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581por Huang, Kerson“…Written by a highly respected writer and researcher, it first develops traditional concepts, including Feynman graphs, before moving on to key topics such as functional integrals, statistical mechanics, and Wilson's renormalization group. …”
Publicado 1998
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582“…Through this unique dataset of writing clouds, we expose a representation of the writing process that quantifies its complexity and the writer’s efforts throughout the draft and through time. …”
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583“…However, at the end of the year, both DLA and CR students’ transactional writer beliefs were predictive of writing self-efficacy. …”
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584“…We propose a two-step model of swiveling of target A upon conversion to m(6)A and sensing its methylation status by the cryptic pocket, enabling it to actuate enzymes’ switch from writer to an m(6)A-sensor. Cancer-associated mutations cannot distinguish methylated from unmethylated adenine and show impaired RNA binding, de-stacking, and defective m(6)A writing and sensing.…”
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585“…These modifications are added and removed by enzymes (writers) and can be recognized by nucleosome-binding proteins (readers). …”
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586por Bradnam, Lynley V., Graetz, Lynton J., McDonnell, Michelle N., Ridding, Michael C.“…Dystonia severity was assessed using the Writer’s Cramp Rating Scale (WRCS) and the Arm Dystonia Disability Scale (ADDS). …”
Publicado 2015
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587“…By sequencing transcriptome-wide RNA methylation at single-base-resolution, we identified human METTL4 as the writer that directly methylates Am at U2 snRNA position 30 into m(6)Am. …”
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588por Kumar, Sunil, Nagpal, Ravinder, Kumar, Amit, Ashraf, Muhammad Umer, Bae, Yong-Soo“…Here, we have described how RNA m6A-modification machineries EEE (Editor/writer: Mettl3, Mettl14; Eraser/remover: FTO, ALKBH5, and Effector/reader: YTHDF-1/2) could be reformed into potential druggable candidates or as RNA-modifying drugs (RMD) to treat leukaemia. …”
Publicado 2021
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589por van den Homberg, Daphne A. L., van der Kwast, Reginald V. C. T., Quax, Paul H. A., Nossent, A. Yaël“…The modification is reversible and can be dynamically regulated by writer and eraser enzymes. Alteration in the levels of these enzymes can lead to changes in mRNA stability, alternative splicing or microRNA processing, depending on the m6A-binding proteins. …”
Publicado 2022
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590Dynamic assembly of the mRNA m(6)A methyltransferase complex is regulated by METTL3 phase separationpor Han, Dasol, Longhini, Andrew P., Zhang, Xuemei, Hoang, Vivian, Wilson, Maxwell Z., Kosik, Kenneth S.“…The recruitment of the mRNA m(6)A methyltransferase writer complex to phase-separated nuclear speckles is likely to be crucial in its regulation; however, control over the activity of the complex remains unclear. …”
Publicado 2022
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591por Zhang, Mi, Bodi, Zsuzsanna, Mackinnon, Katarzyna, Zhong, Silin, Archer, Nathan, Mongan, Nigel P., Simpson, Gordon G., Fray, Rupert G.“…The methyltransferase complex (m(6)A writer), which catalyzes the deposition of N(6)-methyladenosine (m(6)A) in mRNAs, is highly conserved across most eukaryotic organisms, but its components and interactions between them are still far from fully understood. …”
Publicado 2022
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592por Wang, Duo, Yan, Fuxiang, Wu, Ping, Ge, Kexue, Li, Muchun, Li, Tingting, Gao, Ying, Peng, Chao, Chen, Yong“…Here, we systematically characterize writer, eraser, and reader proteins of histone Kbz in S. cerevisiae using proteomic, biochemical, and structural approaches. …”
Publicado 2022
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593por Yang, Haibo, Wang, Yumin, Xiang, Yufei, Yadav, Tribhuwan, Ouyang, Jian, Phoon, Laiyee, Zhu, Xueping, Shi, Yi, Zou, Lee, Lan, Li“…Here, we identified that Fragile X mental retardation protein (FMRP) promotes transcription-coupled HR via its interaction with both the m5C writer TRDMT1 and the m5C eraser ten-eleven translocation protein 1 (TET1). …”
Publicado 2022
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594“…The influence of modifications of m6A on the stability of RNA depends upon the expression of methyltransferase (“writer”) and demethylase (“eraser”) and m6A binding protein (“reader”). …”
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598por Nahin, Paul J“…This is what Digital Dice is all about: how to get numerical answers to difficult probability problems without having to solve complicated mathematical equations. Popular-math writer Paul Nahin challenges readers to solve twenty-one difficult but fun problems, from determining the odds of coin-flip…”
Publicado 2008
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599por Gribbin, John“…From award-winning science writer John Gribbin, "Science: A History" is the enthralling story of the men and women who changed the way we see the world, and the turbulent times they lived in. …”
Publicado 2002
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600“…Deeply engaged with the events of his tumultuous times, from the two world wars and the Holocaust, to the atomic bomb and the Cold War, to the effort to establish a Jewish homeland, Einstein was a remarkably prolific political writer, someone who took courageous and often unpopular stands against nationalism, militarism, anti-Semitism, racism, and McCarthyism. …”
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