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  1. 1941
    “…Indeed, some patients may have an unfavorable anatomy and/or inadequate dosimetric constraints could be fulfilled ("complex cases"). In such cases, we wondered which treatment planning modality could be applied to achieve 3D-conformal APBI (2 mini-tangents and an "en face" electron field or non-coplanar photon multiple fields; or a mixed technique combining non-coplanar photon multiple fields with an "en face" electron beam). …”
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    Mixed modality treatment planning of accelerated partial breast irradiation: to improve complex dosimetry cases
  2. 1942
    “…These may range from deciding whether to pay serious attention to a particular problem that others claim is important, through to wondering how to convince others to agree that a problem is important. …”
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    SUPPORT Tools for evidence-informed health Policymaking (STP) 4: Using research evidence to clarify a problem
  3. 1943
    “…From the pool of 'one-hit-wonders', i.e. those ORFs specified by only one peptide detected by tandem mass spectrometry, we could confirm the probable existence of five additional new genes after proving that the corresponding RNAs were transcribed. …”
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    High-throughput proteogenomics of Ruegeria pomeroyi: seeding a better genomic annotation for the whole marine Roseobacter clade
  4. 1944
    “…Since astrocytes play a pivotal role in neuronal differentiation and synaptic regulation, we wondered if the beneficial in vivo effect could be mediated by astrocytes. …”
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    CNF1 Improves Astrocytic Ability to Support Neuronal Growth and Differentiation In vitro
  5. 1945
    “…To the winemaker, this yeast is integral to crafting wonderful, complex wines from simple, sugar-rich grape juice. …”
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    The winemaker’s bug: From ancient wisdom to opening new vistas with frontier yeast science
  6. 1946
    “…This model does not account for differences of transposition efficiency in human cells between mariners. We thus wondered whether apparent similarities in transposition cycle could hide differences in the intrinsic parameters that control mariner transposition. …”
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    Regulation of Mariner Transposition: The Peculiar Case of Mos1
  7. 1947
    “…We hypothesized that if this occurs in humans, then non-selective β-blockers should reduce the membrane diffusing capacity (D(M)), an index of lung interstitial fluid homeostasis. Moreover, we wondered whether this effect is potentiated by saline solution infusion, an intervention expected to cause interstitial lung edema. …”
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    Role of Alveolar β2-Adrenergic Receptors on Lung Fluid Clearance and Exercise Ventilation in Healthy Humans
  8. 1948
    “…BACKGROUND: With the Convulsive Status Guidelines due for renewal, we wondered if a phenytoin dose of ‘20 mg/kg’ would be easier to calculate correctly and therefore safer than the current ‘18 mg/kg’. …”
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    What is the easier and more reliable dose calculation for iv Phenytoin in children at risk of developing convulsive status epilepticus, 18 mg/kg or 20 mg/kg?
  9. 1949
    “…BACKGROUND: Staphylococcus epidermidis orthopedic device infections are caused by direct inoculation of commensal flora during surgery and remain rare, although S. epidermidis carriage is likely universal. We wondered whether S. epidermidis orthopedic device infection strains might constitute a sub-population of commensal isolates with specific virulence ability. …”
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    Staphylococcus epidermidis in Orthopedic Device Infections: The Role of Bacterial Internalization in Human Osteoblasts and Biofilm Formation
  10. 1950
    “…More than three-fourths of BPL participants (76.1%) believed that there were wondering homeless mentally ill in their community (χ(2) = 11.848, P < 0.01). …”
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    Human rights violations among economically disadvantaged women with mental illness: An Indian perspective
  11. 1951
    “…Our previous results with human Embryonic Stem Cells (hESC), suggested that PDHK could be a key regulator in the metabolic profile of pluripotent cells, as it is upregulated in pluripotent stem cells. Therefore, we wondered if metabolic modulation, via inexpensive pharmacological inhibition of PDHK, could impact metabolism and pluripotency. …”
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    Dichloroacetate, the Pyruvate Dehydrogenase Complex and the Modulation of mESC Pluripotency
  12. 1952
    “…Conclusion: This in-depth analysis which captures multiple perspectives results in robust recommendations for strategy revision informed by the Five Wonders of Change Framework. These recommendations point towards a more people-centred health system for improved equity and effectiveness and indicate priority areas for action if success of policy change through the roll-out of the revised strategy is to be realized.…”
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    Exploring perceptions of community health policy in Kenya and identifying implications for policy change
  13. 1953
    “…Mouse dental mesenchymal cells (mDMCs) isolated from the inductive dental mesenchyme of developing molars are frequently used in the context of tooth development and regeneration. We wondered if and how the odontogenic potential could be retained when mDMCs were cultured in vitro. …”
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    Remission for Loss of Odontogenic Potential in a New Micromilieu In Vitro
  14. 1954
    “…Here, we performed a systematic mini-review on brain MRS studies measuring GABA concentration in patients affected by schizophrenia (SZ), bipolar disorder (BD), and major depressive disorder (MDD). We wondered whether multimodal investigations could overcome intrinsic technical limits of MRS giving a broader view of mental disorders pathogenesis. …”
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    GABA System in Schizophrenia and Mood Disorders: A Mini Review on Third-Generation Imaging Studies
  15. 1955
    “…IMPORTANCE Subseafloor sediment provides a wonderful opportunity to investigate the drivers of microbial diversity in communities that may have been isolated for millions of years. …”
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    Relationship of Bacterial Richness to Organic Degradation Rate and Sediment Age in Subseafloor Sediment
  16. 1956
    “…As male moth behaviour depends also on its physiological state and previous experience with sensory signals, we wondered if insecticide effects would be dependent on plasticity of olfactory-guided behaviour. …”
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    An Insecticide Further Enhances Experience-Dependent Increased Behavioural Responses to Sex Pheromone in a Pest Insect
  17. 1957
    “…Taking into account that lupus patients exhibit an intestinal dysbiosis, we wondered whether altered FFA levels may be associated with the intestinal microbial composition in lupus patients. …”
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    Intestinal Dysbiosis Is Associated with Altered Short-Chain Fatty Acids and Serum-Free Fatty Acids in Systemic Lupus Erythematosus
  18. 1958
    “…We and others have used such assays extensively in the past, correlating decreases in cytotoxicity against specific targets with involvement of the blocked receptor(s). However, we wondered whether other mechanisms might be at play beyond cytotoxicity inhibition. …”
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    Apoptosis Induced via Gamma Delta T Cell Antigen Receptor “Blocking” Antibodies: A Cautionary Tale
  19. 1959
    “…BACKGROUND: Though Illumina has largely dominated the RNA-Seq field, the simultaneous availability of Ion Torrent has left scientists wondering which platform is most effective for differential gene expression (DGE) analysis. …”
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    A comparison of Illumina and Ion Torrent sequencing platforms in the context of differential gene expression
  20. 1960
    “…Considering the low permeability of the blood-brain barrier, we wondered if a reduced selective pressure by neutralizing antibodies (NAb) in the central nervous system (CNS) could favor the evolution of NAb-sensitive viruses in this compartment. …”
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    Probing the compartmentalization of HIV-1 in the central nervous system through its neutralization properties
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