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  1. 30721
    “…Therefore, we conclude that (1) at this low frequency, and for the large oscillations, lipid-shelled microbubbles can be approximately modeled as clean gas microbubbles and (2) the development of safe and successful protocols for therapeutic delivery to the brain utilizing 250 kHz or a similar center frequency requires consideration of the narrow pressure window between stable and inertial cavitation.…”
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    Enhanced microbubble contrast agent oscillation following 250 kHz insonation
  2. 30722
    “…CONCLUSIONS: Children (less than 10 years) in rural households are at their highest risk of dying within 6 weeks of mother’s death and this risk decreases substantially after the highly vulnerable window. This indicates that the period of mother’s death does play a critical role on the survival of her children.Thus, understanding this risk and its timing in relation to a mother’s death is critical to guide interventions and stress the relevance of assessing the interaction between clinical care and socio-economic programs in addressing the needs of orphans.…”
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    Effect of timing of mother’s death on child survival in a rural HIV hyper-endemic South African population
  3. 30723
    “…At the same time, the information on such blogs offers a new window into what challenges and successes caregivers experience in helping to manage their children’s T1D. …”
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    A Novel Approach to Identifying Barriers and Facilitators in Raising a Child With Type 1 Diabetes: Qualitative Analysis of Caregiver Blogs
  4. 30724
    “…RESULTS: We propose a new method for the prediction of CaM-binding proteins based on both the total and average scores of known and new SLiMs in protein sequences using a new scoring method called sliding window scoring (SWS) as features for the prediction module. …”
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    The predictive performance of short-linear motif features in the prediction of calmodulin-binding proteins
  5. 30725
    “…As human assisted reproductive technologies (ARTs) occur during the sensitive periconceptional window of development, it has recently become a matter of urgency to investigate risk in ART-conceived children. …”
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    The growth of assisted reproductive treatment-conceived children from birth to 5 years: a national cohort study
  6. 30726
    “…The index date was defined as the date of the first PCSK9i prescription (index claim) during the enrollment window; patients were followed for ≥6 months postindex. …”
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    Treatment patterns and patient characteristics among early initiators of PCSK9 inhibitors
  7. 30727
    “…Photorelease of γ-DGG prior to the stimulus and up to 3 ms after showed strong inhibition similar to steady-state inhibition; in contrast γ-DGG applied by a flash at 3–4 ms post-stimulus produced weaker and variable block, suggesting transmitter-receptor interaction occurs mainly in this time window. The data also show a small and lasting component of inhibition when γ-DGG was released at 4–7 ms post stimulus, near the peak of the CF-PC EPSC, or at 10–11 ms. …”
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    Photolysis of a Caged, Fast-Equilibrating Glutamate Receptor Antagonist, MNI-Caged γ-D-Glutamyl-Glycine, to Investigate Transmitter Dynamics and Receptor Properties at Glutamatergic Synapses
  8. 30728
    “…Patients were determined to have T2DM when two of the following occurred within a 2-year window: physician-entered outpatient T2DM diagnosis (International Classification of Diseases [ICD]-9 250.00; ICD-10 E11), dispensing of an antihyperglycemia agent, and hemoglobin A1c (A1c) >6.5% (48 mmol/mol) or fasting plasma glucose (FPG) >125 mg/dL. …”
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    Insomnia is associated with an increased risk of type 2 diabetes in the clinical setting
  9. 30729
    “…Thus, TWEAK is a promising serum marker of the best window to perform brain MRI, optimizing the disease control in patients.…”
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    High levels of serum soluble TWEAK are associated with neuroinflammation during multiple sclerosis
  10. 30730
    “…Echocardiographic evaluation is often hampered by reduced acoustic window settings. Cardiovascular magnetic resonance (CMR) imaging provides a robust alternative as it allows for comprehensive assessment of degree of AR and LV function. …”
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    Validation of aortic valve 4D flow analysis and myocardial deformation by cardiovascular magnetic resonance in patients after the arterial switch operation
  11. 30731
    “…The preconception period may be a window of opportunity to improve lifestyle, reduce obesity and improve cardiometabolic health. …”
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    Long-term effects of a preconception lifestyle intervention on cardiometabolic health of overweight and obese women
  12. 30732
    “…This preconception period is a unique window of opportunity when women are often more motivated to optimise health and change their lifestyle in preparation for pregnancy. …”
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    Addressing preconception behaviour change through mobile phone apps: a protocol for a systematic review and meta-analysis
  13. 30733
    “…Patients with newly diagnosed stage II/III breast cancer eligible to receive (neo) adjuvant chemotherapy with docetaxel/doxorubicin/cyclophosphamide every 3 weeks for 6 cycles were enrolled and randomized 2:1 to 6 mg of MYL-1401H or reference pegfilgrastim 24 h (+ 2-h window after the first 24 h) after the end of chemotherapy. …”
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    Randomized phase 3 efficacy and safety trial of proposed pegfilgrastim biosimilar MYL-1401H in the prophylactic treatment of chemotherapy-induced neutropenia
  14. 30734
    “…One cycle, also the dose-limiting toxicity (DLT) window, was 21 days. The primary endpoint was to determine the RP2D of weekly ONC201, which was confirmed in an 11-patient dose expansion cohort. …”
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    Safety and enhanced immunostimulatory activity of the DRD2 antagonist ONC201 in advanced solid tumor patients with weekly oral administration
  15. 30735
    “…CONCLUSIONS: This work suggests that the knowledge of such a unique non-dimensional time would allow estimation of the time window at which solute concentration in tissue peaks. …”
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    Mixture theory modeling for characterizing solute transport in breast tumor tissues
  16. 30736
    “…A longer effective treatment window, extended treatment efficacy, and enhanced neuroprotection represent significant advantages of neurosteroids over benzodiazepines. …”
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    Enaminone Modulators of Extrasynaptic α(4)β(3)δ γ-Aminobutyric Acid(A) Receptors Reverse Electrographic Status Epilepticus in the Rat After Acute Organophosphorus Poisoning
  17. 30737
    “…While the use of autologous cells is considered ideal, key challenges for their clinical translation include the ability to reproducibly generate sufficient quantities of cells within a therapeutically relevant time window. METHODS: We performed transfection of three distinct human somatic starting populations of cells with a non-integrating synthetic plasmid expressing Musashi 1 (MSI1), Neurogenin 2 (NGN2), and Methyl-CpG-Binding Domain 2 (MBD2). …”
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    Examining the fundamental biology of a novel population of directly reprogrammed human neural precursor cells
  18. 30738
    “…We compare findings from various mass spectrometry (MS) approaches including quantitative proteomics methods such as stable isotope labeling by amino acids in cell culture (SILAC) and tandem mass tagging (TMT) to approaches such as label-free quantitation (LFQ) and sequential windowed acquisition of all theoretical fragment ion mass spectra (SWATH-MS) in studies of ALS and FTD. …”
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    Proteomics Approaches for Biomarker and Drug Target Discovery in ALS and FTD
  19. 30739
    “…A total of 24 anatomical-region-based models, 231 sliding-window-based models, and 100 random-selection-based models are built. …”
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    Connectome-Based Biomarkers Predict Subclinical Depression and Identify Abnormal Brain Connections With the Lateral Habenula and Thalamus
  20. 30740
    “…Studies evaluating the toxicity of SAH-EJ1 also demonstrate a broad therapeutic window. CONCLUSIONS: Taken together, these data indicate that SAH-EJ1 may be an effective therapeutic for HER-driven cancers with the potential to eliminate triple negative inflammatory breast cancer. …”
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    Stapled EGFR peptide reduces inflammatory breast cancer and inhibits additional HER-driven models of cancer
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