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821“…Methyltransferase-like 14 (METTL14) is a particularly important m6A methylation 'writer' that can recognize RNA substrates. METTL14 has been documented to improve the activity and catalytic efficiency of METTL3. …”
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822por Chambers, Robert“…The experiments with the NH(4)Cl are similar to, and corroborate micro injection experiments performed in connection with some work on mustard gas in which the writer collaborated. Eggs immersed in sea water containing decomposed mustard gas, at a certain low concentration are not affected. …”
Publicado 1922
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823por Nowling, Ronald J., Vyas, Jay, Weatherby, Gerard, Fenwick, Matthew W., Ellis, Heidi J. C., Gryk, Michael R.“…This first is translation of NMR spectral data (time and frequency domain) to a single in-memory data model to allow addition of new file formats with two converter modules, a reader and a writer, instead of writing a separate converter to each existing format. …”
Publicado 2011
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824“…Because being a fluent reader–writer entails thousands of hours of experience with eye and hand movement in the direction dictated by one’s writing system, it could be that writing system direction affects the axis used to represent time in terms of space. …”
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825por Barbara, Piccoli Giorgina“…His achievements as a writer were at least comparable: Hamburger was awarded several important literary prizes, including prix Femina, prix Balzac and the Cino del Duca prize (1979), awarded, among others, to Jorge Luis Borges and Konrad Lorenz. …”
Publicado 2013
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826por Theler, Dominik, Dominguez, Cyril, Blatter, Markus, Boudet, Julien, Allain, Frédéric H.-T.“…Impairment of methylase or demethylase functions are associated with severe phenotypes and diseases in several organisms. Beside writer and eraser enzymes of this dynamic RNA epigenetic modification, reader proteins that recognize this modification are involved in numerous cellular processes. …”
Publicado 2014
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827por Tiedemann, Rochelle L., Hlady, Ryan A., Hanavan, Paul D., Lake, Douglas F., Tibes, Raoul, Lee, Jeong-Heon, Choi, Jeong-Hyeon, Ho, Thai H., Robertson, Keith D.“…Clear cell renal cell carcinomas (ccRCCs) harbor frequent mutations in epigenetic modifiers including SETD2, the H3K36me3 writer. We profiled DNA methylation (5mC) across the genome in cell line-based models of SETD2 inactivation and SETD2 mutant primary tumors because 5mC has been linked to H3K36me3 and is therapeutically targetable. …”
Publicado 2015
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828“…The high sensitivity is enabled in part by the pole's strong magnetic gradient of up to 28 × 10(6) T m(−1) and in part by the absence of non-contact friction due to the extremely flat writer surface. In addition, we demonstrate quantitative imaging of the pole field with ∼10 nm spatial resolution. …”
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829“…Recent neurobiological data suggest a solution to the questions regarding the writer’s retrospective diagnosis, claiming the insular cortex to be the origin of the rare ecstatic seizures. …”
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830“…In parallel he had a rich artistic and cultural activity as writer and playwright: he was president of the Transylvanian Writers’ Society, editor of a literary review, director of the Cluj theater and opera, leader of a book club and founder of a symphony orchestra.…”
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831por Růžička, Kamil, Zhang, Mi, Campilho, Ana, Bodi, Zsuzsanna, Kashif, Muhammad, Saleh, Mária, Eeckhout, Dominique, El‐Showk, Sedeer, Li, Hongying, Zhong, Silin, De Jaeger, Geert, Mongan, Nigel P., Hejátko, Jan, Helariutta, Ykä, Fray, Rupert G.“…Using combined methods of genetics, proteomics and RNA biochemistry, we identified a core set of mRNA m(6)A writer proteins in Arabidopsis thaliana. The components required for m(6)A in Arabidopsis included MTA, MTB, FIP37, VIRILIZER and the E3 ubiquitin ligase HAKAI. …”
Publicado 2017
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832por Michieletto, Davide, Chiang, Michael, Colì, Davide, Papantonis, Argyris, Orlandini, Enzo, Cook, Peter R, Marenduzzo, Davide“…The coupling between readers and writers drives spreading of biochemical marks and sustains the memory of local chromatin states across replication and mitosis. …”
Publicado 2018
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833“…The m(6)A modification is regulated by three classes of proteins generally referred to as the “writer” (adenosine methyltransferase), “eraser” (m(6)A demethylating enzyme), and “reader” (m(6)A-binding protein). …”
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834“…It has been reported that food bioactives regulate histone acetylation via direct regulation of writer (histone acetyl transferases, HATs) and eraser (histone deacetylases, HDACs) proteins. …”
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835“…We explore four mechanisms for how a review writer’s social class may affect readers’ evaluations of the organization. …”
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836“…A tightly balanced regulation exists between the “writers” and “readers” in order to mediate normal cellular functions. …”
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837“…SMITER (Synthetic mzML writer) is a Python-based command-line tool designed to simulate liquid-chromatography-coupled tandem mass spectrometry LC-MS/MS runs. …”
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838por Ghosh, Asish K.“…Acetyltransferase p300, a major epigenetic writer of acetylation on histones and transcription factors, contributes significantly to modifications of chromatin landscape of genes involved in cellular aging and cardiovascular diseases. …”
Publicado 2021
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839por Qin, Yanqin, Li, Binghua, Arumugam, Suyavaran, Lu, Qiuxia, Mankash, Salah M., Li, Junzi, Sun, Beicheng, Li, Jiansheng, Flavell, Richard A., Li, Hua-Bing, Ouyang, Xinshou“…Here, we show that myeloid lineage-restricted deletion of the m(6)A “writer” protein Methyltransferase Like 3 (METTL3) prevents age-related and diet-induced development of NAFLD and obesity in mice with improved inflammatory and metabolic phenotypes. …”
Publicado 2021
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840por Rengaraj, Praveenkumar, Obrdlík, Aleš, Vukić, Dragana, Varadarajan, Nandan Mysore, Keegan, Liam P., Vaňáčová, Štěpánka, O’Connell, Mary A.“…Each type of modification is deposited by a specific writer, many types of modification are recognized and interpreted by several different readers and some types of modifications can be removed by eraser enzymes. …”
Publicado 2021
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