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  1. 1061
    “…Then, we elucidated whether transcription factor‐activating enhancer‐binding protein 2C (TFAP2C) was functionally m(6)A‐modified by methyltransferase‐like protein 3 (METTL3), which acted as an m(6)A ‘writer’, and insulin‐like growth factor 2 mRNA‐binding protein 1 (IGF2BP1), which acted as an m(6)A ‘reader’. …”
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    METTL3 potentiates resistance to cisplatin through m(6)A modification of TFAP2C in seminoma
  2. 1062
    “…Although both early and late viral transcripts contain m(6)A, depletion of m(6)A writer METTL3 specifically impacts viral late transcripts by reducing their splicing efficiency. …”
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    Direct RNA sequencing reveals m(6)A modifications on adenovirus RNA are necessary for efficient splicing
  3. 1063
    “…CONCLUSION: An automated report that connects the attending to antimicrobial orders by attaching it to the note writer was found to be comparable to manual chart review as well as an average of use for the PICU compared to the national database PHIS. …”
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    163. Automation of an Inpatient Provider Specific Antimicrobial Use Report
  4. 1064
    “…We discover that m(6)A ‘writer’ METTL3 facilitates L1 retrotransposition, whereas m(6)A ‘eraser’ ALKBH5 suppresses it. …”
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    L1 retrotransposons exploit RNA m(6)A modification as an evolutionary driving force
  5. 1065
    “…RNA m(6)A methylation is controlled by a multiprotein “writer” complex including the enzymatic factor methyltransferase-like protein 3 (METTL3) that regulates methylation and two “eraser” proteins, RNA demethylase ALKBH5 (ALKBH5) and fat mass- and obesity-associated protein (FTO), that demethylate m(6)A in transcripts. …”
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    m(6)A-RNA Demethylase FTO Inhibitors Impair Self-Renewal in Glioblastoma Stem Cells
  6. 1066
    por Zhu, Wei, Wang, Jing-Zi, Wei, Ji-Fu, Lu, Chen
    Publicado 2021
    “…The reversible regulation of m6A modification is affected by the so-called ‘reader’, ‘writer’ and ‘eraser’. As a required component and the largest methyltransferase, vir-like m6A methyltransferase associated (VIRMA) can promote the progression of cancer and is associated with poor survival in multiple types of cancer. …”
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    Role of m6A methyltransferase component VIRMA in multiple human cancers (Review)
  7. 1067
    “…We also found that spontaneous arm dystonia requires higher BT doses in a proximal application pattern, whereas task specific writer's cramp requires considerably reduced BT doses with a distal application pattern. …”
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    Botulinum toxin dosing in arm muscles: contextual factors
  8. 1068
    “…No correlation was found between the down-regulated RNA modifications and the expression level of corresponding writer genes. Whereas, the expression level of a specific exonuclease gene, RNase J1, was detected to be higher in cells grown on inulin.…”
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    Epitranscriptomic profile of Lactobacillus agilis and its adaptation to growth on inulin
  9. 1069
    “…Other key components of LORs include the specialty of the letter-writer, according to 84% of respondents, with anesthesiology as the most valuable specialty. …”
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    Attitudes towards and impact of letters of recommendation for anesthesiology residency applicants
  10. 1070
    por Yen, Ya-Ping, Chen, Jun-An
    Publicado 2021
    “…This modification is installed by m(6)A methylation “writers” (Mettl3/Mettl14 methyltransferase complex), and it can be reversed by demethylase “erasers” (Fto and Alkbh5). …”
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    The m(6)A epitranscriptome on neural development and degeneration
  11. 1071
    “…Kcr is conserved and is regulated by a series of enzymes and co-enzymes including lysine crotonyltransferase (writer), lysine decrotonylase (eraser), certain YEATS proteins (reader), and crotonyl-coenzyme A (donor). …”
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    Emerging roles of non-histone protein crotonylation in biomedicine
  12. 1072
    “…Our work adds functional and molecular insights into the mechanism of the m(6)A mRNA writer complex.…”
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    Hakai is required for stabilization of core components of the m(6)A mRNA methylation machinery
  13. 1073
    “…Our findings uncover that mRNA m(5)C is tightly controlled by an elaborate two-enzyme system, and the protein-RNA structure analysis strategy established may be applied to other RNA modification writers to distinguish the functions of different RNA substrates of a writer protein.…”
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    Sequence- and structure-selective mRNA m(5)C methylation by NSUN6 in animals
  14. 1074
    “…Here we report decreased expression of the m(6)A “writer” METTL3 in tumor-infiltrating NK cells, and a positive correlation between protein expression levels of METTL3 and effector molecules in NK cells. …”
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    METTL3-mediated m(6)A RNA methylation promotes the anti-tumour immunity of natural killer cells
  15. 1075
    por Bäckryd, Emmanuel
    Publicado 2021
    “…METHODS: The circumstances of prescribing sleeping pills in the early 20(th) century are illustrated by summarizing the main storyline of a novel by Swedish writer Vilhelm Moberg. This is followed by a thought experiment and a theoretical discussion. …”
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    The pharmaceuticalisation of life? A fictional case report of insomnia with a thought experiment
  16. 1076
    “…Here we identify 65 predicted readers, writers, and erasers of histone acetylation and methylation encoded in the T. brucei genome and, by epitope tagging, systemically localize 60 of them in the parasite's bloodstream form. …”
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    A systematic analysis of Trypanosoma brucei chromatin factors identifies novel protein interaction networks associated with sites of transcription initiation and termination
  17. 1077
    “…Outcomes of the discussion were then correlated with published evidence by an independent medical writer. The final consensus includes clinically implementable recommendations to provide guidance in treating Taiwanese mCRC patients. …”
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    Taiwan Society of Colon and Rectal Surgeons Consensus on mCRC Treatment
  18. 1078
    “…Mice lacking the m6A writer enzymes METTL3 in IECs (Mettl3ΔIEC) were resistant to RV infection and showed increased expression of interferons (IFNs) and IFN-stimulated genes (ISGs). …”
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    m6A modifications regulate intestinal immunity and rotavirus infection
  19. 1079
    por Vaasjo, Lee O.
    Publicado 2022
    “…Both pathways can guide the m(6)A writer complex, facilitate m(6)A methylation and modulate protein translation. …”
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    LncRNAs and Chromatin Modifications Pattern m(6)A Methylation at the Untranslated Regions of mRNAs
  20. 1080
    “…Mechanistically, LINC01273 complementarity bound to miR-600, served as a ‘reservoir’ increasing miR-600 stability, and facilitating miR-600 targeting methyltransferase 3 (METTL3), a m(6)A ‘writer’, resulting in reducing METTL3 level. In addition, LINC01273 was modified with m(6)A, METTL3 increased LINC01273 m(6)A modification, followed by LINC01273 decay in the presence of YTHDF2, a m(6)A ‘reader’. …”
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    Long intergenic non-protein coding RNA 1273 confers sorafenib resistance in hepatocellular carcinoma via regulation of methyltransferase 3
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