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  1. 30461
    “…We conducted gene-based tests for rare variants using (1) a sliding-window approach, (2) a selection of functional exonic variants, or (3) all variants. …”
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    Whole genome sequence analyses of brain imaging measures in the Framingham Study
  2. 30462
    “…The main reasons for non-enrolment were the time window for inclusion being after regular working hours (35%, n=23) and oversight (24%, n=16). …”
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    Prognostication in critically ill patients with severe traumatic brain injury: the TBI-Prognosis multicentre feasibility study
  3. 30463
    “…CONCLUSIONS: Prenatal exposure to famine may have long-term effects on declined GFR and the development of CKD in humans. thus, fetal stage may be an important time window to prevent CKD in later life.…”
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    Exposure to famine in early life and chronic kidney diseases in adulthood
  4. 30464
    “…Adult anophelines collected using outdoor clay pots, window exit traps and indoor spray catches were checked for feeding status, blood meal origin and Plasmodium circumsporozoite protein. …”
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    The bionomics of the malaria vector Anopheles rufipes Gough, 1910 and its susceptibility to deltamethrin insecticide in North Cameroon
  5. 30465
    “…Here, we focused on the causal relationship between s-GABA(A)R activity and signal integration in the rat’s dentate gyrus granule cells to find that s-GABA(A)Rs play an important role in neural signal transduction. s-GABA(A)Rs shape the dynamics of phasic inhibitory responses, regulate the action potential generation machinery and control the coincidence detection window pertinent to excitatory input summation. Our results demonstrate that tonic inhibition delivered by s-GABA(A)Rs contributes to the key mechanisms that ensure implementation of neural signal filtering and integration, in a GABA-independent manner. …”
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    Spontaneously opening GABA(A) receptors play a significant role in neuronal signal filtering and integration
  6. 30466
    “…These changes offer a therapeutic window in CML, with intervention using BMP inhibitors in combination with TKI having the potential to target LSC self-renewal and improve long-term outcome for patients.…”
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    Chronic myeloid leukaemia cells require the bone morphogenic protein pathway for cell cycle progression and self-renewal
  7. 30467
    “…Despite the efforts to alter dosing, the therapeutic window remained too narrow to warrant further clinical development. …”
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    Phase Ib study evaluating safety and clinical activity of the anti-HER3 antibody lumretuzumab combined with the anti-HER2 antibody pertuzumab and paclitaxel in HER3-positive, HER2-low metastatic breast cancer
  8. 30468
    “…Signals were filtered, rectified and integrated using a moving sample window. Processed EMG signals (iEMG) from RPNIs were validated against Control and Denervated group outputs. …”
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    Regenerative peripheral nerve interfaces for real-time, proportional control of a Neuroprosthetic hand
  9. 30469
    “…Along with this, since aging has been associated with higher frequency of seizures, prematurely aging mice, simulating human progeroid diseases, offer a further useful modeling element as they recapitulate aging over a short time-window. Here we report on a mouse mutant with progeroid traits that displays repeated spontaneous seizures. …”
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    p53-Sensitive Epileptic Behavior and Inflammation in Ft1 Hypomorphic Mice
  10. 30470
    “…These significant associations were clustered into 446 genomic regions with a window size of 20 Mb per region, and 673 candidate genes containing the significantly associated SNPs were identified. …”
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    Genome-Wide Association Mapping and Genomic Prediction Analyses Reveal the Genetic Architecture of Grain Yield and Flowering Time Under Drought and Heat Stress Conditions in Maize
  11. 30471
    “…Physicians, however, tend to overestimate life expectancy, and miss the window of opportunity to initiate Advance Care Planning. …”
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    Online Artículo Texto
    Predicting life expectancy with a long short-term memory recurrent neural network using electronic medical records
  12. 30472
    “…Initial association hits detected by sliding window were refined (HAPLOVIEW 3.1 and PHASE 2.1) and correlated to homeostasis model assessment (HOMA(IR)) index, in vivo insulin sensitivity (S(I)) and BCAA plasma levels (ANOVA). …”
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    Fine-scale haplotype mapping of MUT, AACS, SLC6A15 and PRKCA genes indicates association with insulin resistance of metabolic syndrome and relationship with branched chain amino acid metabolism or regulation
  13. 30473
    “…INTERVENTIONS: The mobile shield barrier was a custom-made 2 mm Pb shielding plate (width: 120 cm, height: 190 cm) with a 0.5 mm Pb window (width: 115 cm, height: 60 cm) on its upper part was used. …”
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    Radiation protection effect of mobile shield barrier for the medical personnel during endoscopic retrograde cholangiopancreatography: a quasi-experimental prospective study
  14. 30474
    “…Detection of the cancerised field is an encouraging prospect for surveillance, but punctuated evolution may limit the window for early detection.…”
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    Evolutionary history of human colitis-associated colorectal cancer
  15. 30475
    “…The mcr-1-positive E. coli isolates had varied susceptibility profiles, although all three were susceptible to carbapenems. This therapeutic window is crucial given the risk of rapid deterioration in high-incidence areas worldwide.…”
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    Epidemiology and molecular characterization of mcr-1 in Escherichia coli recovered from patients with bloodstream infections in Changsha, central China
  16. 30476
    “…The fruit extract induced severe cardiac hypertrophy in treated embryos. The time window treatment showed that M. charantia perturbed the cardiac myoblast specification process in treated zebrafish embryos. …”
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    Bitter gourd (Momordica charantia) possess developmental toxicity as revealed by screening the seeds and fruit extracts in zebrafish embryos
  17. 30477
    por Sarin, Shiv Kumar, Choudhury, Ashok, Sharma, Manoj K., Maiwall, Rakhi, Al Mahtab, Mamun, Rahman, Salimur, Saigal, Sanjiv, Saraf, Neeraj, Soin, A. S., Devarbhavi, Harshad, Kim, Dong Joon, Dhiman, R. K., Duseja, Ajay, Taneja, Sunil, Eapen, C. E., Goel, Ashish, Ning, Q., Chen, Tao, Ma, Ke, Duan, Z., Yu, Chen, Treeprasertsuk, Sombat, Hamid, S. S., Butt, Amna S., Jafri, Wasim, Shukla, Akash, Saraswat, Vivek, Tan, Soek Siam, Sood, Ajit, Midha, Vandana, Goyal, Omesh, Ghazinyan, Hasmik, Arora, Anil, Hu, Jinhua, Sahu, Manoj, Rao, P. N., Lee, Guan H., Lim, Seng G., Lesmana, Laurentius A., Lesmana, Cosmas Rinaldi, Shah, Samir, Prasad, V. G. Mohan, Payawal, Diana A., Abbas, Zaigham, Dokmeci, A. Kadir, Sollano, Jose D., Carpio, Gian, Shresta, Ananta, Lau, G. K., Fazal Karim, Md., Shiha, Gamal, Gani, Rino, Kalista, Kemal Fariz, Yuen, Man-Fung, Alam, Seema, Khanna, Rajeev, Sood, Vikrant, Lal, Bikrant Bihari, Pamecha, Viniyendra, Jindal, Ankur, Rajan, V., Arora, Vinod, Yokosuka, Osamu, Niriella, Madunil A., Li, Hai, Qi, Xiaolong, Tanaka, Atsushi, Mochida, Satoshi, Chaudhuri, Dominic Ray, Gane, Ed, Win, Khin Maung, Chen, Wei Ting, Rela, Mohd., Kapoor, Dharmesh, Rastogi, Amit, Kale, Pratibha, Rastogi, Archana, Sharma, Chhagan Bihari, Bajpai, Meenu, Singh, Virender, Premkumar, Madhumita, Maharashi, Sudhir, Olithselvan, A., Philips, Cyriac Abby, Srivastava, Anshu, Yachha, Surender K., Wani, Zeeshan Ahmad, Thapa, B. R., Saraya, Anoop, Shalimar, Kumar, Ashish, Wadhawan, Manav, Gupta, Subash, Madan, Kaushal, Sakhuja, Puja, Vij, Vivek, Sharma, Barjesh C., Garg, Hitendra, Garg, Vishal, Kalal, Chetan, Anand, Lovkesh, Vyas, Tanmay, Mathur, Rajan P., Kumar, Guresh, Jain, Priyanka, Pasupuleti, Samba Siva Rao, Chawla, Yogesh K., Chowdhury, Abhijit, Alam, Shahinul, Song, Do Seon, Yang, Jin Mo, Yoon, Eileen L.
    Publicado 2019
    “…The AARC database was also approached for answering some of the issues where published data were limited, such as liver failure grading, its impact on the ‘Golden Therapeutic Window’, extrahepatic organ dysfunction and failure, development of sepsis, distinctive features of acute decompensation from ACLF and pediatric ACLF and the issues were analyzed. …”
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    Acute-on-chronic liver failure: consensus recommendations of the Asian Pacific association for the study of the liver (APASL): an update
  18. 30478
    “…These results demonstrate 2–5 orders of magnitude difference in the selective cytotoxicity towards NSCLCs, reflecting a potentially outstanding therapeutic window. Moreover, the dual utility of aptamer-decorated NPs for both drug stabilization and selective tumor targeting was studied by increasing APT concentrations during NP “decoration”. …”
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    Selective eradication of human non-small cell lung cancer cells using aptamer-decorated nanoparticles harboring a cytotoxic drug cargo
  19. 30479
    “…Conclusions: IL6 may contribute to the risk stratification of patients at major risk for aGvHD and TRM, potentially providing a window for additional prophylactic or preemptive strategies to improve the quality of life in the early post-transplant phase and the outcome of allo-HSCT.…”
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    Interleukin-6 as Biomarker for Acute GvHD and Survival After Allogeneic Transplant With Post-transplant Cyclophosphamide
  20. 30480
    “…In this study we are aiming to validate an experimental model for the induction of uniform temperature elevation in osteolytic bone tumours, using the natural acoustic window provided by the cortical breakthrough. MATERIALS AND METHODS: Experiments were conducted on ex vivo lamb shank by mimicking osteolytic bone tumours. …”
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    Mild hyperthermia by MR-guided focused ultrasound in an ex vivo model of osteolytic bone tumour: optimization of the spatio-temporal control of the delivered temperature
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