“…FCA immunoprecipitates with components of the m(6)A writer complex, and m(6)A modification affects dynamics of FCA nuclear condensates, and promotes FLC chromatin silencing. …”
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“…Of those, 50.5% and 47.3%, respectively, failed to mention the real and complete names of the writer and editor. Reports improperly mentioned specific details about the time, place, methods, and perpetrators of violence in 42.1%, 36.4%, 45.4%, and 54.6% of cases, respectively. …”
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“…My reflections draw attention to the General German Women's Association (German: Allgemeiner Deutscher Frauenverein—ADF), which was founded on 18th October 1865 under the chairwomanship of writer, journalist and publicist Louise Otto-Peters (1819–1865). …”
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“…With this profile BT can be used to treat cranial dystonia, cervical dystonia and limb dystonia including writer’s and musician's cramps. The recent introduction of BT high dose therapy also allows to treat more wide-spread dystonia including segmental and generalised dystonia. …”
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“…Additionally, upregulation of the writer gene ALKBH5 had a positive correlation with the activation of AKT pathways in the TCGA database. …”
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“…The mechanisms by which m(6)A is deposited, processed, and potentially removed are increasingly understood. Writer enzymes include METTL3 and METTL14 while YTHDC1 and YTHDF1 are key reader proteins, which recognize and bind the m(6)A mark. …”
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“…DNA methylation occurs through the action of DNA methyl transferase enzymes: writer DNA methyl transferases add methyl groups to specific regions of unmethylated DNA; maintenance DNA methyl transferases reproduce the pattern of DNA methylation during genome replication. …”
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“…N(6)-methyladenosine (m(6)A) modification is dynamically regulated by “writer” and “eraser” enzymes. m(6)A “writers” have been shown to ensure the homeostasis of CD4(+) T cells, but the “erasers” functioning in T cells is poorly understood. …”
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“…RESULTS: There was a 25% recurrence rate of tremors for PD after thalamotomy. Writer’s cramp rating scale improved from a mean of 10.54–1.6 in task specific dystonia (TSD) patients, after thalamotomy. …”
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“…As one of the most studied ribonucleic acid (RNA) modifications in eukaryotes, N(6)‐methyladenosine (m(6)A) has been shown to play a predominant role in controlling gene expression and influence physiological and pathological processes such as oncogenesis and tumor progression. Writer and eraser proteins, acting opposite to deposit and remove m(6)A epigenetic marks, respectively, shape the cellular m(6)A landscape, while reader proteins preferentially recognize m(6)A modifications and mediate fate decision of the methylated RNAs, including RNA synthesis, splicing, exportation, translation, and stability. …”
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“…The multiple roles played by this modification explains why m(6)A misregulation is connected to multiple human cancers. The m(6)A/m(6)Am writer enzymes are RNA methyltransferases (MTases). …”
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“…The m(6)A modification is primarily associated with three types of protease, which are encoded by the writer, eraser and reader genes, respectively. It has been shown that the m(6)A methylation has close connections with the occurrence and development of many tumors, including glioma. …”
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“…We evaluated the scores of the Writer's Cramp Rating Scale (WCRS, 0–30; higher scores indicating greater severity), Tubiana Musician's Dystonia Scale (TMDS, 0–5; lower scores indicating greater severity), and Arm Dystonia Disability Scale (ADDS, 0%–100%; lower scores indicating greater disability) at baseline and 3 and 12 months post‐treatment. …”
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“…This finding was consistent with downregulated expression of METTL3 and WTAP, two members of the m(6)A writer complex, in LPS-exposed aortas. Microarray analysis of m(6)A methylation indicated that 40 transcripts (31 mRNAs and 9 lncRNAs) were hypermethylated, while 223 transcripts (156 mRNAs and 67 lncRNAs) were hypomethylated, in aortic tissue from LPS-treated rats. …”
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“…Here, we evaluated the impact of m(6)A writers, erasers and readers on HRSV genomic RNA accumulation and inclusion bodies assembly during viral replication. …”
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“…However, recent investigations have demonstrated a key involvement of this chromatin writer in maintaining the self-renewal and tumor-initiating capacities of cancer stem cells (CSCs). …”
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“…Previous studies indicated that m(6)A methyltransferase METTL3 (‘writer’) and demethylase FTO (‘eraser’) play critical roles in heart‐related disease. …”
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“…Here, we tested the effect of N(6)-methyladenosine (m(6)A) modification on miRNA export into EVs by depletion of METTL3 and ALKBH5, a writer and eraser of m(6)A modification, respectively. …”
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“…They provided opportunity to learn about self, were considered a gift to both writer and recipient and fostered intergenerational interaction and transcendence. …”
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“…Since no pain relief was achieved, spinal cord stimulation was performed using spectra WaveWriter system, placing 2 octopolar linear leads over the bilateral T8 and T9 vertebras with the help of a 3-dimensional neural targeting program. …”
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