“…Here we characterize the function of N-acetyltransferase 10 (Nat10), a writer for N4-acetylcytidine (ac4C) on RNA molecules, in mouse oocyte development. …”
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“…METHODS: We developed a deep learning algorithm, DystoniaBoTXNet, which uses a 3D convolutional neural network architecture and raw structural brain magnetic resonance images (MRIs) to automatically discover and test a neural network biomarker of BoTX efficacy in 284 patients with 4 different forms of focal dystonia, including laryngeal dystonia, blepharospasm, cervical dystonia, and writer’s cramp. RESULTS: DystoniaBoTXNet identified clusters in superior parietal lobule, inferior and middle frontal gyri, middle orbital gyrus, inferior temporal gyrus, corpus callosum, inferior fronto-occipital fasciculus, and anterior thalamic radiation as components of the treatment biomarker. …”
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“…In addition, a number of supplementary features are proposed based on empirical study and observations and are combined with CNN-extracted features to augment the child and adult writer-group classification. Lastly, the performance of the extracted deep and supplementary features is evaluated and compared using different classifiers, comprising Softmax, support vector machine (SVM), k-nearest neighbor (KNN), and random forest (RF), as well as different dataset combinations from Hijja for child data and AHCD for adult data. …”
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“…Further validation assays demonstrate that genetic inactivation of NAT10, the ac(4)C writer enzyme, led to ac(4)C level decrease on target genes, promoted the core pluripotency regulator OCT4 (POU5F1) transcript decay, and finally impaired self-renewal and promoted early differentiation in hESCs. …”
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“…The binding of YT521-B promotor or m(6)A writer Ime4/ Mettl14 to BuGZ controls its coacervation, indicating that the promotor may accelerate the phase transition of its binding transcription factor. …”
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“…The involvement of the writer, reader, and eraser in m6A modification impacts the advancement of tumors through the regulation of RNA stability, nuclear export, translation efficiency, and RNA degradation. …”
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“…The competitive endogenous RNA (ceRNA) network was predicted to supply the possible role of circRNAs in RPL occurrence, and we further analyzed the profiles of nine m6A regulators (seven readers, one writer and one eraser) managed by circRNAs in this network. …”
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“…Collectively, our study revealed the unappreciated dual role of METTL3 as an m(6)A writer and a transcription regulator, which worked together in the same signaling pathway to drive colorectal cancer malignancy.…”
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“…The reason for the discrepancy between the values derived, by the method adopted by the writer, and the values given in the literature is explained by Fig. 1.…”
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“…Tyrosine kinase (TK) circuits, each of which consists of a TK writer, a kinase substrate, and a related reader, such as Src homology (SH) 2 domains and pTyr-binding (PTB) domains, comprise the core machinery of the pTyr signaling network. …”
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“…For the HM readers, writers and erasers, we provided further ChIP-Seq analysis data for the targeted HMs and schematized the relationships between them. …”
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“…A closed form expression for the probability density function (pdf) of the SNR at the destination reader/writer and outage probability are derived. Analytical results are verified through simulations. …”
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“…We showed previously that P53 pro-apoptotic target promoters are enriched with H3K9me3 mark and induction of P53 abrogates this repressive chromatin conformation by down-regulating SUV39H1, the writer of this mark present on these promoters. In the present study, we demonstrate that in response to P53 stabilization, its pro-apoptotic target promoters become enriched with the H3K4me3 epigenetic mark as well as its readers, Wdr5, RbBP5 and Ash2L, which were not observed in response to SUV39H1 down-regulation alone. …”
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“…OBJECTIVES: Based on the clinical observation that children with AE often exhibit, interictally, a disorder resembling writer’s cramp but fully definable as dysgraphia, we tested the hypothesis that in this particular population dysgraphia would represent a subtle expression of dystonia. …”
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“…The essay shows that X-phemisms (orthophemisms and/or euphemisms and/or dysphemisms) are motivated by a speaker/writer’s want to be seen to take a certain stance by upgrading, downgrading, obfuscating, and deceiving; and they extensively manifest indulgence in verbal play. …”
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“…INTRODUCTION: Like nonverbal cues in oral interactions, text‐based emoticons, which are textual portrayals of a writer's facial expressions, are commonly used in electronic device–mediated communication. …”
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“…PARTICIPANTS: An Endocrine Society-appointed Task Force of experts, a methodologist, and a medical writer developed the guideline. EVIDENCE: This evidence-based guideline was developed using the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) system to describe both the strength of recommendations and the quality of evidence. …”
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“…With the progression of embryogenesis, methylation of H3K9 increased, correlating with gene expression profiles of BnHKMT SUVR4-like and BnLSD1-like (writer and eraser enzymes of H3K9me2). At early stages, BIX-01294 promoted cell reprogramming, totipotency and embryogenesis induction, while diminishing bulk H3K9 methylation. …”
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“…We further knocked out the only “writer” of H3K79 methylation in yeast, and observed that expression noise is indeed increased. …”
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“…However, in these studies, changes in the object's location were always consistent with world knowledge (e.g., in “The writer picked up the pen from the floor and moved it to the desk,” the floor and the desk are both common locations for a pen). …”
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