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261
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262por Swanson, Grace M., Estill, Molly, Diamond, Michael P., Legro, Richard S., Coutifaris, Christos, Barnhart, Kurt T., Huang, Hao, Hansen, Karl R., Trussell, J. C., Coward, R. Matthew, Zhang, Heping, Goodrich, Robert, Krawetz, Stephen A.“…Coregulatory networks linked by Chromatin remodeler cofactors, RNA interactors, Erasers and Writers (CREWs) were uncovered to reveal a hierarchical epigenetic response pathway.…”
Publicado 2019
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263
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264“…The aim of this study was two-fold: (1) To compare the performance of inaccurate writers who were not diagnosed with an LD with that of students who were diagnosed with an LD, in order to identify which tasks were the most challenging for individuals with LDs, and (2) to investigate whether inaccurate writers with and without a diagnosis differ in terms of self-perceived difficulties. …”
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265“…In this study, we report splice variant specific effects of a Ca(v)3.2 mutation found in patients with autosomal dominant writer’s cramp, a specific type of focal dystonia. …”
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266por Hirt, Lisa, Grassia, Fabio, Feuerstein, Jeanne, Thompson, John A., Ojemann, Steven, Kern, Drew S.“…BACKGROUND: Globus pallidus internus (GPi) deep brain stimulation (DBS) and thalamotomy are interventions for writer’s cramp (WC). Ventralis intermedius nucleus (VIM) DBS is targeted for tremor, however, many aspects of VIM DBS remained underexplored in WC. …”
Publicado 2021
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267“…We have identified 61 m(6)A pathway genes in Poplar 84K (Populus alba × Populus glandulosa), including 14 m(6)A writers, 14 m(6)A erasers and 33 m(6)A readers. Phylogenetic analysis indicated that the m(6)A writers and erasers were clustered into four groups and m(6)A readers were clustered into two groups. …”
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269RM2Target: a comprehensive database for targets of writers, erasers and readers of RNA modificationspor Bao, Xiaoqiong, Zhang, Yin, Li, Huiqin, Teng, Yuyan, Ma, Lixia, Chen, Zhihang, Luo, Xiaotong, Zheng, Jian, Zhao, An, Ren, Jian, Zuo, Zhixiang“…RNA modification is a dynamic and reversible process regulated by a series of writers, erasers and readers (WERs). Abnormal changes of WERs will disrupt the RNA modification homeostasis of their target genes, leading to the dysregulation of RNA metabolisms such as RNA stability and translation, and consequently to diseases such as cancer. …”
Publicado 2022
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270por Zhang, Lupeng, Qu, Chiwen, Shi, Chen, Wu, Fan, Tang, Yifan, Li, Yue, Li, Jinlong, Feng, Huicong, Zhong, Suye, Yang, Jun, Zeng, Xiaomin, Peng, Xiaoning“…However, the potential role of RNA modification “writer” genes in the immune microenvironment of gliomas and their effect on the response to immunotherapy remains unclear. …”
Publicado 2023
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271por Ge, Yiling, Zhang, Yihan, Yang, Sheng, Liu, Tong, Zhang, Tianyi, Feng, Yanlu, Wang, Chuntao, Liang, GeyuEnlace del recurso
Publicado 2023
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273por Hashimoto, Yasunari, Ota, Tetsuo, Mukaino, Masahiko, Liu, Meigen, Ushiba, Junichi“…We recorded electroencephalograms (EEGs) over the bilateral sensorimotor cortex from a patient suffering from chronic writer’s cramp. The patient was asked to suppress an exaggerated beta frequency component in the EEG during hand extension. …”
Publicado 2014
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274
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275por Mendel, Mateusz, Chen, Kuan-Ming, Homolka, David, Gos, Pascal, Pandey, Radha Raman, McCarthy, Andrew A., Pillai, Ramesh S.“…While the METTL3/METTL14 heterodimer adds this mark on thousands of transcripts in a single-stranded context, the substrate requirements and physiological roles of the second m(6)A writer METTL16 remain unknown. Here we describe the crystal structure of human METTL16 to reveal a methyltransferase domain furnished with an extra N-terminal module, which together form a deep-cut groove that is essential for RNA binding. …”
Publicado 2018
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276por Panneerdoss, Subbarayalu, Eedunuri, Vijay K., Yadav, Pooja, Timilsina, Santosh, Rajamanickam, Subapriya, Viswanadhapalli, Suryavathi, Abdelfattah, Nourhan, Onyeagucha, Benjamin C., Cui, Xiadong, Lai, Zhao, Mohammad, Tabrez A., Gupta, Yogesh K., Huang, Tim Hui-Ming, Huang, Yufei, Chen, Yidong, Rao, Manjeet K.“…We discover that hypoxia alters the level/activity of writers, erasers, and readers, leading to decreased m(6)A and consequently increased expression of target transcripts in cancer cells. …”
Publicado 2018
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277por Song, Yiyou, Xu, Qingru, Wei, Zhen, Zhen, Di, Su, Jionglong, Chen, Kunqi, Meng, Jia“…Our method achieved reasonable performance on both the writer target prediction (as high as 0.918) and the eraser target prediction (as high as 0.888) in a 5-fold cross-validation, and results of the gene ontology analysis of their preferential targets further revealed the functional relevance of different RNA methylation writers and erasers.…”
Publicado 2019
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278por Naro, Antonino, Billeri, Luana, Portaro, Simona, Bramanti, Placido, Calabrò, Rocco Salvatore“…The treatment of writer’s cramp (W’sC) is essentially based on the use of botulinum toxin. …”
Publicado 2019
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279
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280por Leonardi, Andrea, Kovalchuk, Nataliia, Yin, Lei, Endres, Lauren, Evke, Sara, Nevins, Steven, Martin, Samuel, Dedon, Peter C., Melendez, J. Andres, Van Winkle, Laura, Zhang, Qing-Yu, Ding, Xinxin, Begley, Thomas J.“…The epitranscriptomic writer Alkylation Repair Homolog 8 (ALKBH8) is a transfer RNA (tRNA) methyltransferase that modifies the wobble uridine of selenocysteine tRNA to promote the specialized translation of selenoproteins. …”
Publicado 2020
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