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1001por Sabharwal, Ankit, Kar, Bibekananda, Restrepo-Castillo, Santiago, Holmberg, Shannon R., Mathew, Neal D., Kendall, Benjamin Luke, Cotter, Ryan P., WareJoncas, Zachary, Seiler, Christoph, Nakamaru-Ogiso, Eiko, Clark, Karl J., Ekker, Stephen C.“…We report here the FusX TALE Base Editor (FusXTBE) to facilitate broad-based access to TALE mitochondrial base editing technology. TALE Writer is a de novo in silico design tool to map potential mtDNA base editing sites. …”
Publicado 2021
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1002“…Adjectival collexemes are frequently deployed for all four stance types: Epistemic stance, Evaluation stance, Dynamic stance, and Deontic stance, while verbal collexemes are valuable lexical resources for the Epistemic stance, as their use entails modalized evidentiality, pointing to epistemic judgment of the writer-speaker toward events/propositions. Close examination of the use of adjectival and verbal collexemes identified three fundamental meanings of the INTRODUCTORY IT PATTERN. …”
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1003“…Carroll, is the director of Education and Workforce Development for the Indiana CTSI and a popular writer covering health, research, and policy for The New York Times. …”
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1004por Zhang, Mengxue, Urabe, Go, Ozer, Hatice Gulcin, Xie, Xiujie, Webb, Amy, Shirasu, Takuro, Li, Jing, Han, Renzhi, Kent, K Craig, Wang, Bowen, Guo, Lian-Wang“…H3K27ac and its reader BRD4 (bromodomain protein) co-enriched at Ezh2; conditional BRD4 knockout in injured mouse arteries reduced H3K27me3 and its writer EZH2, which positively regulated another pro-IH chromatin modulator UHRF1. …”
Publicado 2022
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1005por Islam, Ammad Ul, Khan, Muhammad Jaleed, Asad, Muhammad, Khan, Haris Ahmad, Khurshid, Khurram“…The previous methods use synthetic mixed samples created by joining different parts of the images from the UWA WIHSI dataset.Each document consists of real mixed samples written withdifferent pens and by different writers with a variety of mixing ratios of inks and writers for forensic analysis.The standard A4 pages, each weighing 70 gs and manufactured by “AA” company, are used for data collection. …”
Publicado 2022
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1006“…All three of us—the researcher, the writer, and the animator—have been marked and “re‐shaped” by our work related to creating Lily; we have learned more about children like Lily and their mothers, and we have learned more about ourselves and our humanity. …”
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1007por Song, Jinyi, Zhang, Lele, Li, Chenhui, Maimaiti, Munire, Sun, Jing, Hu, Jiameng, Li, Lu, Zhang, Xiang, Wang, Chen, Hu, Haiyang“…Loss of IFNAR1 led to the dysregulation of cs-lncRNAs resembled that of loss of an essential subunit of m(6)A writer METTL14. We also found m(6)A system affected transcriptional machinery to modulate cs-lncRNAs by targeting multiple crucial transcription factors. …”
Publicado 2022
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1008por Jiang, Ling, Liu, Xueqi, Hu, Xueru, Gao, Li, Zeng, Hanxu, Wang, Xian, Huang, Yuebo, Zhu, Wei, Wang, Jianan, Wen, Jiagen, Meng, Xiaoming, Wu, Yonggui“…Targeting m6A through the writer enzyme METTL3 is a potential approach for the treatment of DN.…”
Publicado 2022
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1009por Shen, Hui, Luo, Baobing, Wang, Yunshu, Li, Jing, Hu, Zongli, Xie, Qiaoli, Wu, Ting, Chen, Guoping“…Notably, the orthologs of newly identified single-strand DNA (ssDNA) 6mA writer–eraser–reader also existed in the tomato genome. …”
Publicado 2022
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1010“…A total of 2706 related literature were retrieved. The most prolific writer was found to be Kathryn H Schmitz (21 articles). …”
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1011por Lyu, Yuanyuan, Zhang, Yilin, Wang, Yuhan, Luo, Yonghong, Ding, Huafeng, Li, Peiling, Ni, Guantai“…WT1-associated protein (WTAP) has an important “writer” role in m6A modification, and it is also a nuclear protein that colocalizes with splicing factors and plays a critical role in cell function and cancer progression. …”
Publicado 2022
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1012“…Post-translational modifications of histones are epigenetic processes that are fine-tuned by writer and eraser enzymes, and the disorganization of these enzymes alters the cellular state, resulting in human diseases. …”
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1013“…In particular, we demonstrated the key role of the reader-writer module of PRC2 and of the competition between the binding of activating and repressing enzymes in shaping the H3K27 landscape around transcriptional start sites. …”
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1014por Edwardes, Lucy V., Caswell, Sarah J., Giurrandino, Mariacarmela, Zhai, Xiang, Gohlke, Andrea, Kostomiris, Demetrios H., Pollard, Hannah K., Pflug, Alexander, Hamm, Gregory R., Jervis, Kate V., Clarkson, Paul N., Syson, Karl“…[Image: see text] Human lysine methyltransferase 2D (hKMT2D) is an epigenetic writer catalyzing the methylation of histone 3 lysine 4. hKMT2D by itself has little catalytic activity and reaches full activation as part of the WRAD2 complex, additionally comprising binding partners WDR5, RbBP5, Ash2L, and DPY30. …”
Publicado 2022
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1015por Hodassman, Shiri, Meir, Yuval, Kisos, Karin, Ben-Noam, Itamar, Tugendhaft, Yael, Goldental, Amir, Vardi, Roni, Kanter, Ido“…ID-nets are also implemented for writer-dependent recognition, and suggested as a cryptographic tool for encrypted authentication. …”
Publicado 2022
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1016por Lyu, Peng-fei, Wang, Yu, Meng, Qing-Xiang, Fan, Ping-ming, Ma, Ke, Xiao, Sha, Cao, Xun-chen, Lin, Guang-Xun, Dong, Si-yuan“…Li J is the most prolific writer in AAIC. Through clustering analysis and high-frequency keyword research, it has been shown that AI plays a significantly important role in the prediction, diagnosis, treatment and prognosis of cancer. …”
Publicado 2022
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1017“…The model distinguishes six roles (hats): consumer adviser, teacher, judge, writer, stakeholder, and artist advocate. It identifies core principles governing critical writing for music as well as challenges that arise from balancing the above six responsibilities whilst remaining true to an implicit code of conduct. …”
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1018por Niedzialkowska, Ewa, Liu, Limin, Kuscu, Cem, Mayo, Zachary, Minor, Wladek, Strahl, Brian D., Adli, Mazhar, Stukenberg, P. Todd“…Here we describe how Tip60 acetylates histone H3 at lysine 4 (H3K4ac) to block both the H3T3ph writer and the reader to ensure that this mitotic signaling cannot begin before prophase. …”
Publicado 2022
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1019“…In addition to these results, there is only one high positive correlation among the six reading subskills; that is between the subskill to identify ideas and opinions of the writer and the subskill to scan a text to find specific information (0.749). …”
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1020“…To fill this research gap, the present study implements AWE software, WRITER, for peer and self-editing. For this purpose, a pre-post quasi-experimental research design with convenience sampling is done for automated and non-automated editing of cause-effect essay writing. …”
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