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  1. 31621
    por Ter Hark, S., Vos, N.
    Publicado 2023
    “…TCA dosing is aimed at achieving a concentration in the therapeutic window. Due to inter-individual differences in activity of Cytochrome P450 (CYP) 2D6 and 2C19, (enzymes involved in TCA metabolism) patients require an individualized dose. …”
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    Pharmacogenetics to Personalize Dosing of Tricyclic Antidepressants in Major Depressive Disorder: A Randomized Clinical Trial (PITA study)
  2. 31622
    Publicado 2023
    “…. - Consider the ‘policy window’. - Make the comparison with the policy plan. - Propose an action the politician should undertake. - Identify the relevant stakeholders and groups affected by the problem. …”
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    8.I. Skills building seminar: Improving your elevator pitch: convincing a policymaker in a matter of seconds
  3. 31623
    “…Superior semicircular canal dehiscence (SSCD) is a vestibular-cochlear disorder in humans in which a pathological third mobile window of the otic capsule creates changes to the flow of sound pressure energy through the perilymph/endolymph. …”
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    Superior semicircular canal dehiscence and subsequent closure induces reversible impaired decision-making
  4. 31624
    “…OUTCOMES: During the periconceptional period (defined here as the critical time window starting 1 month before conception), estrogens play a crucial role in endometrial receptivity, through the activation of paracrine/autocrine signaling. …”
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    The pathophysiological role of estrogens in the initial stages of pregnancy: molecular mechanisms and clinical implications for pregnancy outcome from the periconceptional period to end of the first trimester
  5. 31625
    “…Pneumonia was the most frequent misattribution failing to meet imaging, laboratory, or documentation requirements within the infection window period (IWP). Intra-abdominal infection was the second most frequent cause of misattribution due to not meeting the imaging or matching site culture within the IWP. …”
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    2419. Increasing Misattribution of Bacteremia as CLABSIs by NHSN Definitions: A Tertiary Care Center Perspective
  6. 31626
    “…Digital contraceptives have emerged as nonhormonal medical devices that make use of self-tracked data and algorithms to find a user’s fertile window. However, there is little knowledge about how people experience this seemingly new form of contraception, whose failure may result in unwanted pregnancies, high health risks, and life-changing consequences. …”
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    Analyzing User Reviews of the First Digital Contraceptive: Mixed Methods Study
  7. 31627
    “…These assessments include (1) use of a pedometer with a concealed viewing window for a two-week period to measure walking (2) a study centre visit during which venous blood is sampled for A1C, anthropometrics are assessed, and questionnaires are completed for measurement of other factors that may influence walking and/or A1C (e.g. food frequency, depressive symptomology, medications). …”
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    Walking behaviour and glycemic control in type 2 diabetes: seasonal and gender differences-Study design and methods
  8. 31628
    “…We observed a significant association (p < 0.05) of SNPs located in a haplotype block that encompasses a 65 kb region including the 3′ end of C5 as well as TRAF1. A sliding window analysis revealed an association peak at an intergenic region located ∼10 kb from both C5 and TRAF1. …”
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    A Candidate Gene Approach Identifies the TRAF1/C5 Region as a Risk Factor for Rheumatoid Arthritis
  9. 31629
    por Cohn, Alfred E.
    Publicado 1925
    “…First may be considered the effect of the unavoidable injury incident to cutting a window in the shell and removing so much of the shell membrane as to make the object visible. …”
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    PHYSIOLOGICAL ONTOGENY : A. CHICKEN EMBRYOS. V. ON THE RATE OF THE HEART BEAT DURING THE DEVELOPMENT OF CHICKEN EMBRYOS.
  10. 31630
    “…Furthermore data supports future studies focused on determining whether there is a high concentration window for resveratrol that is effective and non-toxic in high fat obesity murine models.…”
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    A high throughput live transparent animal bioassay to identify non-toxic small molecules or genes that regulate vertebrate fat metabolism for obesity drug development
  11. 31631
    “…BACKGROUND: Main claims of the literature are that functional recovery of the paretic upper limb is mainly defined within the first month post stroke and that rehabilitation services should preferably be applied intensively and in a task-oriented way within this particular time window. EXplaining PLastICITy after stroke (acronym EXPLICIT-stroke) aims to explore the underlying mechanisms of post stroke upper limb recovery. …”
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    Impact of early applied upper limb stimulation: The EXPLICIT-stroke programme design
  12. 31632
    “…Moreover, it identifies a safety and efficacy window for cefepime doses of 2 g every 12 hours in patients with a CL(Cr )≥ 50 ml/minute infected by pathogens with cefepime MICs ≤ 4 mg/l. …”
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    Prospective monitoring of cefepime in intensive care unit adult patients
  13. 31633
    “…Neutralization of the products reduced both anti-HIV-1 activity and cytotoxicity, resulting in a low therapeutic window for both acidic and neutralized formulations. …”
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    Safety and anti-HIV assessments of natural vaginal cleansing products in an established topical microbicides in vitro testing algorithm
  14. 31634
    “…Our sRNAscanner tool uses position weight matrices derived from experimentally defined E. coli K-12 MG1655 sRNA promoter and rho-independent terminator signals to identify intergenic sRNA TUs through sliding window based genome scans. Analysis of genomes representative of twelve species suggested that sRNAscanner demonstrated equivalent sensitivity to sRNAPredict2, the best performing bioinformatics tool available presently. …”
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    sRNAscanner: A Computational Tool for Intergenic Small RNA Detection in Bacterial Genomes
  15. 31635
    “…Besides accurately predicting HIV infection, sequential appearance of specific bands of WB test offers a window of opportunity to develop a less subjective tool for monitoring disease progression. …”
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    Human Immunodeficiency Virus (HIV) types Western blot (WB) band profiles as potential surrogate markers of HIV disease progression and predictors of vertical transmission in a cohort of infected but antiretroviral therapy naïve pregnant women in Harare, Zimbabwe
  16. 31636
    “…CO protected I/R-injured RGC with a therapeutic window at least up to 3 h (n = 8; RGC/mm(2); mean±S.D.: 1255±327 I/R only vs. 1956±157 immediate CO treatment, vs. 1830±109 1.5 h time lag and vs. 1626±122 3 h time lag; p<0.001). …”
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    Postconditioning with Inhaled Carbon Monoxide Counteracts Apoptosis and Neuroinflammation in the Ischemic Rat Retina
  17. 31637
    por Lewis, Patrick A.
    Publicado 2012
    “…In light of these data, it is likely that the enzymatic properties of LRRK2 afford us an important window into the biology of this protein, although whether they are potential drug targets for Parkinson's is open to debate. …”
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    Assaying the Kinase Activity of LRRK2 in vitro
  18. 31638
    “…The small molecule microRNA (miRNA) has opened a new window for prognostic markers, therapeutic targets and/or therapeutic components. …”
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    Validation of Expression Patterns for Nine miRNAs in 204 Lymph-Node Negative Breast Cancers
  19. 31639
    “…This study assessed mosquito catch rates of CDC light trap (CDC-LT), Ifakara tent trap (ITT), window exit trap (WET), pot resting trap (PRT), and box resting trap (BRT) relative to HLC in western Kenya to 1) identify appropriate methods for operational sampling in this region, and 2) contribute to a larger, overarching project comparing standardized evaluations of vector trapping methods across multiple countries. …”
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    Standardizing operational vector sampling techniques for measuring malaria transmission intensity: evaluation of six mosquito collection methods in western Kenya
  20. 31640
    “…The aim of this study was to investigate the relationship between the clinical Oxfordshire Community Stroke Project (OCSP) classification and MRI results taken within a 4.5-hour time window from stroke onset, with the hypothesis that the persistence of major arterial occlusion and extended ischemic penumbra, key criteria for proceeding with IA reperfusion therapy, would be distinctive between the clinical stroke subtypes. …”
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    Early Anticipation of Candidacy for Intra-Arterial Reperfusion Therapy Based on Baseline Clinical Stroke Subtypes: Comparison with Multiparametric MRI Taken within 4.5 Hours from Stroke Onset
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