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  1. 1721
    “…However, postsynaptic density-95 (PSD-95) and neuronal nitric oxide synthase (nNOS) coupling, the downstream signaling of NMDARs activation, obstructs the BDNF signaling transduction. Thus, we wondered distinct roles of NMDAR activation and PSD-95-nNOS coupling on fear extinction. …”
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    PSD-95-nNOS Coupling Regulates Contextual Fear Extinction in the Dorsal CA3
  2. 1722
    “…Because the acetyltransferase p300 was found to acetylate STAT3 on lysine 685 residues, we wondered whether p300 acetylates STAT3 in CLL cells. …”
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    STAT3 is constitutively acetylated on lysine 685 residues in chronic lymphocytic leukemia cells
  3. 1723
    “…Several studies introduced curcumin (diferuloylmethane) as a wonderful chemical in Curcuma longa (turmeric) with appropriate anti-inflammatory and antioxidant effects. …”
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    Curcumin effects on myeloperoxidase, interleukin-18 and matrix metalloproteinase-9 inflammatory biomarkers in patients with unstable angina: A randomized clinical trial
  4. 1724
    “…Surprisingly, cancer cells (MDA-MB-231) express, instead, alternative intracellular VEGFR-1 variants. We wondered if these variants, that are no longer dependent on ligands for activation, were expressed in a physiological context, specifically in spermatogenic cells, and whether their expression was maintained in spermatozoa and required for human fertility. …”
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    Two novel ligand-independent variants of the VEGFR-1 receptor are expressed in human testis and spermatozoa, one of them with the ability to activate SRC proto-oncogene tyrosine kinases
  5. 1725
    “…Current treatments still have many disadvantages and thereby the novel treatment aiming to relieve dysmenorrhea still needs to be further investigated. Mifepristone is a wonderful drug because it is effective, safe and cheap in many diseases including adenomyosis. …”
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    The new application of mifepristone in the relief of adenomyosis-caused dysmenorrhea
  6. 1726
    “…One of the common recommendations by clinicians is a trial of a lactose-free diet. We have wondered if there was sufficient evidence in the currently available literature to support such a recommendation. …”
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    Is There a Correlation Between Irritable Bowel Syndrome and Lactose Intolerance?
  7. 1727
    “…In a warming climate, the locations of suitable habitats are expected to change, as is the connectivity. Here, we wondered how climate change might affect shifts in habitat suitability and connectivity of habitat patches, as connectivity is a key element enabling species to realize a potential range shift. …”
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    Habitat patches for newts in the face of climate change: local scale assessment combining niche modelling and graph theory
  8. 1728
    “…Here, we report the generation of two induced pluripotent stem cell (iPSC)-lines from patients with radiographic hOA. Furthermore, we wondered whether these iPSC-lines carried single nucleotide polymorphisms (SNPs) within genes that have been associated with hOA. …”
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    Generation and characterization of human induced pluripotent stem cells (iPSCs) from hand osteoarthritis patient-derived fibroblasts
  9. 1729
    “…We further investigated the discriminate capability of the “11-gene-pair” for HCC recognition on several independent datasets. The wonderful results were obtained, demonstrating that the selected gene pairs can be signature for HCC. …”
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    Early Diagnosis of Hepatocellular Carcinoma Using Machine Learning Method
  10. 1730
    “…All varieties presented the same main phenols; anthocyanins and ellagitannins were widely variable among varieties, with the richest anthocyanin content in the juices from the Wonderful and Soft Seed Maule varieties (approx. 660 mg/L) and the highest ellagitannin content in the peel of the Black variety (approx. 133 mg/g dry matter). …”
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    Characterization of Arils Juice and Peel Decoction of Fifteen Varieties of Punica granatum L.: A Focus on Anthocyanins, Ellagitannins and Polysaccharides
  11. 1731
    por Witry, Matthew, Clayden, Alyssa
    Publicado 2020
    “…Respondents were asked for demographics and if Someone ever told you something concerning where you wondered if they were thinking about suicide for both work and one's personal life. …”
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    Student pharmacist personal and work experiences with people displaying warning signs of suicidal ideation
  12. 1732
    por Lindhout, Paul, Reniers, Genserik
    Publicado 2020
    “…However, social disruption and economic damage are becoming visible some 7 months after the Wuhan City outbreak early December 2019. The authors wondered what could have been done better in prevention and repression of the Covid-19 pandemic from a safety management and risk control point of view. …”
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    Reflecting on the safety zoo: Developing an integrated pandemics barrier model using early lessons from the Covid-19 pandemic
  13. 1733
    “…Immunocompromised individuals such as patients with HIV or decreased levels of CD4(+) T cells are highly susceptible to S. aureus infections, and they are also at increased risk of developing fungal infections. We therefore wondered whether stimulation of antifungal immunity might promote the type of immune responses needed for effective host defense against S. aureus. …”
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    Harnessing antifungal immunity in pursuit of a Staphylococcus aureus vaccine strategy
  14. 1734
    “…We are surrounded by wonders, something we could never have imagined erstwhile. …”
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    Traditional Nutritional and Health Practices Targeting Lifestyle Behavioral Changes in Humans
  15. 1735
    por Zoeller, Aaron C., Drewing, Knut
    Publicado 2020
    “…In contrast, performance with other fingers has rarely been investigated. We wondered which fingers are used in spontaneous exploration and if performance differences between fingers can explain spontaneous usage. …”
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    A Systematic Comparison of Perceptual Performance in Softness Discrimination with Different Fingers
  16. 1736
    por Couture, Roxanne, Martin, Luc J.
    Publicado 2020
    “…Since SOX and SF-1 transcription factors have been shown to cooperate to regulate gene expression in Sertoli cells, we wondered if such mechanism could be involved in the activation of Cx43 expression. …”
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    The transcription factors SF-1 and SOX8 cooperate to upregulate Cx43 expression in mouse TM4 sertoli cells
  17. 1737
    “…As northern Europeans often have blond hair and light eyes, we wondered whether iris colour may be a predisposing factor for UM and if so, why. …”
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    Iris Colour and the Risk of Developing Uveal Melanoma
  18. 1738
    “…In the present study, three commercial yeasts (for wine, beer, and cider) were evaluated for the production of pomegranate alcoholic beverage (PAB) from a juice of Wonderful variety. The physicochemical characteristics, antioxidant activity, and aromatic profiles of PABs were investigated before and after fermentation, while the effect of yeast strain and fermentation temperature (15 and 25 °C) was also evaluated. …”
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    Evaluation of Yeast Strains for Pomegranate Alcoholic Beverage Production: Effect on Physicochemical Characteristics, Antioxidant Activity, and Aroma Compounds
  19. 1739
    “…A series of studies suggested that certain Gram-negative bacteria were able to interact with dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin [DC-SIGN; cluster of differentiation (CD) 209] or langerin (CD207), thereby resulting in deposition of CD209s at infection sites. We wondered if Proteus mirabilis (a member of Proteobacteria family) could interact with APs through CD209/CD207. …”
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    Proteus mirabilis Targets Atherosclerosis Plaques in Human Coronary Arteries via DC-SIGN (CD209)
  20. 1740
    “…As the world held its breath for news surrounding COVID-19 and hunkered down amidst stay-at-home orders, medical students across the U.S. wondered if they would be called to serve on the front lines of the pandemic. …”
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    COVID 19: A Cause for Pause in Undergraduate Medical Education and Catalyst for Innovation
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