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961“…We use Word Accumulation Curves, Hierarchical Clustering overlays, Principal Component Analysis, and Linear Discriminant Analysis techniques in combination with RPAS, a multi-faceted text analysis approach that draws on a writer's personality, or self to identify subtle characteristics within a person's writing style. …”
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962“…Thus, female identity is secured by an H3K9me3 epigenetic pathway in which Sxl is the upstream female-specific regulator, SETDB1 is the required chromatin writer, and phf7 is one of the critical SETDB1 target genes.…”
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963“…The mRNA m6A modification has been characterized biochemically, molecularly, and phenotypically, including elucidation of its methyltransferase complexes (m6A writer), demethylases (m6A eraser), and direct interaction proteins (readers), while limited information on the DNA m6dA is available. …”
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964por Rosi, M., Levi, S. T., Pistolesi, M., Bertagnini, A., Brunelli, D., Cannavò, V., Di Renzoni, A., Ferranti, F., Renzulli, A., Yoon, D.“…The destructive power of this event is also possibly related to a huge marine storm that devastated the ports of Naples in 1343 (200 km north of Stromboli) described by the famous writer Petrarch. The portrayed devastation can be potentially attributed to the arrival of multiple tsunami waves generated by a major landslide in Stromboli island, confirming the hypothetical hazard of these phenomena at a regional scale.…”
Publicado 2019
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965por Hu, Po, Zhao, Hongwei, Zhu, Pei, Xiao, Yongsheng, Miao, Weili, Wang, Yinsheng, Jin, Hailing“…These results reveal that both the arginine methylation writer (PRMT5) and readers (TSNs) can regulate AGO2-mediated RNAi.…”
Publicado 2019
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966“…Key to resolving distinct chromatin signatures of diabetic complications is the identification of the true physiological targets of regulatory proteins, such as reader proteins that recognise, writer proteins that deposit and eraser proteins that remove specific chemical moieties. …”
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967por Sajini, Abdulrahim A., Choudhury, Nila Roy, Wagner, Rebecca E., Bornelöv, Susanne, Selmi, Tommaso, Spanos, Christos, Dietmann, Sabine, Rappsilber, Juri, Michlewski, Gracjan, Frye, Michaela“…The presence and absence of RNA modifications regulates RNA metabolism by modulating the binding of writer, reader, and eraser proteins. For 5-methylcytosine (m(5)C) however, it is largely unknown how it recruits or repels RNA-binding proteins. …”
Publicado 2019
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968“…We also demonstrate that the HSP90 inhibitor-mediated increase in expression of DNAJB4 protein occurs partly through an epitranscriptomic mechanism, and is substantially modulated by the writer, eraser, and reader proteins of N(6)-methyladenosine (m(6)A). …”
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969por Jabs, Sabrina, Biton, Anne, Bécavin, Christophe, Nahori, Marie-Anne, Ghozlane, Amine, Pagliuso, Alessandro, Spanò, Giulia, Guérineau, Vincent, Touboul, David, Giai Gianetto, Quentin, Chaze, Thibault, Matondo, Mariette, Dillies, Marie-Agnès, Cossart, Pascale“…We analyze expression levels of several known writer and eraser enzymes, and find that the methyltransferase Mettl16 is downregulated in absence of a microbiota, and one of its target mRNAs, encoding S-adenosylmethionine synthase Mat2a, is less methylated. …”
Publicado 2020
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970por de Mendoza, Alex, Poppe, Daniel, Buckberry, Sam, Pflueger, Jahnvi, Albertin, Caroline B., Daish, Tasman, Bertrand, Stephanie, de la Calle-Mustienes, Elisa, Gomez-Skarmeta, Jose Luis, Nery, Joseph R., Ecker, Joseph R., Baer, Boris, Ragsdale, Clifton W., Grützner, Frank, Escriva, Hector, Venkatesh, Byrappa, Bogdanovic, Ozren, Lister, Ryan“…Concomitantly, we found that the writer of non-CpG methylation, DNMT3A, and the reader, MeCP2, originated at the onset of vertebrates as a result of the ancestral vertebrate whole genome duplication. …”
Publicado 2021
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971“…Therefore, they rely not only on the quality of arguments or novelty of findings to persuade readers but also linguistic markers in the form of metadiscourse to assert a position on an issue, increase readability of a text, engage readers, and avoid objection to the writer’s interpretations, thereby enhancing the credibility of the text. …”
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972por Mugat, Bruno, Nicot, Simon, Varela-Chavez, Carolina, Jourdan, Christophe, Sato, Kaoru, Basyuk, Eugenia, Juge, François, Siomi, Mikiko C., Pélisson, Alain, Chambeyron, Séverine“…Therefore, drosophila piRNA-mediated transcriptional silencing involves three epigenetic effectors, a remodeler, Mi-2, an eraser, Rpd3 and a writer, SetDB1, in addition to the Su(var)2-10 SUMO ligase.…”
Publicado 2020
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973por Verhoeven, Deb, Musial, Katarzyna, Palmer, Stuart, Taylor, Sarah, Abidi, Shaukat, Zemaityte, Vejune, Simpson, Lachlan“…Studies of gender inequality in film industries have noted the persistence of male domination in creative roles (usually defined as director, producer, writer) and the slow pace of reform. Typical policy remedies are premised on aggregate counts of women as a proportion of overall industry participation. …”
Publicado 2020
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974por Thau, Tena“…But what if we could free our desires from this fixation on looks? Science fiction writer Ted Chiang has explored this possibility in a fascinating short story – and scientific developments might, in the future, move it beyond the realm of fiction. …”
Publicado 2020
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975“…Establishment of these epigenetic marks is important in defining cellular identity and for maintaining normal cell function, as evidenced by rare genetic disorders of epigenetic writers involved in H3K27 post-translational modification. …”
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976por Shaus, Arie, Gerber, Yana, Faigenbaum-Golovin, Shira, Sober, Barak, Piasetzky, Eli, Finkelstein, Israel“…Remarkably, the forensic examination reveals a high probability of at least 12 writers within the analyzed corpus. This is a major increment over the previously published algorithmic estimations, which revealed 4–7 writers for the same assemblage. …”
Publicado 2020
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977por Lu, Thomas X., Zheng, Zhong, Zhang, Linda, Sun, Hui-Lung, Bissonnette, Marc, Huang, Haochu, He, Chuan“…We aim to study how deletion of a critical component of m(6)A writer complex, METTL14, in T cells affects the development of colitis. …”
Publicado 2020
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978por Cotter, Eric J., Rasmussen, Luke H., Johnson, Kristina P., Hennessy, David W., Cannada, Lisa K., Whiting, Paul S.“…CONCLUSIONS: According to hip and knee arthroplasty fellowship PDs, the interview, letters of recommendation, and personal connections to the applicant and/or letter writers are the most important factors considered in selecting arthroplasty fellowship candidates.…”
Publicado 2020
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979por Shi, Hongjie, Zhao, Jinping, Han, Linzhi, Xu, Ming, Wang, Kaijie, Shi, Jiajun, Dong, Zhe“…Patients with any CNVs of regulators genes had worse overall survival (OS) than those with diploid genes. The deletion of m6A writer genes was an independent risk factor for poor OS, and the effect synergized with that of copy number gain of eraser genes. …”
Publicado 2020
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980“…Analyses of the semi-structured interviews establish seven conception categories that are specifically related to the use of ISV-VR for descriptive Chinese composition writing: (1) offering students more observational opportunities; (2) improving students’ writing skills; (3) promoting students’ learning participation and motivation; (4) shifting learning from teacher-centric to student-centric, (5) enhancing collaborative learning among students; (6) cultivating students’ positive values and moral character, and (7) shaping students’ self-identity as “writers.” The concurrent and convenient access to the ISV-VR resources was for the teachers an enriched and supportive environment for them to cultivate students’ writer identity. …”
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