“…We show how this method differs from other measures of correlation, and exemplify how it can reveal shared covariance between histone modifications and DNA binding proteins, such as the relationship between the H3K4me3 chromatin mark and its epigenetic writers and readers. AVAILABILITY AND IMPLEMENTATION: An R/Bioconductor package is available at http://bioconductor.org/packages/fCCAC/. …”
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“…Drinking water demands cause fluorosis in the villages around the area residents and based on the findings of this study writers are announced suggestions below in order to take care of the health of area residents.…”
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“…Here, we review the principal histone modifications and their enzymatic writers and erasers that have been studied to date; we discuss what is currently known about their roles in heart failure and in the diabetic heart; we draw on lessons learned from the studies of microvascular and macrovascular complications; and we speculate that therapeutically manipulating histone modifications may alter the natural history of heart failure in diabetes.…”
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“…Lysine methylations mark various sites on the tail and globular domains of histones and their levels are precisely balanced by the action of methyltransferases (‘writers’) and demethylases (‘erasers’). In addition, distinct effector proteins (‘readers’) recognize specific methyl-lysines in a manner that depends on the neighboring amino-acid sequence and methylation state. …”
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“…It is reversible via regulation of m(6)A modification methyltransferase, demethylase and proteins that preferentially recognize m(6)A modification as “writers”, “erasers” and “readers”, respectively. Altered expression levels of the m(6)A modification key regulators substantially affect their function, leading to significant phenotype changes in the cell and organism. …”
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“…Moreover, the transcription cofactor, Vgll4l regulates epigenetic programming in LRO progenitors by controlling the expression of writers and readers of DNA methylation marks. Altogether, our study uncovers a novel and essential role for the transcriptional effectors and regulators of the Hippo pathway in establishing LR asymmetry.…”
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“…The epigenetic regulators include writers, such as DNA methyltransferases (DNMTs); histone acetyltransferases (HATs) and histone lysine methyltransferases; erasers, such as histone deacetylases (HDACs); histone lysine demethylases [e.g., the Lysine Demethylase (KDM) family]; DNA hydroxylases; readers, such as the methyl-CpG-binding proteins (MBPs); and bromodomain-containing proteins, including the bromo- and extraterminal domain (BET) family. …”
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“…The methyltransferases METTL3‐METTL14 and METTL16 act as “writers” for different target transcripts and sequence motifs. …”
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“…As with DNA modification-mediated control of gene expression, regulation of gene expression via RNA modification is also accomplished by three groups of proteins: writers, readers, and erasers. Several emerging studies have revealed that dysregulation in RNA modification is closely associated with tumorigenesis. …”
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“…In this review, we summarized the advances in the understanding of histone modifications in the regulation of chondrocyte fate, cartilage development and pathology, particularly the molecular writers, erasers and readers involved. In addition, we have highlighted recent studies on the use of small molecules and drugs to manipulate histone signals to regulate chondrocyte functions or treat cartilage lesions, in particular osteoarthritis (OA), and discussed their potential therapeutic benefits and limitations in preventing articular cartilage degeneration or promoting its repair or regeneration.…”
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“…In this review, we first briefly summarize the latest advances in RNA m(6)A biology, and further highlight the roles of m(6)A writers, readers and erasers in normal hematopoiesis and acute myeloid leukemia. …”
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“…The lack of selected professional writers and editors makes the judgement about quality and trustworthiness of the articles a real challenge. …”
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“…However, newer approaches to elderhood have emerged from middle aged writers who imagine an idealized role in later life – the elderhood mystique. …”
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“…The m(6)A modifications of transcripts are coordinately regulated by methyltransferase “writers” and demethylase “erasers”, and produce variable effects via different m(6)A reading protein “readers”. …”
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“…In examining how the concepts of bad faith and inauthenticity are used by Heidegger and Sartre, the article concludes that for both these writers, an authentic subject position can be maintained in later life, without ending up as the otherwise inauthentic subject of others’ collective imaginary of “a good age.”…”
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“…This process is fine-tuned by a myriad of enzymes named “writers, readers and erasers” whose actions are precisely controlled. …”
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“…Modulation of m(6)A relies on m(6)A writers, erasers and readers. m(6)A modification contributes to diverse fundamental biological functions at the molecular, cellular, and physiological levels. …”
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“…Such mechanisms are not only important for physiological functions of normal cells but also prove to be pivotal for the pathogenesis of cancers by driving dysregulated metabolism. M(6)A writers, readers and erasers function co-operatively to promote aberrant glucose, lipid and amino acid metabolism in cancer cells, which in turn support increased proliferative and metastatic potential. …”
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“…Including material from interviews with over two dozen writers, producers, and directors of acclaimed science-themed productions -- as well as scientists, science fiction authors, and science advisor -- Hollyweird Science examines screen science fiction from the sometimes-conflicting vantage points of storytellers, researchers, and viewers. …”
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“…This additional information is from the archives of the Soviet Ministry of Foreign Affairs, the Russian Academy of Sciences, the Soviet Writers' Union et al. in Moscow and St Petersburg. …”
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