“…Lysine-specific methyltransferase 2A (KMT2A) is responsible for methylation of histone H3 (K4H3me) and contributes to chromatin remodeling, acting as “writer” of the epigenetic machinery. Mutations in KMT2A were first reported in Wiedemann–Steiner syndrome (WDSTS). …”
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“…This modification is reversible, and its related biological functions are mediated by “writers,” “erasers,” and “readers.” The field of viral epitranscriptomics and the role of m(6)A modification in virus–host interaction have attracted much attention recently. …”
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“…Given the crucial function of H3K36me3 in genome regulation, the roles of H3K36me3 and its sole methyltransferase SETD2 in pathogenesis, especially malignancies, have been emphasized in many studies, and it is conceivable that disruption of histone methylation regulatory network composed of “writer”, “eraser”, “reader”, and the mutation of H3K36me3 codes have the capacity of powerfully modulating cancer initiation and development. …”
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“…Together, the parts of our study provide a plausible mechanism for N6mA writer and reader proteins acting directly on lesion-containing DNA, and suggest in vivo experiments to test the mechanisms involving methylation of adenine.…”
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“…Disruptor of telomeric silencing 1‐like (DOT1L) is the only non‐SET domain histone lysine methyltransferase (KMT) and writer of H3K79 methylation on nucleosomes marked by H2B ubiquitination. …”
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“…This study was designed to investigate an m6A writer Mettl14 on cardiac ischemia–reperfusion (I/R) injury and uncover the underlying mechanism. …”
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“…This may indicate that the writer did not know how to use the current discharge template, and therefore support with using this is indicated. …”
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“…Clinically, the pilot department had a statistically significant increase in dictation and NoteWriter tool note composition from their baseline month to their observed month. …”
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“…BACKGROUND: N(6)-methyladenosine (m(6)A) is the methylation of RNA adenosines that participates in multiple biological processes, such as facilitating translation of host genes via the reader protein YTHDF1. The core writer protein of m(6)A in humans is METTL3. METHODS: We utilized YTHDF1 target genes and normal or si-METTL3 NGS (next-generation sequencing) data from HeLa cells generated by a previous work and collected known human oncogenes from a website. …”
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“…Results: Mutation pattern analysis revealed that 32% of 656 patients had genetic alterations. Four genes (writer: methyltransferase like 3 [METTL3] and three readers: insulin like growth factor 2 mRNA binding protein 2 [IGF2BP2], heterogeneous nuclear ribonucleoprotein C [HNRNPC], and heterogeneous nuclear ribonucleoprotein A2/B1 [HNRNPA2B1]) were selected to construct a survival risk prediction model and the results of immunohistochemical staining showed that the expression of these four m6A genes was significantly different between lung adenocarcinoma tissues and normal lung tissues (p < .01). …”
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“…The binding and interaction between the m6A “writer” methyltransferase-like 3 (METTL3) or the m6A “reader” YT521-B homology (YTH) domain-containing protein YTHDF1 and the suppressor of cytokine signaling 3 (SOCS3), as a major regulator of the inflammatory response, were explored in differentiated TP-infected THP-1 cells as well as in secondary syphilitic lesions from patients. …”
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“…Herein, we showed that the expression of the m(6)A modification “writer” Mettl14 was increased in coronary heart disease and LPS-stimulated THP-1 cells. …”
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“…In this review we discuss how histone methylation by Set2/SETD2 has led the way in connecting histone modifications in active regions of the genome to chromatin functions and how SETD2 is leading the way to showing that we also have to look beyond histones to truly understand the physiological role of an ‘epigenetic’ writer enzyme in normal cells and in disease.…”
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“…The temporal discrimination threshold (TDT) has been established as a biomarker of impaired temporal processing and endophenotype in various forms of focal dystonia patients, such as cervical dystonia, writer’s cramp or blepharospasm. The role of TDT in musician’s dystonia (MD) in contrast is less clear with preceding studies reporting inconclusive results. …”
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“…We first estimated the abnormal expression patterns of potential m(6)A regulators when all the driver genes are mutated, using The Cancer Genome Atlas and Gene Expression Omnibus databases. METTL16, an m(6)A“writer,” was chosen as a unique candidate of PDA, owing to its markedly differential expression under mutations of all driver genes (KRAS, TP53, CDKN2A, and SMAD4) and its favorable prognostic value. …”
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“…Then, we identified the correlation between “eraser” genes and “writer” genes. We tested the predictive abilities of the 11 m6A regulators based on another dataset and verified their expression in primary human endometrial stromal cells. …”
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“…We observed the situation that the knockdown of m(6)A “writer” protein methyltransferase-like (METTL)3 in the chondrogenesis of SMSCs. …”
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“…Specifically, we reveal an H3K9me1/2 reader, CEC-5, both by in vitro biochemistry and in vivo ChIP assays. MET-2, an H3K9me1/2 writer, is required for CEC-5 association with heterochromatin. …”
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“…With this book as your guide, you'll learn how to: Look beyond the labels, and better understand the diversity of ELs, English language proficiency levels, and sociopolitical influences Teach and assess through reader's workshop, recognizing where comprehensible input fits in and adapting recurring features like support, choice, conferencing, and academic conversations Teach and assess through writer's workshops, including modifications to quick-writes, minilessons, conferencing, sharing, and more Teach through structures and community with classroom schedules and behavior norms, and activities like All About Me Paragraphs and Six Things You Need to Know About Me Listicles Embrace identity in inquiry cycles via research and family interviews, mentor texts and essays, pictorial autobiographies, memory paragraphs, and more Answer your own FAQs such as How do I teach students if I don't know their language? …”
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“…My analysis focuses on a little-known text from 1902, Perfiles del terruño by Cayetano Rodríguez Beltrán, a writer from Tlacotalpan, Veracruz. Vis-à-vis key Foucauldian concepts such as “economic-juridical ensemble” and homo œconomicus, I read Rodríguez Beltrán’s costumbrista typology of social characters in the Veracruzan entrepôt of Tlacotalpan as an attempt to safeguard a region’s cultural and racial identity while simultaneously subsuming its population as economic and juridical subjects. …”
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