“…WTAP, a major RNA m(6)A writer, stabilized FX and FVII mRNA and enhanced their nuclear export in CD45(+)EPCs from the TME. …”
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“…KIAA1429 is one type of N6-methyladenosine (m6A) writer that plays a tumor-progressive role in various cancers, but the role of KIAA1429 in ES remains to be elucidated. …”
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“…The combined IHC panel, including “writer”, “reader”, and “target”, exhibited a better prognostic value for CRC patients than any of these components individually. …”
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“…PPI network showed proteins from multiple epigenetic regulator families were involved post- pazopanib resistance, including subunits of chromatin remodeler SWI/SNF complex ARID1A/1B and SMARCA4, histone acetylation writers CREBBP, histone methylation writer NSD1 and erasers KDM6A/5A. …”
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“…Previous reports in other adult stem cell systems have identified alterations in the most abundant internal mRNA modification, N6-methyladenosine (m(6)A), conferred by its active writer, METTL3, to regulate cell state transitions through alterations in the transcriptional profile of these cells. …”
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“…The low quality of elective letters leads to the recommendation that writers should decline to write them, programs should not require them and trainees should not request them. …”
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“…Although it is unclear whether patient underwent total thyroidectomy or subtotal thyroidectomy for initial intervention, the recurrence of thyrotoxicosis after such a long period of time has not previously been reported in the literature to the knowledge of this writer. This has important implications regarding the underlying pathophysiology of Graves’ disease and the ability of remnant thyroid tissue to regenerate over time. …”
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“…All VPS16 patients showed mild progressive dystonia with writer's cramp as the presenting symptom between age 7 and 34 years (mean 20 years) that often progressed to generalized dystonia and was even accompanied by hyperkinetic movements and myoclonus in 1 patient. …”
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“…We performed a database mining on 102 transcriptomic datasets for the expressions of 29 m(6)A-RNA methylation (epitranscriptomic) regulators (m(6)A-RMRs) in 41 diseases and cancers and made significant findings: (1) a few m(6)A-RMRs were upregulated; and most m(6)A-RMRs were downregulated in sepsis, acute respiratory distress syndrome, shock, and trauma; (2) half of 29 m(6)A-RMRs were downregulated in atherosclerosis; (3) inflammatory bowel disease and rheumatoid arthritis modulated m(6)A-RMRs more than lupus and psoriasis; (4) some organ failures shared eight upregulated m(6)A-RMRs; end-stage renal failure (ESRF) downregulated 85% of m(6)A-RMRs; (5) Middle-East respiratory syndrome coronavirus infections modulated m(6)A-RMRs the most among viral infections; (6) proinflammatory oxPAPC modulated m(6)A-RMRs more than DAMP stimulation including LPS and oxLDL; (7) upregulated m(6)A-RMRs were more than downregulated m(6)A-RMRs in cancer types; five types of cancers upregulated ≥10 m(6)A-RMRs; (8) proinflammatory M1 macrophages upregulated seven m(6)A-RMRs; (9) 86% of m(6)A-RMRs were differentially expressed in the six clusters of CD4(+)Foxp3(+) immunosuppressive Treg, and 8 out of 12 Treg signatures regulated m(6)A-RMRs; (10) immune checkpoint receptors TIM3, TIGIT, PD-L2, and CTLA4 modulated m(6)A-RMRs, and inhibition of CD40 upregulated m(6)A-RMRs; (11) cytokines and interferons modulated m(6)A-RMRs; (12) NF-κB and JAK/STAT pathways upregulated more than downregulated m(6)A-RMRs whereas TP53, PTEN, and APC did the opposite; (13) methionine-homocysteine-methyl cycle enzyme Mthfd1 downregulated more than upregulated m(6)A-RMRs; (14) m(6)A writer RBM15 and one m(6)A eraser FTO, H3K4 methyltransferase MLL1, and DNA methyltransferase, DNMT1, regulated m(6)A-RMRs; and (15) 40 out of 165 ROS regulators were modulated by m(6)A eraser FTO and two m(6)A writers METTL3 and WTAP. …”
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“…BACKGROUND: RNA adenosine modifications, which are primarily mediated by “writer” enzymes (RMWs), play a key role in epigenetic regulation in various biological processes, including tumorigenesis. …”
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“…METHODS: The correlation between RNA m(5)C methylation, m(5)C writer NOP2/Sun RNA methyltransferase family member 2 (NSUN2) and EGFR-TKIs resistance was determined in non-small-cell lung cancer (NSCLC) cell lines and patient samples. …”
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“…However, the role of m7G modifications within mRNA and its “writer” methyltransferase 1(METTL1) in tumors, particularly prostate cancer (PCa), has not been revealed. …”
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“…And METTL3 induced GBAP1 expression by acting as the m(6)A writer of GBAP1 and IGF2BP2 worked as its m(6)A reader. …”
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“…All six studies addressed the effect of smileys or emoticons on participant responses, message interpretation, or social presence of the writer. None of these studies specifically targeted chronic conditions. …”
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“…RESULTS: The global mRNA m6A methylation level significantly increased in LSCC patients. RBM15, as a “writer” of methyltransferase, was significantly increased in LSCC and was associated with unfavorable prognosis. …”
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“…Bioinformatic analysis and RT-qPCR were performed to evaluate the expression of IGF2BPs and m(6)A writer Wilms tumor 1-associating protein (WTAP) in RCC samples and its correlation with patient prognosis. …”
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“…Lindholm, MD, American Board of Internal Medicine (Individual(s) Involved: Self): Member of Auxiliary R&D Infectious Disease Item-Writer Task Force. No financial support received. …”
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“…It is known to be evolutionarily conserved machinery present in the last eukaryotic common ancestor (LECA). The writers and erasers responsible for adding or removing m(6)A belong to specific protein families, respectively, suggesting that these members are evolutionarily related. …”
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“…METTL3 was identified as the m6A writer, with YTHDF2 as the reader protein of LATS1 mRNA, which plays a positive role in promoting both tumorigenesis and glycolysis in breast cancer. …”
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