“…Meanwhile, it has become increasingly evident that new assay technologies which provide robust and precise measurement of global histone modifications are required, for at least two pressing reasons: firstly, many approved drugs are known to influence histone modifications and new cancer therapies are increasingly being developed towards targeting histone deacetylases (HDACs) and other epigenetic readers and writers. Therefore, robust assays for fingerprinting the global effects of such drugs on preclinical cell, organoid and in vivo models is required; and secondly, robust histone-fingerprinting assays applicable to patient samples may afford the development of next-generation diagnostic and prognostic tools. …”
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“…METHODS: We integrated three m(6)A writers that catalyze the methylation of adenine on mRNA molecules. …”
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“…Additional knowledge translation efforts are needed to assist protocol writers address SPIRIT-PRO guidance and avoid research waste that may eventuate from sub-optimal PRO protocol content. …”
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“…Manuscripts will be written based on international authorship guidelines. No professional writers will be commissioned for manuscript drafting. …”
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“…In 1999 a visionary short article by The Wall Street Journal writers Robert Langreth and Michael Waldholz popularized the new term “personalized medicine,” that is to say, the targeting of drugs to each unique genetic profile. …”
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“…Recently, it was found that m6A writers or erasers affect the tumourigenesis of melanoma. …”
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“…Brown writes with a historical flair rare in science writers. - Brenda Maddox, Sunday Times;To read this book is almost to relive the European intellectual life of the last century. …”
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“…The population consisted of 8000 English writers' posts, from which 2000 posts with the highest interaction value were extracted. …”
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“…Taking into consideration all the accumulated data the writers tentatively present the hypothesis that the inhibitory factor is some metabolic product of the paratyphoid bacillus, possibly an enzyme, which is destroyed at a temperature somewhat above the thermal death point of the bacilli and which more gradually disappears from incubated cultures. …”
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“…Background: N6-methyladenosine (m(6)A) RNA methylation is dynamically and reversibly regulated by methyl-transferases ("writers"), binding proteins ("readers"), and demethylases ("erasers"). …”
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“…METHOD: A multidisciplinary team comprising of mental health clinicians, researchers, young adult fiction writers, a comic artist and young people with a lived experience of social anxiety developed the Entourage platform in collaboration. …”
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“…Information on procedures, participants, interventions, outcome measures, and results were independently extracted by three review writers (TS, SL, and RO). Trial authors were contacted for papers that were confusing or lacking information. …”
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“…A través de este ejercicio de análisis, no sólo se busca contribuir a la comprensión de los feminismos durante el porfiriato, sino hacer patentes las complejidades discursivas con que en la revista en cuestión, entre otras fuentes, se expresó una gama realmente amplia y plural de visiones sobre el papel que las mujeres de entonces debían desempeñar en la sociedad mexicana.Palabras clave: Discurso, Feminismo, Historiografía, Prensa femenina Discourses of science, nature, religion, history and power in the feminisms of La Mujer Mexicana (1904-1907)SummaryThe purpose of this work is to present the different ways in which the writers of the feminist magazine La Mujer Mexicana (The Mexican Woman) (1904-1907) understood the relationship between femininity, nature and the search for knowledge. …”
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“…There were correlations among the m6A readers, erasers, and writers. Five feature m6A regulatory genes, ZC3H13, YTHDF1, HNRNPA2B1, IGFBP2, and IGFBP3, were determined (p < 0.05) to establish a nomogram model that can predict the incidence of atrial fibrillation with the RF model. …”
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“…We used four well-established readability metrics that consider word frequencies and syntactic complexity to measure writers’ written communication ability. We then measured the lexical diversity by calculating the percentage of unique words in posts. …”
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“…In all, 11 apps had affiliations to universities and health services as app developers, writers, or editors. Furthermore, 33 apps were commercially developed. …”
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“…Myoclonus, blepharospasm, symptoms of the basal ganglia dysfunction, and organic writers' cramp were reported among participants. CONCLUSION: Patients treated with paroxetine, imipramine, fluoxetine, or clomipramine had a higher risk of developing di-EPS than patients treated with citalopram. …”
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“…The differential analysis identified 10 m6A-related genes: 5 writers [Methyltransferase-like 3 (METTL3), Methyltransferase-like 14 (METTL14), Wilms tumor 1-associated protein (WTAP), Zinc Finger CCCH-Type Containing 13 (ZC3H13), and Casitas B-lineage proto-oncogene like 1 (CBLL1)], 4 readers [YT521-B homology domain-containing family 3 (YTHDF3), Fragile X mental retardation type 1 (FMR1), YT521-B homology-domain-containing protein 1 (YTHDC1), and insulin-like growth factor binding protein 3 (IGFBP3)] and 1 eraser [fat mass and obesity associated (FTO) gene]. …”
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“…The expression of 21 m6A genes including m6A writers, erasers, readers, and immune cell infiltrates was analyzed in AD and healthy samples by differential analysis and ssGSEA method, respectively. …”
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“…Over the past year, we conducted creative writing workshops with kidney transplant recipients (KTRs), living kidney donors (LKDs), kidney transplant candidates (KTCs), and professional writers. During these workshops, patients were invited to explore different aspects of their experiences of their transplant or donation journey through narrative-writing, poetry, comic art, and screenwriting. …”
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