“…N(6)-methyl-adenosine (m(6)A) is the most prevalent mRNA modification, established by “writer” and “eraser” proteins. It influences the clockwork in several taxa, but only few studies have been conducted in plants and none in marine plants. …”
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“…The dynamics of DNA base methylation depends mainly on the activities of the writer/eraser guided by non-coding RNA (ncRNA) and regulated by the developmental/environmental cues. …”
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“…To accommodate these differences, we describe a basidiomycete model for nonself recognition using post-translational modification, based on a reader-writer system as found in other organisms. This post-translational modification combined with nuclear migration allows for the coexistence of two genomes in one individual while maintaining nonself recognition during all life stages. …”
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“…Therefore, in this paper, we elucidated the biological functions and molecular mechanisms of m6A modification in the carcinogenesis of HCC by illustrating three different regulatory factors ("writer", "eraser", and "reader") of the m6A modification process. …”
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“…We have developed the first nanoscale DNA storage writer, which we expect to scale DNA write density to 25 × 10(6) sequences per square centimeter, three orders of magnitude improvement over existing DNA synthesis arrays. …”
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“…Since the first discovery of the corresponding demethylase and the subsequent identification of m(6)A as a dynamic modification, the function and mechanism of m(6)A in mammalian gene regulation have been extensively investigated. “Writer”, “eraser” and “reader” proteins are key proteins involved in the dynamic regulation of m(6)A modifications, through the anchoring, removal, and interpretation of m(6)A modifications, respectively. …”
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“…The deposition and function of these modifications are mediated by the actions of writer, reader, and eraser proteins. At the cellular level, RNA modifications regulate several cellular processes including cell death, proliferation, senescence, differentiation, migration, metabolism, autophagy, the DNA damage response, and liquid-liquid phase separation. …”
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“…Adam E Snook was the most prolific writer, while Dung T. Le was the most commonly co-cited author. …”
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“…Lay audiences gave more positive ratings to films and novels by writers who used a more gender-congruent writing style, in contrast with professional critics, who gave more positive reviews to films by writers who used a more gender-incongruent writing style. …”
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“…Unlike RNAPII-dependent H3K4me2 associated with transcription, RNAPII-independent H3K4me2 requires Nup100, SET3C, the Leo1 subunit of the Paf1 complex and, upon degradation of an essential transcription factor, is inherited through multiple cell cycles. The writer of this mark (COMPASS) physically interacts with the potential reader (SET3C), suggesting a molecular mechanism for the spreading and re-incorporation of H3K4me2 following DNA replication.…”
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“…The role and mechanisms of m6A in mammalian gene regulation have been extensively studied. The “Writer”, “eraser”, and “reader” proteins are key proteins involved in the dynamic regulation of m6A modifications. …”
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“…This process is regulated by countless enzymes called “writer, reader, and eraser,” and the performance is precisely controlled. …”
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“…Recent studies showed that m(6)A “writer” genes (Mettl3 and Mettl14) play an essential role in HSC. …”
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“…Hebert was the most productive writer, and Antonia Trichopoulou was the most co-cited author. …”
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“…The m(6)A mark, similar to many other RNA modifications, is strictly regulated by so-called ‘writer’, ‘reader’, and ‘eraser’ protein species. The abundance of genes coding for the expression of these regulator proteins and m(6)A levels shows great potential as diagnostic and predictive tools across several cancer fields. …”
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“…Addressing the fear and mistrust that is rapidly spreading, Federoff and her co-author, science writer Nancy Brown, weave a narrative rich in history, technology, and science to dispel myths and misunderstandings. …”
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“…In this book, he draws on his many experiences as an optical and atomic physicist--and on his consummate skills as a teacher and writer about the mysteries of physics--to present a remarkable tour of the world of light. …”
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“…Jeff Hecht, authoritative science writer on the historical development of the laser, author of books on lasers and fiber optics.…”
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“…This article presents an analytical reading of the extraordinarily rich cultural production around drugs by the 20th-century French poet, writer, critic, and visual artist Michaux (1899–1984). …”
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“…Here, we showed that paracrine factors from infected cells alter expression of another epigenetic writer, EZH2, coordinate with proliferation. Urothelial cells were inoculated with UPEC, UPEC derivatives, or vehicle (mock infection) at low moi, washed, then maintained in media with Gentamycin. …”
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