Seung Tae, Hur, Joon Young, Ebert, Philip J., Calley, John N., Wulur, Isabella H., Gopalappa, Thejaswini, Wong, Swee Seong, Qian, Hui-Rong, Ting, Jason C., Liu, Jiangang, Willard, Melinda D., Novosiadly, Ruslan D., Park, Young Suk, Park, Joon Oh, Lim, Ho Yeong, Kang, Won Ki, Aggarwal, Amit, Kim, Hee Cheol, Reinhard, Christoph
Publicado 2019

Tirzepatide is an imbalanced and biased dual GIP and GLP-1 receptor agonist

por Willard, Francis S., Douros, Jonathan D., Gabe, Maria B.N., Showalter, Aaron D., Wainscott, David B., Suter, Todd M., Capozzi, Megan E., van der Velden, Wijnand J.C., Stutsman, Cynthia, Cardona, Guemalli R., Urva, Shweta, Emmerson, Paul J., Holst, Jens J., D’Alessio, David A., Coghlan, Matthew P., Rosenkilde, Mette M., Campbell, Jonathan E., Sloop, Kyle W.
Publicado 2020